COOPERATIVE BREAST CANCER TISSUE RESOURCE (CBCTR)

合作乳腺癌组织资源 (CBCTR)

• 批准号: 6533151
• 负责人: ANDREW George GLASS
• 金额: $ 19.16万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6533151
• 关键词: breast neoplasms; cancer information system; cancer registry /resource; clinical research; cooperative study; human subject; tissue resource /registry

DESCRIPTION: (Applicant's Description) The Cooperative Breast Cancer Tissue Resource (CBCTR) represents a collaboration between four institutions that possess archives with large numbers of formalin-fixed breast cancer specimens. These four sites, under Cooperative Agreements with the NCI, have created the CBCTR as a tissue resource for investigators of breast cancer. The CBCTR was originally conceived to provide large numbers of specimens particularly for definitive studies of prognostic markers. The CBCTR has enrolled nearly 9,000 archival breast cancer specimens together with clinical and follow-up information about each case. The material exists as a "virtual bank" with the actual specimens remaining at the individual sites but a Central Database tracking each specimen. The database is mounted on the World Wide Web and may be searched by investigators seeking to ascertain the number and type of material available from this resource. Investigators may then apply to the CBCTR for tissue specimens. Applications are reviewed by a panel of experts, the Research Evaluation Panel, for scientific merit and by the CBCTR Coordinating Committee of Principal Investigator's for feasibility, prior to providing the requested specimens. Kaiser Permanente, Northwest Division has provided over 2,500 specimens to the CBCTR and is reapplying for funding to continue its efforts in this project. This highly integrated and stable medical care system represents an ideal setting for such a project. It has diagnosed a large number of breast cancers since 1970, has archived all such specimens and has complete clinical and follow-up information in its files on all patients. Finally, this organization is committed to research in the public domain and seeks to share its resources with others in the pursuit of breast cancer research.

描述：（申请人的描述） 合作乳腺癌组织资源（CBCTR）代表了一个 拥有大量档案的四个机构之间的合作 福尔马林固定的乳腺癌标本的数量。 这四个网站，根据 与NCI的合作协议，创建了CBCTR作为组织 乳腺癌的治疗方法 CBCTR最初是 设想提供大量的标本，特别是为确定 预后标志物的研究。 CBCTR已经登记了近9,000份档案 乳腺癌标本以及临床和随访信息 关于每一个案子。 材料作为“虚拟银行”存在， 样本保留在各个研究中心，但中央数据库跟踪 每个样本 数据库安装在万维网上， 调查人员搜查，以确定数量和类型， 材料可从这个资源。 然后，调查人员可以向 组织标本的CBCTR。 申请由一个小组审查， 专家，研究评估小组，为科学价值和由 CBCTR主要研究者可行性协调委员会， 在提供所要求的样本之前。 Kaiser Permanente，西北分部提供了2,500多个标本， CBCTR，并正在重新申请资金，以继续在这方面的努力 项目 这种高度整合和稳定的医疗体系代表了 是这样一个项目的理想场所。 它已经诊断出大量的 乳腺癌，自1970年以来，已存档所有此类标本，并已完成 所有患者的临床和随访信息。 最后， 该组织致力于公共领域的研究，并寻求 在乳腺癌研究中与其他人分享资源。