Cooperative Breast Cancer Tissue Resource

合作乳腺癌组织资源

• 批准号: 6933874
• 负责人: ANDREW George GLASS
• 金额: $ 30.14万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6933874
• 关键词: archives; automated medical record system; breast neoplasms; cancer registry /resource; clinical research; cooperative study; data collection; human tissue; microarray technology; sample collection; tissue resource /registry

DESCRIPTION (provided by applicant) The Cooperative Breast Cancer Tissue Resource (CBCTR) is sponsored by the National Cancer Institute to provide archival, paraffin-fixed specimens for the study of molecular markers. Kaiser Permanente, Portland, Oregon (KPNW) has been an active member of this project since 1994 and seeks to continue in this role in the next funding period. The CBCTR has collected over 9000 specimens of breast cancer tissue and linked it to demographic, clinical and outcome variables from cancer registries and medical records. The pathological material can be supplied as sections of blocks from the initial surgery undergone by individual patients or as a Tissue Microarray that combines tissue cores from hundreds of specimens. Researchers may apply for this material to enable the testing and/or validation of candidate prognostic markers. An independent Research Evaluation Panel evaluates these requests for scientific merit and technical feasibility. The Coordinating Committee of the CBCTR, comprising the Principal Investigators of the four sites, reviews these requests for appropriateness for the Resource. Considerations include the likelihood of success, impact on workloads and effect on the continuing operation and usability of the Resource. KPNW has contributed over 2400 specimens and distributed hundreds of tissue samples in the process of filling requests from researchers in the community. In addition, KPNW investigators and staff have contributed to the development and modifications of the procedures used in daily operations, to papers and presentations about the CBCTR, to displays at scientific meetings and to publicity efforts in the scientific community. As the CBCTR approaches its goal of wider use of its specimens, particularly of the TMAs, KPNW stands ready to replenish the collection with more, previously unexamined specimens from our files.

描述(由申请人提供) 合作乳腺癌组织资源(CBCTR)由国家癌症研究所赞助，为分子标记的研究提供石蜡固定的存档标本。俄勒冈州波特兰的Kaiser Permanente(KPNW)自1994年以来一直是该项目的积极成员，并寻求在下一个资助期继续发挥这一作用。 CBCTR已经收集了9000多个乳腺癌组织样本，并将其与癌症登记和医疗记录中的人口统计、临床和结果变量联系起来。病理材料可以作为个别患者进行的初始手术的切片提供，也可以作为结合数百个样本组织核心的组织微阵列提供。研究人员可以申请这一材料，以便能够测试和/或验证候选预后标志物。一个独立的研究评估小组评估这些请求的科学价值和技术可行性。由四个地点的首席调查员组成的CBCTR协调委员会审查这些资源适当性的请求。 考虑因素包括成功的可能性、对工作负载的影响以及对资源的持续运营和可用性的影响。在满足社区研究人员的请求的过程中，KPNW捐赠了2400多个标本，分发了数百个组织样本。此外，KPNW的调查人员和工作人员对日常业务中使用的程序的发展和修改、关于CBCTR的论文和介绍、在科学会议上的展示以及科学界的宣传努力作出了贡献。随着CBCTR接近其更广泛地使用其标本的目标，特别是TMA，KPNW随时准备用我们档案中更多以前未经检查的标本来补充收藏。