CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI

CLIN CTR WHI 临床试验/观察研究

• 批准号: 6081314
• 负责人: Jennifer Hays-Grudo
• 金额: $ 73.16万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2005-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6081314
• 关键词: breast neoplasms; calcium; clinical research; clinical trials; colorectal neoplasms; coronary disorder; diet; disease /disorder prevention /control; disease /disorder proneness /risk; estrogens; female; hip fractures; hormone therapy; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; longitudinal human study; nutrition related tag; osteoporosis; postmenopause; quality of life; questionnaires; stroke; therapy compliance; vitamin D; women's health

The Women's Health Initiative is a randomized controlled clinical trial conducted in 40 clinical centers across the United States addressing some of the most common causes of death, disability, and impaired quality of life in postmenopausal women ages 50-79: cardiovascular disease; breast and colon cancer; and osteoporosis. The three components of this disease prevention trial are: (1) hormone replacement therapy with a primary outcomes of coronary heart disease and stroke and secondary outcomes of hip and other fractures; (2) low fat dietary intervention with primary outcomes of breast cancer and colorectal cancer and a secondary outcome of coronary heart disease; and (3) calcium and vitamin D supplementation with a primary outcome of hip fractures and secondary outcomes of colorectal cancer and combined fractures. A concurrent observational study will provide estimates of health effects of known risk factors and new predictors for disease. Each clinical center will collect data through questionnaires and biological specimens over 8-12 years.

妇女健康计划是一项随机控制的临床 在美国的40个临床中心进行的试验 解决某些最常见的死亡，残疾原因和 50-79岁的绝经后妇女的生活质量受损： 心血管疾病；乳腺癌和结肠癌；和骨质疏松症。 该疾病预防试验的三个组成部分是：（1） 激素替代疗法与冠状动脉的主要结果 心脏病，中风以及髋关节和其他的次要结果 断裂； （2）低脂肪饮食干预措施 乳腺癌和结直肠癌以及次要结果 冠心病； （3）钙和维生素D 补充髋部骨折的主要结果和 结直肠癌和裂缝的次要结果。一个 并发观察研究将提供健康的估计 已知危险因素和疾病的新预测因素的影响。每个 临床中心将通过问卷调查收集数据 生物标本超过8 - 12年。