A CURATED PROTEIN DOMAIN DATABASE FOR GENOME ANNOTATION

用于基因组注释的精选蛋白质域数据库

• 批准号: 6074600
• 负责人: JAMES I GARRELS
• 金额: $ 10万
• 依托单位: PROTEOME, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6074600
• 关键词: Caenorhabditis elegans; Internet; computer program /software; computer system design /evaluation; fungal proteins; genome; informatics; molecular biology information system; protein sequence; protein structure; protein structure function

DESCRIPTION: (Adapted from applicant's abstract): The proposal describes the development of a comprehensively curated database for protein domains to extend the power of the existing protein domain databases for genome annotation. The new Proteome Domain Database (PDD) will complement the other comprehensively curated species-specific databases (YPD and WormPD) developed by Proteome, Inc. Which are already valued resources for annotation of new genome sequences. Like YPD and WormPD, the new Proteome Domain Database will be built Primarily by extensive curation of the research literature to capture Experimental knowledge of properties and functions of the previously Identified protein domains. The PDD will present to users and genome Annotators comprehensive information on the known functions, Regulations, Interactions, and modifications of the protein domains, and through the Existing knowledge will be deeply Integrated with the extensive knowledge already gathered for the Characterized proteins of model organisms. The PDD will be used by Pharmaceutical, biotechnology, genomics companies to add value to their Genomic sequence databases, leading to better understanding of cellular Pathways and selection of drug targets. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：（改编自申请人摘要）：提案描述了 开发一个全面管理的蛋白质结构域数据库， 现有蛋白质结构域数据库在基因组注释中的作用。的 新的蛋白质组结构域数据库（PDD）将全面补充其他 由Proteome，Inc.开发的精选物种特异性数据库（YPD和WormPD）。 它们已经是注释新基因组序列的宝贵资源。 与YPD和WormPD一样，新的蛋白质组结构域数据库将在2017年建立。 通过对研究文献的广泛整理， 先前鉴定的蛋白质的性质和功能的知识 域. PDD将向用户和基因组注释者提供全面的 关于已知功能、法规的信息， 蛋白质结构域的相互作用和修饰，以及通过 现有的知识将与广泛的知识深度融合 已经收集了模式生物的特征蛋白质。所述PDD 将被制药、生物技术、基因组学公司用于增加价值 他们的基因组序列数据库，从而更好地了解 细胞途径和药物靶点的选择。 拟议商业应用：不可用