CTN: Northern New England Node

CTN：新英格兰北部节点

• 批准号: 7498062
• 负责人: Roger D. Weiss
• 金额: $ 40万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498062
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This is a proposal for renewal of "Clinical Trials Network (CTN): Harvard University Northern New England Node," submitted in response to RFA-DA-07-001 "Announcement of a Limited Competition of the National Drug Abuse Treatment Clinical Trials Network (U10)." The Northern New England Node (NNEN) brings together research expertise, sophisticated community treatment programs (CTPs), and a wide variety of patients being treated in diverse settings and multiple levels of care. The Node is characterized by a partnership between academic researchers and community-based treatment providers throughout 5 New England states to design and implement addiction treatment studies in community-based treatment programs. The NNEN has demonstrated outstanding progress since entering the CTN in 2002, with a combination of scientific and administrative leadership and excellent trial performance. The NNEN is the Lead Node on a multi-site study of prescription opioid analgesic dependence treatment, and has played a major scientific leadership role in the development and implementation of two CTN studies of patients with substance use disorder and attention deficit hyperactivity disorder. Administrative leadership is exemplified by participation by NNEN members on the 4 key CTN national committees; the NNEN is the only Node to be represented on all of these committees. NNEN members have also been elected to chair several national committees and work groups, demonstrating their excellent reputation among their CTN colleagues. Trial performance has been exemplary: the NNEN has participated in more trials and randomized more participants than any other Node entering in 2002; and has randomized more than twice as many participants in the 2005-2006 Node Trial Performance Report than the average for a CTN Node. Moreover, according to the most recent NIDA Trial Progress Report, the NNEN is the only Node (other than the 2 new Nodes entering the CTN in 2005) to meet or exceed expectations on every performance indicator of every trial the Node has entered. NNEN CTPs have adopted a number of new evidence-based practices, and have themselves disseminated information about these practices regionally, nationally, and internationally. This proposal highlights the accomplishments of the Northern New England Node in the funding period since September 2002. While the Node has made outstanding progress, the proposal also details a number of enhancements to strengthen the NNEN during the renewal period. During the next three years, the NNEN plans to continue to advance the mission of the CTN by implementing and testing state-of-the-art drug abuse treatment interventions, so that clinical programs will use the best treatments available and patients will receive the full benefit of the evolving science of addiction treatment.

这是一份更新“临床试验网络（CTN）：哈佛大学北方新 英格兰节点，”提交以回应RFA-DA-07-001“有限竞争的公告， 国家药物滥用治疗临床试验网络（U10）。“北方新英格兰节点（NNEN） 汇集了研究专业知识，复杂的社区治疗计划（CTP），以及各种各样的 患者在不同的环境和多层次的护理中接受治疗。节点的特征在于 学术研究人员和社区治疗提供者之间的合作伙伴关系贯穿5个新 英格兰各州将在社区治疗中设计和实施成瘾治疗研究 程序. 自2002年加入CTN以来，NNEN取得了显著进展， 科学的行政领导能力和出色的审判业绩。NNEN是一个 多地点研究阿片类药物依赖的处方镇痛治疗，并发挥了重大的科学 在药物使用患者的两项CTN研究的开发和实施中发挥领导作用 注意缺陷多动障碍和注意缺陷多动障碍。行政领导体现在参与 由NNEN成员在4个关键的CTN国家委员会; NNEN是唯一的节点， 所有这些委员会。NNEN成员还当选为几个国家委员会的主席， 工作组，展示了他们在CTN同事中的良好声誉。试验性能具有 作为典范：NNEN参与了更多的试验，随机分配了更多的参与者，比其他任何组织都多。 Node于2002年进入;并在2005-2006年Node中随机分配了两倍多的参与者 试验性能报告高于CTN节点的平均值。此外，根据最新的NIDA 试验进度报告，NNEN是唯一的节点（除了2005年进入CTN的2个新节点）， 达到或超过节点已进入的每个试验的每个性能指标的预期。NNEN 现金转拨方案采用了一些新的循证做法，并自行传播 在区域、国家和国际上提供有关这些做法的信息。 本建议书强调了北方新英格兰节点在资助期内取得的成就 自2002年9月以来。虽然节点已经取得了突出的进展，但该提案还详细说明了一些 在续期期间，我们会加强该网络的功能。在接下来的三年里， 计划通过实施和测试最先进的药物滥用，继续推进CTN的使命 治疗干预，使临床项目将使用最好的治疗方法，患者将 接受不断发展的成瘾治疗科学的全部好处。