A CURATED PROTEIN DOMAIN DATABASE FOR GENOME ANNOTATION

描述：(改编自申请人的摘要)：建议书描述了 用于蛋白质结构域扩展的综合数据库的开发 现有蛋白质结构域数据库对基因组注释的能力。这个 新的蛋白质组域数据库(PDD)将与其他数据库全面互补 由Proteome，Inc.开发的特定物种数据库(YPD和WormPD)。 它们已经是注释新基因组序列的有价值的资源。 与YPD和WormPD一样，新的蛋白质组域数据库将主要建立 通过广泛整理研究文献来捕捉实验 了解先前确定的蛋白质的性质和功能 域名。PDD将向用户和基因组注释者呈现全面的 已知的职能、法规、 蛋白质结构域的相互作用和修饰，以及通过 现有的知识将与广博的知识深度结合 已经为模式生物的特征蛋白质收集了。PDD 将被制药、生物技术、基因组学公司用来增加价值 到他们的基因组序列数据库，导致更好地理解 细胞通路与药物靶点的选择。 建议的商业应用：不可用

DESCRIPTION: (Adapted from applicant's abstract): The proposal describes the development of a comprehensively curated database for protein domains to extend the power of the existing protein domain databases for genome annotation. The new Proteome Domain Database (PDD) will complement the other comprehensively curated species-specific databases (YPD and WormPD) developed by Proteome, Inc. Which are already valued resources for annotation of new genome sequences. Like YPD and WormPD, the new Proteome Domain Database will be built Primarily by extensive curation of the research literature to capture Experimental knowledge of properties and functions of the previously Identified protein domains. The PDD will present to users and genome Annotators comprehensive information on the known functions, Regulations, Interactions, and modifications of the protein domains, and through the Existing knowledge will be deeply Integrated with the extensive knowledge already gathered for the Characterized proteins of model organisms. The PDD will be used by Pharmaceutical, biotechnology, genomics companies to add value to their Genomic sequence databases, leading to better understanding of cellular Pathways and selection of drug targets. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE