CTN：新英格兰北部节点-猫眼课题宝

CTN：新英格兰北部节点

批准号：

7324632

负责人：

Roger D. Weiss

金额：

$124.68万

依托单位：

MCLEAN HOSPITAL

依托单位国家：

美国

项目类别：

财政年份：

2002

资助国家：

美国

项目状态：

已结题

起止时间：

2002-09-30 至 2010-08-31

来源：

https://reporter.nih.gov/project-details/7324632

关键词：

AIDS clinical trial group AIDS prevention AIDS/HIV problem Abstinence Abuse Reporting Academic Medical Centers Academic Training Academy Accounting Accreditation Acquired Immunodeficiency Syndrome Acute Address Adherence Administrator Admission activity Adolescence Adolescent Adolescent Development Adolescent Psychiatry Adopted Adoption Adult Adverse effects Adverse event Advisory Committees Advocate Affect African American Age Agreement Alaska Native Alcohol consumption Alcohol dependence Alcohol or Other Drugs use Alcoholism Alcohols All Sites Ambulatory Care Facilities American American Indians American Psychological Association Anti-Retroviral Agents Anxiety Disorders Appendix Applications Grants Applied Research Appointment Archives Area Arizona Armenia Arts Asians Attention Attention deficit hyperactivity disorder Authorship Award Awareness Back Baseline Surveys Beds Behavior Behavior Therapy Behavioral Behavioral Medicine Behavioral Sciences Belief Benefits and Risks Benzodiazepines Binding Sites Biological Biological Assay Biometry Bipolar Disorder Black race Blood Book Chapters Books Boston Brain imaging Budgets Buprenorphine Businesses CAB protocol CD4 Lymphocyte Count Calibration California Cardiovascular system Caring Case Management Case Manager Case Mixes Case Report Form Categories Caucasians Caucasoid Race Censuses Centers for Disease Control and Prevention (U.S.)Certificate of Confidentiality Certification Cervical Chairperson Characteristics Charge Child Child Abuse Child Psychiatry Childhood China Chronic Disease Chronology Cigarette Cigarette Smoker Cities Classification Client Client satisfaction Clinic Clinic Visits Clinical Clinical Practice Guideline Clinical Psychology Clinical Research Clinical Services Clinical Treatment Clinical Trials Clinical Trials Data Monitoring Committees Clinical Trials Design Clinical Trials Network Clinical effectiveness Cocaine Code Cognitive Cognitive Therapy Collaborations Collection Color Combination Drug Therapy Committee Members Communication Communication Research Communities Community Health Centers Community Healthcare Community Surveys Comorbidity Competence Complement Complex Computer software Condition Conduct Clinical Trials Confidentiality Conflict (Psychology)Confusion Consensus Consent Consent Forms Consult Consultations Continuing Education Continuity of Patient Care Contracts Control Groups Counseling Country Couples Therapy Criminal Justice Cues DSM-IV Dace Daily Data Data Aggregation Data Analyses Data Collection Data Quality Data Reporting Databases Day Care Decision Making Delaware Dependence Depressed mood Detection Developed Countries Developing Countries Development Diabetes Mellitus Diagnosis Diagnostic Diffusion Diffusion of Innovation Direct Costs Discipline Disease Distance Education Doctor of Medicine Doctor of Philosophy Documentation Domestic Violence Dose Dropout Drops Drug Addiction Drug Administration Routes Drug Courts Drug Evaluation Drug Metabolic Detoxication Drug abuse Drug resistance Drug usage Drug user Early identification Eating Disorders Economic Conditions Economics Education Educational Activities Educational Assessment Educational Curriculum Educational Intervention Educational process of instructing Educational workshop Effectiveness Effectiveness of Interventions Electronic Mail Electronics Elements Eligibility Determination Employee Employee Strikes End Point Enrollment Ensure Environment Equation Equilibrium Equipment Ethics Ethnic Origin Evaluation Event Evidence based practice Evidence based treatment Exclusion Criteria Exercise Expenditure Face Family Family Physicians Family psychotherapy Fatigue Feasibility Studies Feedback Feeling Fees Fellowship Female Fever Follow-Up Studies Fostering Foundations Frustration Funding Funding Agency Future Gender Gender Issues General Hospitals General