PATTERN FORMATION IN CHICK MIDBRAIN DEVELOPMENT

PI发现腹侧中脑有一个暂时性的组织 形成按形态区分的规则间隔的组织楔形 组织化学。甚至可以从脑室观察到楔形 表面为一系列的脊状和凹槽。这种模式非常明显 类似于后脑的菱形炸弹，它们带有许多 使它们在很长一段时间内都很有趣的解剖标记 学期学习。PI称这些结构为中脑弧。他 从逻辑上假设这些组织区域可能构成 组织神经元及其核的早期图案化机制 不同的神经元命运以及轴突投射模式 从弧线产生并与弧线连接。他提出了一些建议 学习目标简单明了，虽然在技术上很难实现 这些不同的问题。

The PI has found that the ventral midbrain has a transient organization into regularly spaced wedges of tissue distinguished by morphology and histochemistry. The wedges can even be visualized from the ventricular surface as a series of ridges and grooves. The pattern is remarkably similar to the rhombomeres of the hindbrain and they bear a number of anatomical markers that make them essentially as interesting for long term studies. The PI has called these structures midbrain arcs. He hypothesizes logically that these zones of tissue may constitute an early patterning mechanism for organizing neurons and their nuclei with differing neuronal fates as well as the axon projection patterns that arise from and connect with the arcs. He proposes a number of straightforward although technically difficult goals with which to study these various questions.