PROSPECTIVE EVALUATION OF IMPLANT SUPPORTED BRIDGES

种植体支撑桥的前瞻性评估

• 批准号: 2897006
• 负责人: MICHAEL Steven BLOCK
• 金额: $ 10.6万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-01 至 2001-05-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2897006
• 关键词: biomaterial evaluation; clinical research; dental disorder diagnosis; dental plaque; dental radiography; endosseous dental implant; gingiva; human subject; human therapy evaluation; longitudinal human study; mandible /maxilla; medical implant science; medical rehabilitation related tag; oral pharyngeal surgery; physiologic bone resorption; tooth

DESCRIPTION: This application proposes continuing a study for years 6-10. The investigators are studying the effect of rigid and non-rigid attachment of natural teeth to osseointegrated implants. The previous applications recommended recruiting fifty patients who were missing all the maxillary teeth and mandibular right and left second premolars and molars for the study. Each patient received a one two-staged hydroxyapatite-coated implant on each side of the mandible in the first molar area. A bridge was attached to the first mandibular premolar and the hydroxyapatite implant. On one side, the bridge was attached to the premolar and implant using a rigid technique while on the opposite side, the bridge was attached using a non-rigid, semi- precision slot attachment. A maxillary denture opposed the bridges. The patients are examined every 6 months. Standardized radiographs, soft tissue exams, and satisfaction evaluations are performed every six months. The investigators had planned to recruit 20 patients in each of the first 2 years and 10 patients in the third year. However, their recruitment process has taken longer than planned. A total of 42 patients was recruited during the first 4 years of the study. Most of the patients were recruited and restored in years 3 and 4 rather than in years 1 and 2. The investigators have not changed the study protocol from the previously approved grant. They are requesting funding to support 5 more years of follow-up on the 42 patients. They do not plan to recruit any new patients. The effects of the bridge attachment between osseointegrated implants and natural teeth will be evaluated using measurements of gingival bleeding, plaque and calculus indices, presence of attached gingiva, vertical bone loss using standard radiographs, and tooth and implant mobility.

描述：本申请建议继续研究多年 6-10.研究人员正在研究刚性和非刚性 天然牙齿与骨整合种植体的附着。前一 申请人建议招募50名患者， 上颌牙齿和下颌右、左第二前磨牙， 臼齿的研究。每个病人都接受了一个两阶段的 下颌骨两侧的羟基磷灰石涂层植入物， 第一磨牙区第一个下颌骨上连接了一座桥 前磨牙和羟基磷灰石植入物。在桥的一边， 附着在前磨牙和种植体上， 另一边，桥连接使用非刚性，半， 精确的插槽连接。上颌义齿对着牙桥。 患者每6个月检查一次。标准化的X光片， 每六个月进行一次软组织检查和满意度评估 个月 研究人员计划在每个研究中招募20名患者， 前2年和第3年的10名患者。但他们的 招聘过程比计划的要长。共有42 在研究的前4年期间招募患者。大部分 这些患者在第3年和第4年被招募并恢复，而不是 在第一年和第二年。研究人员没有改变研究 从以前批准的协议。他们要求 资金支持对42名患者进行5年以上的随访。他们 不打算招募新的患者。 骨结合种植体间桥连接的作用 和天然牙齿将使用牙龈测量进行评估， 出血、牙菌斑和牙结石指数、附着牙龈的存在， 使用标准X线片、牙齿和种植体进行垂直骨丢失 迁移率