Population Genie Geography Gifts Goals Government Agencies Grant Graph Group Therapy Guided imagery Guidelines HIV HIV Infections HIV Seropositivity HIV prevention trials network Halfway Houses Hand Happiness Headache Health Health Alliance Health Insurance Portability and Accountability Act Health Personnel Health Professional Health Services Health Services Accessibility Health Services Research Health Status Health behavior change Healthcare Healthcare Systems Hepatitis C Hepatitis C virus High Risk Woman Highly Active Antiretroviral Therapy Hispanics Home environment Home visitation Homelessness Hospitals Hour House Call Human Resources Human immunodeficiency virus test Hybrids Illicit Drugs Impairment Incentives Independent Scientist Award India Individual Industry Infant Infection Information Systems Informed Consent Injecting drug user Injection of therapeutic agent Inpatients Institute of Medicine (U.S.)Institutes Institution Instruction Insurance Intake Intention Interest Group International International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10)Intervention Intervention Studies Interview Investigation Journals Kenya Knowledge Laboratories Latina Latino Laws Lead Leadership Learning Lebanon Left Legal Length Length of Stay Letters Licensing Life Light Linguistics Link Literature Living Wills Location Logistic Regressions Longevity Mails Maine Maintenance Managed Care Manic Manuals Manuscripts Marijuana Massachusetts Master of Public Health Measurement Measures Mediating Mediator of activation protein Medical Medical center Medicare Medicare/Medicaid Medicine Mental Depression Mental Health Mental Health Services Mental disorders Mentors Meta-Analysis Methadone Methodology Methods Methylphenidate Microprocessor Mid-Career Clinical Scientist Award (K24)Mind Minority Minority Groups Mission Modality Modeling Modification Monitor Mood Disorders Morale Mothers Multi-Institutional Clinical Trial Mutation Myanmar Naloxone Names National Institute of Drug Abuse National Institute of Mental Health National Institute on Alcohol Abuse and Alcoholism National Research Service Awards Nature Nausea Needles Neurology New England New Hampshire Newsletter Newspapers Nicotine Dependence None or Not Applicable Numbers Nurses Nursing Homes Occupations Office of Administrative Management Online Systems Operative Surgical Procedures Opiate Addiction Opioid Opioid Analgesics Organizational Change Organizational Models Other Resources Outcome Outcome Assessment Outcome Measure Outcome Study Outpatients Pacific Island Americans Pain Pain management Paper Participant Patient Education Patient Monitoring Patient Self-Report Patient currently pregnant Patients Pattern Pediatric Hospitals Peer Review Performance Personal Satisfaction Persons Pharmaceutical Preparations Pharmacotherapy Phase Phase III Clinical Trials Phase Transition Physician Executives Physicians Pilot Projects Placebos Plasma Play Pliability Policies Population Population Programs Positioning Attribute Post-Traumatic Stress Disorders Postdoctoral Fellow Postpartum Women Practice Guidelines Pregnant Women Preparation Prevalence Prevention Prevention education Prevention program Principal Investigator Privacy Problem Solving Procedures Process Productivity Professional counselor Program Description Progress Reports Protocols documentation Provider Psyche structure Psychiatrist Psychiatry Psychologist Psychology Psychopharmacology Psychostimulant dependence Psychotherapy Psychotic Disorders Public Health Public Policy Publications Publishing Purpose Qualifying Quality Control Quality of Care Quality of life Questionnaires RNA Race Randomized Randomized Controlled Clinical Trials Randomized Controlled Trials Range Rate Readiness Reading Recommendation Recording of previous events Records Recovery Recruitment Activity Red Cross Registered nurse Regulation Regulatory Affairs Rehabilitation therapy Relapse Relative (related person)Report (document)Reporting Research Research Activity Research Design Research Ethics Research Ethics Committees Research Infrastructure Research Institute