Paediatric Brain Monitoring with Information Technology (KidsBrainIT): Using Information Technology (IT) Innovations to Improve Childhood brain trauma

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PROJECT AIM: We aim to test two hypotheses: After sustaining traumatic brain injury (TBI), paediatricpatients with a longer period of measured cerebral perfusion pressure (CPP) maintained within thecalculated optimal CPP (CPPopt) ranges have (1) an improved outcome, and (2) better toleranceagainst raised intracranial pressure (ICP).WORK PLAN: We set up a new multi-centre, multi-disciplinary and multi-national clinical and researchcollaborative called KidsBrainIT. In a 2-year prospective observational study, 10 centres contributepaediatric TBI patients' annoymised clinical, high-resolution physiological, and outcome data to a centralrepository (KidsBrainIT Data-bank). Using the same methodology as our pilot (optimal CPP calculationand ICP dose-response plots), the main data-set is used to test our hypotheses. A sub-set of data isused to test novel technology and data models. Calculated validated indices is used as metrics ofclinical management quality assurance for feedback to contributing units to improve treatment.EXPLOITATION OF RESULTS: By bringing senior clinicians, engineers, and scientists from differentcentres and countries to the group, KidsBrainIT facilitates testing of clinically relevant therapeuticthresholds and validating new monitoring technologies which are then readily translated back intoclinical practice through contributing units. It will also address inequality and variations in TBImanagement between adult and paediatric practices.