CEREBRO/OLIVOCEREBELLAR INTERACTIONS IN MOTOR CONTROL

运动控制中的大脑/橄榄小脑相互作用

• 批准号: 6149408
• 负责人: ERIC J LANG
• 金额: $ 5万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6149408
• 关键词: body movement; brain electrical activity; cerebellar Purkinje cell; cerebellum; electrodes; laboratory rat; motor cortex; muscle contraction; neuroanatomy; neuromuscular function; olivary body; optics; vibrissae; videotape /videodisc

DESCRIPTION (from applicant's abstract) The generation of movements is a fundamental function of the nervous system. It is accomplished by a process, termed motor control, involving the interaction of multiple brain regions. The result of this process is motor commands that encode the appropriate muscle combinations and the timing of their activation for carrying out complex movement sequences. The experiments of this proposal will investigate the interaction of two key motor systems (the motor cortex and the olivocerebellar system) in the generation of these motor commands. The ability of the olivocerebellar system to generate rhythmic synchronous discharges suggests that its function is to bind in time the different muscle groups involved in making complex movement sequences. Indeed, damage to the inferior olive produces motor deficits characterized by the loss of precisely timed muscle activation. Thus, to investigate the interaction of the motor cortex and olivocerebellar system in motor control, whisker movements will be evoked by motor cortex stimuli and the influence of olivocerebellar activity on the evoked movements will be determined. The whisker movements will be recorded using either a photodetector device or high speed video taping. Olivocerebellar activity will be monitored with multiple electrode recordings of complex spike (CS) activity from Purkinje cells, the main target of the olivocerebellar system. Multiple electrode recordings allow determination of the spatial patterns of synchronous CS activity. The first goal will be to demonstrate that there is in fact a significant interaction between these two brain systems: that is that synchronous discharges in the olivocerebellar system gate the efficacy of motor cortex activity in producing movement. The next goal will be to investigate whether the rhythmic nature of olivocerebellar activity allows it to function as an internal clock for organizing motor outputs in time. The third goal will be to determine the major brain sites where the interactions between these systems occur. Finally, the question of whether changes in the patterns of synchronous discharge of the olivocerebellar system result in changes in the pattern of coupling of different muscles will be addressed. In sum, these experiments should help to define the role of the olivocerebellar system in motor control as well as the reasons why cerebellar damage results in motor coordination deficits. They thus represent a step toward the more general goal of understanding cerebro-cerebellar interactions in motor control.

描述（来自申请人的摘要）动作的产生是 神经系统的基本功能。 它是由 过程，称为运动控制，涉及多个大脑的相互作用 地区。 此过程的结果是编码的电动机命令 适当的肌肉组合及其激活的时机 进行复杂的运动序列。 该提议的实验 将研究两个关键电机系统的相互作用（运动皮层 以及这些电动机命令的生成中的橄榄脑系统。 橄榄脑系统产生节奏同步的能力 放电表明其功能是在时间上绑定不同的 涉及进行复杂运动序列的肌肉群。 确实，损坏 下橄榄产生的运动不足，其特征是丢失 精确定时肌肉激活。 因此，研究的相互作用 运动控制中的运动皮层和橄榄球系统，晶须 运动皮层刺激将唤起运动和 将确定在诱发运动上的橄榄球活动。 这 晶须运动将使用光电探测器设备或 高速录像带。 橄榄脑活动将通过 Purkinje的复合峰值（CS）活性的多个电极记录 细胞，橄榄球系统的主要目标。 多电极 记录允许确定同步CS的空间模式 活动。 第一个目标是证明实际上有一个 这两个大脑系统之间的显着相互作用：那就是 同步放电在橄榄石系统门中 运动皮层活性在产生运动中。 下一个目标是 研究橄榄脑活动的节奏性是否允许 它可以充当内部时钟，用于及时组织电动机输出。 第三个目标是确定主要的大脑站点 这些系统之间的相互作用发生。 最后，问题是否 橄榄球同步放电模式的变化 系统导致不同肌肉耦合模式的变化 将被解决。 总而言之，这些实验应有助于定义角色 电动机控制中的橄榄球系统以及原因 小脑损伤导致运动协调不足。 他们这样 代表朝着更一般的理解目标迈出的一步 运动控制中的脑脑相互作用。