MECHANISMS OF ANTIFOLATE EFFICACY

抗叶酸功效的机制

• 批准号: 6303017
• 负责人: SARAH LUISE MORGAN
• 金额: $ 2.95万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6303017
• 关键词: adenosine; clinical research; clinical trials; combination chemotherapy; folate; folate antagonist; human subject; human therapy evaluation; methotrexate; neurotransmitter metabolism; rheumatoid arthritis; tetrahydrofolates

This is a double-blind trial to evaluate the hypothesis that the beneficial effect of low-dose Methotrexate therapy in rheumatoid arthritis is due to the inhibition of aminoimidazole-carboxamide-ribotide transformylase, a folate-dependent enzyme which catalyzes the last step in the de novo biosynthesis of inosine monophosphate. Patients are supplemented in double-blindfashion with either folic and or folinic acid in a double-blind fashion and urinary levels of aminoimidazole carboxamide and adenosine are monitored.

这是一项双盲试验，旨在评估低剂量甲氨蝶呤治疗类风湿性关节炎的有益作用是由于抑制氨基咪唑-甲酰胺-核苷酸转化酶（一种叶酸依赖性酶，催化肌苷一磷酸从头生物合成的最后一步）的假设。 以双盲方式向患者补充叶酸和/或亚叶酸，并监测氨基咪唑甲酰胺和腺苷的尿水平。