PATTERN FORMATION IN CHICK MIDBRAIN DEVELOPMENT

雏鸡中脑发育中的模式形成

• 批准号: 6188081
• 负责人: Clifton W. Ragsdale
• 金额: $ 17.46万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2001-12-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6188081
• 关键词: brain; cell migration; chick embryo; developmental neurobiology; gene expression; histochemistry /cytochemistry; neuroanatomy; nonmammalian vertebrate embryology

The PI has found that the ventral midbrain has a transient organization into regularly spaced wedges of tissue distinguished by morphology and histochemistry. The wedges can even be visualized from the ventricular surface as a series of ridges and grooves. The pattern is remarkably similar to the rhombomeres of the hindbrain and they bear a number of anatomical markers that make them essentially as interesting for long term studies. The PI has called these structures midbrain arcs. He hypothesizes logically that these zones of tissue may constitute an early patterning mechanism for organizing neurons and their nuclei with differing neuronal fates as well as the axon projection patterns that arise from and connect with the arcs. He proposes a number of straightforward although technically difficult goals with which to study these various questions.

PI发现腹侧中脑有一个短暂的组织 分成规则间隔的楔形组织，按形态和特征区分 组织化学。 甚至可以从心室​​看到楔子 表面为一系列的脊和凹槽。 图案非常引人注目 类似于后脑的菱形细胞，它们具有许多 解剖学标记使它们本质上同样有趣 学期研究。 PI 将这些结构称为中脑弧。 他 逻辑上假设这些组织区域可能构成 组织神经元及其细胞核的早期模式机制 不同的神经元命运以及轴突投射模式 由弧产生并与弧相连。 他提出了一些 简单但技术上困难的学习目标 这些各种各样的问题。