NONINVASIVE MYOCARDIAL MOTION ANALYSIS WITH MRI

描述：这是一项关于继续开展以下工作的建议： 相位对比磁共振心肌运动分析 (MRI)朝着改进的、非侵入性评估的最终目标， 心肌缺血和其他心脏病患者的管理 病理学 我们已经成功开发出一种技术 使用以下方法获得的速度图中有关心肌动力学的信息 MRI提供了许多显著的优势，超过目前其他 可用的非侵入性方法，如超声和核医学。 不透射线标记物的视频荧光成像和声显微测量，金 由于它们的准确性， 他们研究单个心肌样本收缩的能力， 对今天所知的心肌动力学有很大的影响。 然而，这些技术是高度侵入性的，只能用于 调查或 另一种MRI方法，心肌标记，与 我们的技术能够测量单个区域的运动， 已经提供了关于心肌生理学的基本信息。 我们的相位对比技术具有许多额外的优点，因为它具有 能够容易地研究整个心动周期， 回顾性分析，并绘制三维应变参数 通过前所未有的空间采样。 拟议的工作是我们成就的直接延伸，并形成了一个 一个有凝聚力的计划，我们将：（1）开发多炮脉冲序列 不受运动和其他数据源产生的伪影的影响 不一致，这将产生与 在体外表现出优异的性能，（2）开发和测试 从速度中提取和显示运动信息的先进方法 （3）在一组心脏移植中进行体内验证 先前植入不透射线标记的患者，以及（4）测试 方法在心肌缺血的动物模型（顿抑心肌和 急性心肌梗塞）。 这些实验将证明我们的 能够量化模型中的区域和全局应变参数 缺血性心脏病 最终，监测收缩功能的能力，结合 对灌注敏感的测量，应该允许患者 根据治疗的风险和潜在获益分层 干预措施。 随着这项工作的顺利完成，我们将 验证了该技术用于无创评估的准确性， 心肌动力学，并将有一个独特的工具，可以传播 用于临床和研究MRI中的心脏生理学研究 世界各地的设置。

DESCRIPTION: This is a proposal for the continuation of our work on myocardial motion analysis with phase contrast Magnetic Resonance Imaging (MRI) toward the ultimate goal of improved, noninvasive evaluation and management of patients with myocardial ischemia and other cardiac pathologies. We have successfully developed a technique that extracts information about myocardial dynamics from velocity maps acquired using MRI which offers many significant advantages over other currently available noninvasive methods such as ultrasound and nuclear medicine. Videofluorography of radiopaque markers and sonomicrometry, the gold standards for determination of cardiac motion due to their accuracy and their ability to study the contraction of individual myocardial samples, are responsible for much of what is known today about myocardial dynamics. However, these techniques are highly invasive and can only be used for research purposes. Another MRI method, myocardial tagging, shares with our technique the ability to measure the motion of individual regions and has already contributed basic information about myocardial physiology. Our phase contrast technique has many additional advantages, since it has the capability to readily study the entire cardiac cycle, to perform retrospective analysis, and to map 3-dimensional strain parameters throughout the heart with unprecedented spatial sampling. The proposed work is a direct extension of our accomplishments and forms a cohesive program in which we will: (1) develop multi-shot pulse sequences that are immune to artifacts from motion and other sources of data inconsistency, and that will yield in vivo performance matching the excellent capabilities demonstrated in vitro, (2) develop and test advanced methods to extract and display motion information from velocity fields, (3) validate the methods in vivo in a group of cardiac transplant patients with previously implanted radiopaque markers, and (4) test the method in animal models of myocardial ischemia (stunned myocardium and acute myocardial infarction). These experiments will demonstrate our ability to quantify both regional and global strain parameters in models of ischemic heart disease. Ultimately, the ability to monitor contractile function, combined with measurements sensitive to perfusion, should allow patients to be stratified according to risk and potential benefit of therapeutic interventions. With the successful completion of this work, we will have validated the accuracy of the technique for the noninvasive evaluation of myocardial dynamics, and will have a unique tool that can be disseminated for the study of cardiac physiology in both clinical and research MRI settings worldwide.