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MICROSTIMULATION OF THE LUMBOSACRAL SPINAL CORD--CHRONI

腰骶脊髓的微刺激--CHRONI

基本信息

批准号：
6154525
负责人：
Douglas Buchanan McCreery
金额：
$ 35.47万
依托单位：
HUNTINGTON MEDICAL RESEARCH INSTITUTES
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-09-30 至 2001-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6154525
关键词：
Animalia bioengineering /biomedical engineering biomaterial interface interaction biomedical equipment development biomedical equipment safety clinical biomedical equipment implant lumbosacral region medical implant science microelectrodes molecular film neuromuscular stimulator spinal cord

项目摘要

The objective of this research is to explore the possibility of chronic microstimulation of the spinal cord. If successful, such a technique could be part of a prosthesis to restore genito-urinary, bowel and other motor functions to victims of spinal cord injury. Information from spinal cord microstimulation studies is especially needed by designers of neural prostheses for paraplegic individuals who have sustained injuries to their spinal cords above the lumbosacral region. In particular, it may be possible to selectively excite neurons innervating the bladder detrusor muscle while simultaneously stimulating interneurons which have inhibitory synaptic connections with neurons innervating the external urethral sphincter. Likewise, discrete control of penile erection, ejaculation, bowel evacuation and control of the somatic musculature of the limbs may be possible by selective spinal cord microstimulation below the level of spinal cord injury. Before microstimulation of the spinal cord can be evaluated in humans, a suitable chronic stimulating microelectrode must be developed and its safety and effectiveness demonstrated in animals. Contract supported research over the past five years has demonstrated that it is possible to insert, stimulate and maintain discrete wire microelectodes in the sacral spinal cord on a chronic basis without undue tissue damage. However, the present design of the microelectrode/lead wire system causes excessive mechanical damage during movement of the spinal cord within the spinal canal and must be improved. This new research project will complete the establishment of safe ranges of stimulation parameters and will investigate the use of thin film, integrated circuit microelectrodes in the lumbosacral spinal cord.

本研究的目的是探讨慢性病的可能性脊髓的微刺激。如果成功的话，这样的技术可以成为修复泌尿生殖系统、肠道和其他器官的假体的一部分脊髓损伤患者的运动功能。信息来自设计师尤其需要脊髓微刺激研究为截瘫患者提供神经假体腰骶部上方的脊髓受伤。在特别是，有可能选择性地兴奋支配神经的神经元同时刺激膀胱逼尿肌与神经元有抑制性突触连接的中间神经元支配尿道外括约肌。同样，离散控制阴茎勃起、射精、排便和控制四肢的躯体肌肉组织可能通过选择性脊柱脊髓损伤水平以下的脊髓微刺激。在对人类进行脊髓微刺激评估之前，必须开发一种合适的慢性刺激微电极及其在动物身上证明了安全性和有效性。支持合约过去五年的研究表明，这是可能的插入、刺激和维持离散的微电极慢性的骶脊髓没有过度的组织损伤。然而，目前微电极/导联线系统的设计在脊髓运动过程中造成过度机械损伤位于椎管内，必须加以改善。这个新的研究项目将完成刺激参数安全范围的建立并将研究薄膜、集成电路的使用腰骶脊髓中的微电极。