Cooperative Breast Cancer Tissue Resource

合作乳腺癌组织资源

• 批准号: 7625370
• 负责人: ANDREW George GLASS
• 金额: $ 7.05万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7625370
• 关键词: Biological Markers; Biomedical Research; Client; Clinical; Clinical Markers; Collection; Communities; Cooperative Breast Cancer Tissue Resource; Daily; Data; Data Sources; Development; Diagnosis; Diagnostic tests; Evaluation; Evaluation Research; Funding; Glass; Goals; Individual; Institution; Letters; Link; Malignant Neoplasms; Medical Records; Modification; National Cancer Institute; Operative Surgical Procedures; Oregon; Outcome; Paper; Paraffin; Pathologic; Patients; Principal Investigator; Procedures; Process; Prognostic Marker; Request for Applications; Research Personnel; Resources; Role; Site; Slide; Source; Specimen; Testing; Tissue Microarray; Tissue Sample; Tissues; U-Series Cooperative Agreements; United States; Update; Validation; Woman; Work; Workload; base; cancer diagnosis; design; malignant breast neoplasm; member; neoplasm registry; outcome forecast; programs; research study; response; success; tumor; usability

The Cooperative Breast Cancer Tissue Resource (CBCTR) is sponsored by the National Cancer Institute to provide acrchival, paraffin-fixed specimens for the study of molecular markers. Kaiser Permanente, Portland, Oregon (KPNW) has been an active member of this project since 1994 and seeks to continue in this role in the next funding period. The CBCTR has collected over 9000 specimens of breast cancer tissue and linked it to demographic, clinical and outcome variables from cancer registries and medical records. The pathological material can be supplied as sections of blocks from the initial surgery undergone by individual patients or as a Tissue Microarray that combines tissue cores from hundreds of specimens. Researchers may apply for this material to enable the testing and/or validation of candidate prognostic markers. An independent Research Evaluation Panel evaluates these requests for scientific merit and technical feasibility. The Coordinating Committee of the CBCTR, comprising the Principal Investigators of the four sites, reviews these requests for appropriateness for the Resource. Considerations include the likelihood of success, impact on workloads and effect on the continuing operation and usability of the Resource. KPNW has contributed over 2400 specimens and distributed hundreds of tissue samples in the process of filling requests from researchers in the community. In addition, KPNW investigators and staff have contributed to the development and modifications of the procedures used in daily operations, to papers and presentations about the CBCTR, to displays at scientific meetings and to publicity efforts in the scientific community. As the CBCTR approaches its goal of wider use of its specimens, particularly of the TMAs, KPNW stands ready to replenish the collection with more, previously unexamined specimens from our files.

合作乳腺癌组织资源（CBCTR）由国家癌症研究所赞助， 为分子标记物的研究提供石蜡固定的标本。凯撒医疗机构， 俄勒冈州波特兰（KPNW）自1994年以来一直是该项目的积极成员，并寻求继续在 在下一个融资周期中发挥这一作用。 CBCTR已经收集了9000多个乳腺癌组织样本，并将其与人口统计学， 来自癌症登记和医疗记录的临床和结果变量。病理材料可以是 作为个体患者初次手术的组织块切片或作为组织提供 微阵列结合了数百个标本的组织核心。研究人员可以申请这种材料 以使得能够测试和/或验证候选预后标志物。一个独立的研究 评估小组评估这些申请的科学价值和技术可行性。协调 CBCTR委员会由四个研究中心的主要研究者组成，负责审查这些请求 资源的适当性。考虑因素包括成功的可能性、对工作负载的影响 以及对资源的持续运作和可用性的影响。 KPNW在研究过程中贡献了2400多个标本，并分发了数百个组织样本。 满足社区研究人员的要求。此外，KPNW调查人员和工作人员还 协助制定和修改日常业务中使用的程序， 关于CBCTR的介绍，在科学会议上的展示以及在科学领域的宣传工作 社区随着CBCTR接近其更广泛使用其标本的目标，特别是TMA， KPNW随时准备从我们的档案中补充更多以前未经检查的标本。

项目成果

Long-term outcomes after radical prostatectomy performed in a community-based health maintenance organization.

在社区健康维护组织中进行根治性前列腺切除术后的长期结果。

• DOI: 10.1002/cncr.11886
• 发表时间: 2004
• 期刊: Cancer.
• 作者: Zhang,Ying;Glass,Andrew;Bennett,Nicole;Oyama,KarenA;Gehan,Edmund;Gelmann,EdwardP
• 通讯作者: Gelmann,EdwardP