Prevention of Hip Dysplasia with Thermal Energy

这项研究建议的基本目标是检验以下假设：1)在65摄氏度使用射频能量对有关节松弛证据的幼犬髋股关节囊施加热能将导致正常的髋关节一致性，2)将防止跛行的发展和软骨和骨骼的变化，以及3)不会对关节囊组织的生物力学或粘弹性产生不利影响。这些研究将深入了解肌肉骨骼软组织热改性的基本机制。本研究旨在确定对16周龄关节过度松弛的幼犬进行髋股关节囊热疗是否能预防冠心病。最终，该模型将用于评估热能减少新生儿髋股关节过度松弛的潜力，从而有助于预防DDH。应聘者以优异成绩毕业于洪堡州立大学，获得细胞分子生物学学士学位，辅修化学专业。她在加州千橡市安进大学担任分子生物学家，之后在加州大学戴维斯分校完成医学博士学位。洛佩兹博士在担任D.V.M.学生期间获得了5个奖学金和2个研究助学金。她在堪萨斯州立大学完成了实习，并在威斯康星大学麦迪逊分校获得了大型动物外科住院医师/硕士学位。她是一名委员会认证的大型动物外科医生。洛佩兹博士的硕士论文题为“射频能量对绵羊窒息关节胶囊的影响”，她在比较整形外科研究实验室完成了大部分早期的射频工作。她于1998年被授予NRSA奖，并进行了背景研究和初步研究，这些研究构成了这项提议的基础。她于1999年11月以优异的成绩通过了初试，并计划于2001年6月完成博士学位。她的最终目标是加入一家学术机构的教职，成为一名训练有素的科学家和多产的研究人员，专门从事综合性、翻译性研究。培训环境将指导候选人，同时教授开始独立研究生涯所必需的有价值的研究技术。大部分监督将由马克·D·马克尔提供，他是热组织改良领域的国际知名和受人尊敬的研究员、外科教授和医学科学教授兼主席。咨询委员会将由大学内部备受尊敬和经验丰富的人士组成。比较矫形外科研究实验室是一个成熟的实验室，拥有多学科的研究计划。威斯康星大学为与不同领域的专家互动提供了一个特殊的环境，它以其特殊的研究项目而闻名，特别是在医学科学方面。

The fundamental goals of this research proposal are to test the hypotheses that: 1) application of thermal energy at 65 degrees C using radio-frequency energy to the coxofemoral joint capsule of puppies with radiographic evidence of joint laxity will result in normal hip congruity, 2) will prevent the development of the lameness and the cartilagenous and bony changes characteristic of CHD, and 3) will not have detrimental effects on the biomechanical or viscoelastic properties of the joint capsular tissue. These investigations will yield insights into the fundamental mechanisms of thermal modification of musculoskeletal soft tissue. This research program is designed to determine whether thermal modification of coxocofemoral joint capsule of 16-week-old puppies with excessive joint: laxity will prevent CHD. Ultimately, this model will serve to evaluate the potential of thermal energy to reduce excessively lax coxofemoral joints in neonatal children and thereby help prevent DDH. The candidate of this application graduated magna cum laude from Humboldt State University with a B.S. in cellular-molecular biology and a minor in chemistry. She worked as a molecular biologist at Amgen, Thousand Oaks, CA, before undertaking and; completing her D.V.M. at the University of California-Davis. Dr. Lopez was awarded 5 scholarships and 2 research grants while a D.V.M. student. She completed an internship at Kansas State University and a large animal surgery residency/Master's degree at they University of Wisconsin- Madison. She is a board certified large animal surgeon. Dr. Lopez's Master's thesis was entitled "Effects of Radio-frequency Energy on Ovine Stifle Joint Capsule", and she performed much of the early radio- frequency work in the Comparative Orthopaedic Research Laboratory. She was awarded an NRSA in 1998 and has performed the background research and preliminary, studies that form the basis for this proposal. She passed her preliminary examinations "With Honors" in November, 1999, and is scheduled to complete her PhD in June 2001. Her ultimate goal is to join the faculty of an academic institution as a well-trained scientist and productive researcher specializing in integrative, translational research. The training environment will be guided toward mentoring the candidate while teaching valuable research techniques necessary to begin an independent research career. The majority of supervision will be provided by Mark D. Markel, an internationally known and respected investigator in the area of thermal tissue modification, Professor of Surgery, and Professor and Chairman of Medical Sciences. The advisory committee will consist of well-respected and highly experienced individuals within the University. The Comparative Orthopaedic Research Laboratory is a well established laboratory that houses multi- disciplinary research programs. The University of Wisconsin provides an exceptional environment for interaction with experts in a variety of fields, and it is well known for its exceptional research programs, especially in the medical sciences.