A RESOURCE FOR THE ANALYSIS OF FUNCTIONAL GENOMIC DATA

功能基因组数据分析的资源

• 批准号: 6141724
• 负责人: JAMES I GARRELS
• 金额: $ 43.11万
• 依托单位: PROTEOME, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6141724
• 关键词: Caenorhabditis elegans; computer program /software; computer system design /evaluation; data management; functional /structural genomics; fungal proteins; gene expression; genome; informatics; microarray technology; molecular biology information system; nucleic acid sequence; protein structure function

This proposal describes a resource for Functional Genomics that will serve both industry and academic scientists. The resource will collect public- domain sets of expression data for model organisms generated by DNA microarray analysis, and it will present the data in a uniform format with links to genome an notation databases such as the Yeast Proteome Database (YPD) and the C. elegans Proteome Database (WormPD). The resource will provide software tools for automatic analysis of expression data using links to annotations and functional classification in Proteome Databases. Finally the resource will provide original curation to update on a regular basis the interpretation of each key experiment and to define standard response sets based on the analysis of multiple experiments. The resource will be valuable for academic scientists, and it will allow corporate researchers convenient access to the public data. Finally, the resource will provide a model for annotation and interpretation of functional genomics datasets for human genes. PROPOSED COMMERCIAL APPLICATIONS: DNA microarray technology has become one of the most important genome-based technologies for drug discovery. Companies perform hundreds of global gene expression assays each week, but data interpretation is a serious bottleneck. The proposed product will provide companies with a knowledge-based environment for DNA-microarray analysis. It will link proprietary microarray results with high-quality gene annotation, results from public microarray experiments, and innovative software tools for automatic analysis and annotation of gene expression.

该提案描述了功能基因组学的资源，将为工业和学术科学家提供服务。该资源将收集由DNA微阵列分析产生的模式生物的公共域表达数据集，并将以统一格式提供数据，并链接到基因组和符号数据库，如酵母蛋白质组数据库（YPD）和C。线虫蛋白质组数据库（WormPD）。该资源将提供软件工具，用于使用蛋白质组数据库中的注释和功能分类链接自动分析表达数据。最后，该资源将提供原始策展，以定期更新每个关键实验的解释，并根据多个实验的分析定义标准响应集。该资源对学术科学家来说将是有价值的，它将允许企业研究人员方便地访问公共数据。最后，该资源将为人类基因的功能基因组学数据集的注释和解释提供模型。拟议的商业应用：DNA微阵列技术已成为最重要的基因组为基础的药物发现技术之一。公司每周进行数百次全球基因表达检测，但数据解释是一个严重的瓶颈。拟议的产品将为公司提供一个基于知识的DNA微阵列分析环境。它将把专有的微阵列结果与高质量的基因注释、公共微阵列实验的结果以及用于基因表达自动分析和注释的创新软件工具联系起来。