A MULTI-CHANNEL GASTRIC PACER FOR TREATING GASTROPARESIS

用于治疗胃轻瘫的多通道胃起搏器

• 批准号: 6212278
• 负责人: ROBERT Arthur ROSS
• 金额: $ 10万
• 依托单位: VIRGINIA TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2001-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6212278
• 关键词: biomedical equipment development; electrical conductance; electrodes; gastrointestinal stimulator; medical implant science; paralysis; stomach; stomach emptying

DESCRIPTION (adapted from the Investigator's Abstract): The project involves the design and construction of a prototype multi-channel phased gastric pacemaker. This device offers a new therapeutic approach for the treatment of gastric motor disorders. Traditionally, the following methods are used to treat patients with gastric motor disorders: 1) medication therapy - The prokinetic agents, metoclopramide, erythromycin, cisapride and domperidone, are used to treat these patients. However, there are a number of patients who are refractory to these therapies. 2) Nutritional support - using total parenteral nutrition or tube feeding via jejunostomy. This only provides nutritional support and does not cure the disease: 3) surgical treatment -as a last resort, antrectomy or total gastrectomy is performed to resolve the problem or relieve gastrointestinal symptoms. Electrical stimulation of the gastrointestinal organs is a promising approach for the treatment of gastric motility disorders. These organs, like the heart, have natural pacemakers and the myoelectrical activity they generate can be entrained by electrical pacing. The successful entrainment of the gastric slow wave is believed to be essential in normalizing gastric myoelectrical dysrhythmias. Although most research in gastrointestinal pacing has involved single point stimulation, recent studies have shown that multi-channel stimulation provides better performance in terms of gastric slow wave entrainment and energy consumption. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自研究者摘要）：该项目涉及 多通道相控胃的设计与制作 起搏器该装置为治疗 胃运动障碍传统上，以下方法用于治疗 胃动力障碍患者：1）药物治疗-促动力 药物甲氧氯普胺、红霉素、西沙必利和多潘立酮用于 治疗这些病人。然而，有一些患者 对这些疗法无效。2)营养支持-使用全胃肠外 营养或通过空肠造口术管饲。它只提供营养 支持和不治愈疾病：3）手术治疗-作为最后的手段， 进行胃窦切除术或全胃切除术以解决问题或缓解 胃肠道症状胃肠电刺激 器官是治疗胃动力障碍的有前途的方法。 这些器官，如心脏，有天然的起搏器和肌电 它们产生的活动可以通过电起搏进行。成功 胃慢波的夹带被认为是正常化 胃肌电节律紊乱虽然大多数胃肠研究 起搏涉及单点刺激，最近的研究表明， 多通道刺激在胃减慢方面提供更好的性能 波浪卷吸和能量消耗。 拟议商业应用：不可用