Statistical methods and applications in growth and development - SITAR, LMS and IOTF

生长发育中的统计方法和应用 - SITAR、LMS 和 IOTF

• 批准号: MR/R010692/1
• 负责人: Timothy Cole
• 金额: $ 12.29万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FR010692%2F1
• 关键词: Statistical; methods; applications; growth; development

The study of human growth and development involves the assessment and summary of size and how it changes over time. Assessment can take place on several different timescales: e.g. one-off, i.e. a single measurement to assess size using a growth reference; and longer term, where several measurements over an extended period of time define the shape of the individual's growth curve. Both timescales involve statistical issues that the author has previously studied: his LMS method (1992) for constructing growth references, and his SITAR mixed effects growth model for analysing growth curves (2010). The aim of the grant is to progress both topics: providing web-based software to replace the author's popular but now ageing Excel add-in LMSgrowth and PC program LMSchartmaker for manipulating growth data; and continuing to develop his SITAR model, as funded with a current MRC grant, by extending the existing dedicated R library and highlighting further novel applications of the method.

对人类生长发育的研究涉及对大小的评估和总结，以及它如何随时间变化。评估可以在几个不同的时间尺度上进行：例如一次性的，即使用生长参考评估大小的单次测量;以及长期的，其中在延长的时间段内的几次测量定义了个体生长曲线的形状。这两个时间尺度都涉及作者以前研究过的统计问题：他的LMS方法（1992）用于构建增长参考，他的SITAR混合效应增长模型用于分析增长曲线（2010）。该补助金的目的是两个主题的进展：提供基于网络的软件，以取代作者的流行，但现在老化的Excel插件LMSgrowth和PC程序LMSchartmaker操纵增长数据;并继续发展他的SITAR模型，与目前的MRC补助金资助，通过扩展现有的专用R库，并强调进一步的新应用的方法。

项目成果

Relating weight growth trajectory to height and age.

将体重增长轨迹与身高和年龄联系起来。

• DOI: 10.1002/sim.8109
• 发表时间: 2019
• 期刊: Statistics in medicine
• 影响因子: 2
• 作者: Cole TJ

Optimal design for longitudinal studies to estimate pubertal height growth in individuals.

• DOI: 10.1080/03014460.2018.1453948
• 发表时间: 2018-06
• 期刊: Annals of human biology
• 影响因子: 1.7
• 作者: Cole TJ