International Veterinary Vaccinology Network
国际兽医疫苗学网络
基本信息
- 批准号:MR/R005958/1
- 负责人:
- 金额:$ 306.7万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2017
- 资助国家:英国
- 起止时间:2017 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In many 'low-middle-income-countries' (LMICs) the livestock sector (including poultry and aquaculture) accounts for up to 80% of agricultural GDP, with a majority of the rural poor raising livestock as a means of securing or diversifying income. Improving livestock productivity through the development and deployment of effective veterinary vaccines is thus critical not only to secure food supply and contain the many zoonotic (i.e. transmissible from animal to human) diseases that are prevalent in LMICs, but also to secure income and thus offer a pathway for alleviating poverty.Despite several successful multi-national collaborations addressing livestock health in LMICs there is still not a 'universal' Network that can be readily accessed by all researchers working on veterinary vaccine development for LMIC-application. There is also a continuing unmet demand for increased knowledge and technology transfer between researchers in the UK and LMICs and also between researchers in the human and veterinary vaccinology communities. Here we propose the formation of an International Veterinary Vaccinology Network (IVVN) that provides a forum for the integration of inputs from biological scientists, other specialists (e.g. economists), industry, policymakers and regulatory bodies to focus specifically on development of vaccines for priority livestock diseases of LMICs. By establishing an integrated community and facilitating the formation of strategically devised collaborations between scientists with complementary expertise, the IVVN will enable new approaches to tackling the many scientific 'bottle-necks' that frustrate vaccine development to be adopted. As many of the scientific obstacles that impede development of vaccines are common to both human and veterinary vaccinology, the research conducted by IVVN members will frequently have implications for human vaccine development and so fulfil a 'one-health' remit.The IVVN will actively seek to engage scientists and industrial partners (including those who may not usually consider applying their skills to LMIC or veterinary problems) from the breadth of disciplines that can be applied to vaccine development. The IVVN will provide opportunities for new inter-disciplinary partnerships that tackle specific scientific challenges to be formed (member-led annual scientific meetings and workshops) and then support these partnerships by funding preliminary experiments to generate novel scientific findings (pump-priming funding and laboratory exchanges) that will contribute to the development of new vaccines. The IVVN will identify opportunities across the whole spectrum of veterinary vaccinology where application of new scientific approaches can effectively address long-standing obstacles to vaccine design; to keep abreast of these opportunities the IVVN has assembled a management board that has a wide profile of veterinary and human vaccinology expertise that will enable rapid integration of new scientific developments and challenges and recruitment of new IVVN members that can bring access to these. This new Network will work alongside the UK Veterinary Vaccinology Network (UK-VVN); overlap of the management groups and membership of the two networks will ensure they function collaboratively and bring mutual benefits. To achieve its aim, it is essential that the IVVN considers vaccinology within the context of the agricultural sectors of LMICs; this knowledge will be provided by LMIC vaccinologists and industrial partners whose representation and leadership will be fundamental to the success of the IVVN.
在许多“中低收入国家”,畜牧业(包括家禽和水产养殖)占农业GDP的80%,大多数农村贫困人口将饲养牲畜作为确保收入或使收入多样化的手段。因此,通过开发和部署有效的兽医疫苗来提高牲畜生产力,不仅对确保粮食供应和遏制许多人畜共患病至关重要,(即从动物传染给人类)疾病,而且还可以确保收入,从而提供减轻贫困的途径。尽管有几个成功的多-在解决低收入国家牲畜健康问题的国家合作方面,仍然没有一个“通用”网络,所有从事低收入国家应用兽医疫苗开发的研究人员都可以随时访问。英国和中低收入国家的研究人员之间以及人类和兽医疫苗学领域的研究人员之间的知识和技术转让需求也一直未得到满足。在此,我们建议成立国际兽医疫苗学网络(IVVN),为整合生物科学家、其他专家(如经济学家)、行业、政策制定者和监管机构的投入提供一个论坛,专门侧重于开发针对中低收入国家重点牲畜疾病的疫苗。通过建立一个综合社区,并促进具有互补专业知识的科学家之间形成战略性合作,IVVN将能够采用新的方法来解决阻碍疫苗开发的许多科学“瓶颈”。由于许多阻碍疫苗开发的科学障碍是人类和兽医疫苗学共同的,IVVN成员所进行的研究将经常对人类疫苗的开发产生影响,从而实现“一种健康”的使命。IVVN将积极寻求科学家和工业合作伙伴的参与(包括那些通常不考虑将其技能应用于LMIC或兽医问题的人)从可应用于疫苗开发的学科的广度中获益。IVVN将为新的跨学科伙伴关系提供机会,以应对将要形成的具体科学挑战(成员领导的年度科学会议和研讨会),然后通过资助初步实验来支持这些伙伴关系,以产生新的科学发现(泵启动资金和实验室交流),这将有助于新疫苗的开发。IVVN将在兽医疫苗学的整个领域中确定新的科学方法的应用可以有效解决疫苗设计的长期障碍的机会;为了跟上这些机遇,IVVN组建了一个管理委员会,该委员会具有广泛的兽医和人类疫苗学专业知识,这将使新的科学发展和挑战能够快速整合,并招募新的IVVN成员,都能接触到这些这个新的网络将与英国兽医疫苗学网络(UK-VVN)一起工作;两个网络的管理小组和成员的重叠将确保它们协同运作并带来互利。为了实现其目标,IVVN必须在LMIC农业部门的背景下考虑疫苗学; LMIC疫苗学家和工业合作伙伴将提供这些知识,他们的代表和领导将是IVVN成功的基础。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Stability of Chimpanzee Adenovirus Vectored Vaccines (ChAdOx1 and ChAdOx2) in Liquid and Lyophilised Formulations.
- DOI:10.3390/vaccines9111249
- 发表时间:2021-10-28
- 期刊:
- 影响因子:7.8
- 作者:Berg A;Wright D;Dulal P;Stedman A;Fedosyuk S;Francis MJ;Charleston B;Warimwe GM;Douglas AD
- 通讯作者:Douglas AD
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Tim Connelley其他文献
Tim Connelley的其他文献
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{{ truncateString('Tim Connelley', 18)}}的其他基金
International Veterinary Vaccinology Network (IVVN)
国际兽医疫苗学网络 (IVVN)
- 批准号:
MR/Y033744/1 - 财政年份:2023
- 资助金额:
$ 306.7万 - 项目类别:
Research Grant
Defining mechani1sms of CD8+ T-cell mediated immunity - using an integrated longitudinal model to achieve an elusive goal.
定义 CD8 T 细胞介导的免疫机制 - 使用集成纵向模型来实现难以捉摸的目标。
- 批准号:
BB/S017151/1 - 财政年份:2020
- 资助金额:
$ 306.7万 - 项目类别:
Research Grant
International Veterinary Vaccinology Network
国际兽医疫苗学网络
- 批准号:
MC_PC_17219 - 财政年份:2018
- 资助金额:
$ 306.7万 - 项目类别:
Intramural
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MR/Y033744/1 - 财政年份:2023
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- 批准号:
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Optimized dosing regimens for the combinations of sulfonamides and trimethoprim in veterinary medicine
兽药中磺胺类药物与甲氧苄啶联合用药的优化给药方案
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