PATTERN FORMATION IN CHICK MIDBRAIN DEVELOPMENT

PI发现腹侧中脑有一个短暂的组织 形成规则间隔的楔形组织， 组织化学 楔形甚至可以从心室 表面有一系列的脊和槽。 这种模式非常明显 类似于后脑的菱形节，它们承载着许多 解剖学上的标记，使它们长期以来 学期研究。 PI称这些结构为中脑弧。 他 逻辑上假设这些组织区域可能构成 组织神经元及其细胞核的早期模式化机制， 不同的神经元命运以及轴突投射模式， 从弧线中产生并与弧线相连。 他提出了一些 虽然技术上有困难，但很简单的目标， 这些问题。

The PI has found that the ventral midbrain has a transient organization into regularly spaced wedges of tissue distinguished by morphology and histochemistry. The wedges can even be visualized from the ventricular surface as a series of ridges and grooves. The pattern is remarkably similar to the rhombomeres of the hindbrain and they bear a number of anatomical markers that make them essentially as interesting for long term studies. The PI has called these structures midbrain arcs. He hypothesizes logically that these zones of tissue may constitute an early patterning mechanism for organizing neurons and their nuclei with differing neuronal fates as well as the axon projection patterns that arise from and connect with the arcs. He proposes a number of straightforward although technically difficult goals with which to study these various questions.