COXOFEMORAL JOINT MODIFICATION TO PREVENT HIP DYSPLASIA

髋股关节改造以预防髋关节发育不良

• 批准号: 6171572
• 负责人: MANDI J. LOPEZ
• 金额: $ 4.63万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6171572
• 关键词: computed axial tomography; dogs; enzyme linked immunosorbent assay; heat; hip injury; joint disorder; joint ligament; joint stiffness; nonhuman therapy evaluation; radiography; therapy; veterinary medicine

The goals of this fellowship program are to develop a method for early stabilization of the coxofemoral joint using radio-frequency energy to permit normal development and prevent the clinical manifestations of canine hip dysplasia. The pathology of developmental dysplasia of the hip in children is very similar to the canine version. Ultimately, this research will lead to the establishment of an animal model of radio- frequency treatment of developmental dysplasia of the hip in children. This project will involve the application of radio-frequency energy to the coxofemoral joint capsule of the puppies determined by established radiographic methods to be predisposed to the development of hip dysplasia. Computed tomography will also be used to determine the conformation of the joint. The progression of the disease will then be monitored with radiographs, computed tomography, histology, electron microscopy, joint fluid analysis, and force plate evaluation over a period of two years. Treated animals will be compared to untreated controls. This project will provide an in depth analysis of the progression of canine hip dysplasia in untreated animals and the inhibition of its progression in those treated with radio-frequency.

这个奖学金计划的目标是开发一种早期的方法

项目成果

Acceleration of spinal fusion using syngeneic and allogeneic adult adipose derived stem cells in a rat model.

在大鼠模型中，使用同种异体和同种异体成年脂肪衍生的干细胞加速脊柱融合。

• DOI: 10.1002/jor.20735
• 发表时间: 2009-03
• 期刊: JOURNAL OF ORTHOPAEDIC RESEARCH
• 影响因子: 2.8
• 作者: Lopez, Mandi J.;McIntosh, Kevin R.;Spencer, Nakia D.;Borneman, Jade N.;Horswell, Ronald;Anderson, Paul;Yu, Gang;Gaschen, Lorrie;Gimble, Jeffrey M.
• 通讯作者: Gimble, Jeffrey M.