CTN: Northern New England Node

CTN：新英格兰北部节点

• 批准号: 7324632
• 负责人: Roger D. Weiss
• 金额: $ 124.68万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7324632
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DESCRIPTION (provided by applicant): This is a proposal for renewal of "Clinical Trials Network (CTN): Harvard University Northern New England Node," submitted in response to RFA-DA-07-001 "Announcement of a Limited Competition of the National Drug Abuse Treatment Clinical Trials Network (U10)." The Northern New England Node (NNEN) brings together research expertise, sophisticated community treatment programs (CTPs), and a wide variety of patients being treated in diverse settings and multiple levels of care. The Node is characterized by a partnership between academic researchers and community-based treatment providers throughout 5 New England states to design and implement addiction treatment studies in community-based treatment programs. The NNEN has demonstrated outstanding progress since entering the CTN in 2002, with a combination of scientific and administrative leadership and excellent trial performance. The NNEN is the Lead Node on a multi-site study of prescription opioid analgesic dependence treatment, and has played a major scientific leadership role in the development and implementation of two CTN studies of patients with substance use disorder and attention deficit hyperactivity disorder. Administrative leadership is exemplified by participation by NNEN members on the 4 key CTN national committees; the NNEN is the only Node to be represented on all of these committees. NNEN members have also been elected to chair several national committees and work groups, demonstrating their excellent reputation among their CTN colleagues. Trial performance has been exemplary: the NNEN has participated in more trials and randomized more participants than any other Node entering in 2002; and has randomized more than twice as many participants in the 2005-2006 Node Trial Performance Report than the average for a CTN Node. Moreover, according to the most recent NIDA Trial Progress Report, the NNEN is the only Node (other than the 2 new Nodes entering the CTN in 2005) to meet or exceed expectations on every performance indicator of every trial the Node has entered. NNEN CTPs have adopted a number of new evidence-based practices, and have themselves disseminated information about these practices regionally, nationally, and internationally. This proposal highlights the accomplishments of the Northern New England Node in the funding period since September 2002. While the Node has made outstanding progress, the proposal also details a number of enhancements to strengthen the NNEN during the renewal period. During the next three years, the NNEN plans to continue to advance the mission of the CTN by implementing and testing state-of-the-art drug abuse treatment interventions, so that clinical programs will use the best treatments available and patients will receive the full benefit of the evolving science of addiction treatment.

描述（由申请人提供）：这是一份更新“临床试验网络（CTN）：哈佛大学新英格兰北部节点”的提案，是为了响应RFA-DA-07-001“国家药物滥用治疗临床试验网络（U10）有限竞争公告”而提交的。北新英格兰节点（NNEN）汇集了研究专业知识，复杂的社区治疗计划（ctp），以及在不同环境和多层次护理中接受治疗的各种患者。Node的特点是新英格兰5个州的学术研究人员和社区治疗提供者之间的合作，在社区治疗项目中设计和实施成瘾治疗研究。NNEN自2002年加入CTN以来，凭借科学和管理的领导以及出色的试验表现，取得了突出的进步。NNEN是处方阿片类镇痛药物依赖治疗的多位点研究的牵头节点，并在物质使用障碍和注意缺陷多动障碍患者的两项CTN研究的开发和实施中发挥了重要的科学领导作用。行政领导体现在NNEN成员参加4个关键的CTN国家委员会；NNEN是唯一一个在所有这些委员会中都有代表的节点。NNEN成员还被选为几个国家委员会和工作组的主席，这表明他们在CTN同事中享有良好的声誉。试验表现堪称典范：NNEN参与的试验和随机分配的参与者比2002年进入的任何其他节点都多；并且在2005-2006年节点试验性能报告中随机分配的参与者人数是CTN节点平均人数的两倍多。此外，根据最新的NIDA试验进度报告，NNEN是唯一一个在每次试验的每个性能指标上都达到或超过预期的节点（除了2005年进入CTN的两个新节点）。NNEN CTPs采用了一些新的基于证据的做法，并在区域、国家和国际上传播了有关这些做法的信息。该提案强调了自2002年9月以来新英格兰北部节点在资助期间所取得的成就。虽然该节点取得了显著进展，但该提案还详细说明了在续期期间加强NNEN的一些改进措施。在接下来的三年里，NNEN计划继续推进CTN的使命，通过实施和测试最先进的药物滥用治疗干预措施，使临床项目将使用最好的治疗方法，使患者能够充分受益于不断发展的成瘾治疗科学。