Research Methodology Research Personnel Research Project Grants Research Training Residencies Residential Treatment Resistance Resolution Resources Rest Review Committee Review Literature Rhode Island Risk Risk Behaviors Risk Reduction Rivers Role Role playing therapy Route Running Rural Russia Safe Sex Safety Sample Size Sampling Schedule Schizophrenia Science Score Screening procedure Secure Self Efficacy Self Medication Seminal fluid Series Serious Adverse Event Services Severities Sex Behavior Sex Characteristics Sexually Transmitted Diseases Shapes Shipping Ships Side Site Sleep disturbances Smoke Smoker Smoking Social Functioning Social Work Social Workers Societies Solid Solutions Source Specific qualifier value Staff Development Staging Standards of Weights and Measures Statistical Data Interpretation Stratification Stress Structure Subgroup Substance Abuse, Other Substance Addiction Substance Use Disorder Substance abuse problem Sum Summary Reports Supervision Support Groups Support of Research Surveys Survivors Symptoms System Target Populations Techniques Technology Transfer Telephone Testing Textbooks Therapeutic Therapeutic community technique Thinking Time TimeLine Tobacco Toxicology Training Training Activity Training Programs Training and Education Translating Transportation Trauma Travel Treatment Effectiveness Treatment Efficacy Treatment Protocols Treatment Step Treatment outcome Triage Tube USA Georgia Underrepresented Minority United Nations United States National Institutes of Health United States Substance Abuse and Mental Health Services Administration Universities Update Upper arm Urine Validation Vermont Videotape Viral Viral Load result Viral load measurement Virus Virus Diseases Vision Visit Visual Analogue Pain Scale Vulnerable Populations Week Western Asia Georgia Withdrawal Woman Wood material Work World Health Organization Writing Youth acamprosate addiction adolescent smoking aminoglutethimide/danazol/hydrocortisone/tamoxifen antiretroviral therapy authority base behavioral health career chronic pain cigarette smoking clinical research site clinically relevant college comparison group computerized data processing concept contingency management coping cost cost effective cost effectiveness cytarabine/daunorubicin/thioguanine data integrity data management day demographics depressive symptoms design desire disorder later incidence prevention dissemination research document outlines dual diagnosis early /brief intervention /therapy editorial effectiveness clinical trial effectiveness research ethnic minority population expectation experience falls follow-up group counseling health care service utilization health related quality of life hospital bed human subject implementation research implementation trial improved inclusion criteria indexing innovation instrument interest intervention program juvenile delinquent lectures male medical schools medical specialties medication compliance member men motivational enhancement therapy multidisciplinary named group neglect neuropsychological news nicotine abuse nicotine patch novel strategies offender organizational structure outreach parity patient oriented research pediatrician peer performance site pill preference prescription document prescription procedure prevent probation problem solving therapy professor programs prospective protocol development psychoeducation psychologic psychological distress psychopharmacologic psychosocial public policy on tobacco quality assurance racial and ethnic racial difference rehearsal research and development research study research to practice resilience response retinal rods satisfaction self help service utilization severe mental illness sex skills smoking cessation social special interest group statistics study characteristics substance abuser success symposium therapy adherence therapy design therapy development tool topiramate training project transitional housing transmission process treatment center treatment duration treatment effect treatment program treatment site treatment trial trial comparing volunteer willingness young adult

