GENETIC STUDIES OF EEG AND ERP TRAITS RELATED TO ALCOHOLISM

与酗酒相关的 EEG 和 ERP 特征的遗传学研究

• 批准号: 6288661
• 负责人: MARY ANNE ENOCH
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6288661
• 关键词: Native Americans; alcoholism /alcohol abuse; anxiety disorders; behavioral /social science research tag; behavioral genetics; brain electrical activity; clinical research; disease /disorder proneness /risk; electroencephalography; evoked potentials; family genetics; genetic markers; genetic polymorphism; human genetic material tag; human population genetics; human subject; interview; linkage mapping; phenotype; psychometrics

Alcoholism is a common heterogenous disease. Heritability has been established in both men and women, but as for other psychiatric diseases, it has proved difficult to map genes directly for reasons such as genetic heterogeneity, phenocopies, penetrance and expressivity, and polygenic effects. We have identified a trait- specific marker for alcoholism vulnerability, the low voltage alpha (LVA) EEG, a normal variant of the resting EEG in which the alpha rhythm is virtually absent. This phenotype is strongly heritable, traitlike, present in 4-11% of the population and accurately determined. We now have a complete data set, including EEG and ERP phenotypes, blind- rated DSM-III-R diagnoses, psychometric tests and DNA on 247 individuals. We have recently replicated the association of LVA with a subtype of alcoholism with anxiety in a comparable sample of 149 unrelated individuals (Enoch et al 1999). LVA was found in 23% of alcoholics, 25% of subjects with an anxiety disorder and 56% of alcoholics with an anxiety disorder compared to 8% of the individuals without alcoholism or an anxiety disorder. In order to obtain sufficient power to map genes for alcoholism, the focus of this study has shifted to a Plains American Indian tribe which has a high prevalence of alcoholism. During the course of this year we performed EEGs and ERPs on 374 tribal members from large pedigrees. We have almost completed the data set of psychiatric diagnoses and DNA from these individuals.We will soon be in a position to start analyses for mapping genes for alcoholism.Formerly titled Genetic studies of the electroencephalogram and event-related potentials. - health & behavior, neurosciences, drinking patterns & causes, electrophysiology/EEG, molecular genetics - Human Subjects: Interview, Questionaires, or Surveys Only

酒精中毒是一种常见的异质疾病。在男性和女性中都建立了遗传力，但对于其他精神病疾病，由于遗传异质性，表皮，渗透率和表现性以及多基因作用，因此很难直接映射基因。我们已经确定了酒精中毒脆弱性的特异性标记，即低压alpha（LVA）脑电图，这是静息脑电图的正常变体，其中alpha节奏实际上不存在。这种表型具有强烈的遗传性，特征般的，是4-11％的人口中，并准确地确定。现在，我们有一个完整的数据集，包括脑电图和ERP表型，盲目的DSM-III-R诊断，心理测试和247个个体的DNA。我们最近在149个无关个体的可比样本中复制了LVA与酒精中毒亚型与焦虑的关联（Enoch等人，1999年）。在23％的酒精中毒中发现了LVA，患有焦虑症的受试者中有25％和56％的焦虑症酗酒者发现了LVA，而没有酒精中毒或焦虑症的人中有8％。为了获得足够的能力来绘制基因的酒精中毒，这项研究的重点已转移到平原的美洲印第安部落，该部落的酗酒率很高。在今年的过程中，我们对来自大型谱系的374名部落成员进行了脑电图和ERP。我们几乎已经完成了这些个体的精神诊断和DNA的数据集。我们很快就可以开始分析用于酒精中毒的基因的分析。脑电图和与事件相关的电位的遗传研究成形为遗传研究。 - 健康与行为，神经科学，饮酒模式和原因，电生理学/脑电图，分子遗传学 - 人类受试者：访谈，问题或调查