项目摘要

项目成果

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中文摘要

翻译

描述（由申请人提供）：这是一份更新“临床试验网络（CTN）：哈佛大学新英格兰北部节点”的提案，是为了响应RFA-DA-07-001“国家药物滥用治疗临床试验网络（U10）有限竞争公告”而提交的。北新英格兰节点（NNEN）汇集了研究专业知识，复杂的社区治疗计划（ctp），以及在不同环境和多层次护理中接受治疗的各种患者。Node的特点是新英格兰5个州的学术研究人员和社区治疗提供者之间的合作，在社区治疗项目中设计和实施成瘾治疗研究。NNEN自2002年加入CTN以来，凭借科学和管理的领导以及出色的试验表现，取得了突出的进步。NNEN是处方阿片类镇痛药物依赖治疗的多位点研究的牵头节点，并在物质使用障碍和注意缺陷多动障碍患者的两项CTN研究的开发和实施中发挥了重要的科学领导作用。行政领导体现在NNEN成员参加4个关键的CTN国家委员会；NNEN是唯一一个在所有这些委员会中都有代表的节点。NNEN成员还被选为几个国家委员会和工作组的主席，这表明他们在CTN同事中享有良好的声誉。试验表现堪称典范：NNEN参与的试验和随机分配的参与者比2002年进入的任何其他节点都多；并且在2005-2006年节点试验性能报告中随机分配的参与者人数是CTN节点平均人数的两倍多。此外，根据最新的NIDA试验进度报告，NNEN是唯一一个在每次试验的每个性能指标上都达到或超过预期的节点（除了2005年进入CTN的两个新节点）。NNEN CTPs采用了一些新的基于证据的做法，并在区域、国家和国际上传播了有关这些做法的信息。该提案强调了自2002年9月以来新英格兰北部节点在资助期间所取得的成就。虽然该节点取得了显著进展，但该提案还详细说明了在续期期间加强NNEN的一些改进措施。在接下来的三年里，NNEN计划继续推进CTN的使命，通过实施和测试最先进的药物滥用治疗干预措施，使临床项目将使用最好的治疗方法，使患者能够充分受益于不断发展的成瘾治疗科学。

英文摘要

DESCRIPTION (provided by applicant): This is a proposal for renewal of "Clinical Trials Network (CTN): Harvard University Northern New England Node," submitted in response to RFA-DA-07-001 "Announcement of a Limited Competition of the National Drug Abuse Treatment Clinical Trials Network (U10)." The Northern New England Node (NNEN) brings together research expertise, sophisticated community treatment programs (CTPs), and a wide variety of patients being treated in diverse settings and multiple levels of care. The Node is characterized by a partnership between academic researchers and community-based treatment providers throughout 5 New England states to design and implement addiction treatment studies in community-based treatment programs. The NNEN has demonstrated outstanding progress since entering the CTN in 2002, with a combination of scientific and administrative leadership and excellent trial performance. The NNEN is the Lead Node on a multi-site study of prescription opioid analgesic dependence treatment, and has played a major scientific leadership role in the development and implementation of two CTN studies of patients with substance use disorder and attention deficit hyperactivity disorder. Administrative leadership is exemplified by participation by NNEN members on the 4 key CTN national committees; the NNEN is the only Node to be represented on all of these committees. NNEN members have also been elected to chair several national committees and work groups, demonstrating their excellent reputation among their CTN colleagues. Trial performance has been exemplary: the NNEN has participated in more trials and randomized more participants than any other Node entering in 2002; and has randomized more than twice as many participants in the 2005-2006 Node Trial Performance Report than the average for a CTN Node. Moreover, according to the most recent NIDA Trial Progress Report, the NNEN is the only Node (other than the 2 new Nodes entering the CTN in 2005) to meet or exceed expectations on every performance indicator of every trial the Node has entered. NNEN CTPs have adopted a number of new evidence-based practices, and have themselves disseminated information about these practices regionally, nationally, and internationally. This proposal highlights the accomplishments of the Northern New England Node in the funding period since September 2002. While the Node has made outstanding progress, the proposal also details a number of enhancements to strengthen the NNEN during the renewal period. During the next three years, the NNEN plans to continue to advance the mission of the CTN by implementing and testing state-of-the-art drug abuse treatment interventions, so that clinical programs will use the best treatments available and patients will receive the full benefit of the evolving science of addiction treatment.

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