CIRCA, the Center for Integrative Research on Childhood Adversity

CIRCA，儿童逆境综合研究中心

• 批准号: 9924538
• 负责人: Jennifer Hays-Grudo
• 金额: $ 209.38万
• 依托单位: OSU CENTER FOR HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2022-09-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9924538
• 关键词: Academic Medical Centers; Accidental Injury; Address; Adolescent; Advisory Committees; African American; Alcohol consumption; Applied Research; Back; Behavioral; Behavioral Sciences; Biological Markers; Cause of Death; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Cessation of life; Child; Child Health; Childhood; Cities; Communities; Conceptions; Country; Disadvantaged; Environment; Ethnic Origin; Faculty; Foundations; Funding; Future; Goals; Health; Infant Mortality; Information Centers; Infrastructure; Latino; Link; Live Birth; Low Birth Weight Infant; Mentors; Methods; Modeling; Morbidity - disease rate; Obesity; Oklahoma; Outcome; Poverty; Pregnancy; Process; Progress Reports; Race; Reporting; Research; Research Personnel; Resources; Risk Factors; Schools; Science; Skin; Smoking; Social Sciences; Socioeconomic Status; Source; Students; Techniques; Thinking; Time; Training; Translating; Translational Research; United States National Institutes of Health; Universities; adolescent health; aged; base; bench to bedside; biobehavior; childhood adversity; design; ethnic minority population; fighting; health difference; health disparity; health equity; infant death; innovation; male; minority children; mortality; peer; public health relevance; racial minority; social; twelfth grade; young adult

 DESCRIPTION (provided by applicant): The proposed Center for Biomedical Research Excellence (CoBRE) will establish the Children's Health Equity Solutions Center (CHESC). The long-term goal of the CHESC is to eliminate unjust differences in children's health by race, ethnicity and socioeconomic status through effective translational science. The immediate goal of the CHESC is to build Oklahoma State University-Tulsa's research environment focused on discovering the sources of health inequities among children, and translating scientific results into solutions that eliminate children's health inequities. The CHESC's immediate goal will be achieved by accomplishing three specific aims, the CHESC will: 1) cultivate a cadre of independent researchers focused on discovering the bases for, and solutions to, children's health inequities; 2) establish the foundation and initial processes necessary to enable translational research focused on eliminating children's health inequities; and 3) build the scientific infrastructure needed to harness the growing field of available biomarkers and analytic techniques needed to delineate the bio-behavioral mechanisms linking the origins and outcomes of children's health inequities. The CHESC will be placed in Tulsa, OK: the nation's 46th largest city - yet lacks a comprehensive research university or major academic medical center, a community with remarkable children's health disparities, and in a state that consistently scores among the 10 worst states in the US in terms of child health outcomes. The CHESC will consist of an Administrative Core and a Methods Core led by an established NIH investigator and mentor and an Executive Committee (EC) of four additional established investigators or well-trained mentors. The EC will solicit advice annually from an exemplary External Advisory Committee (EAC), and (at least) quarterly advice from an Internal Advisory Committee (IAC). An expert external evaluator will provide semiannual and annual progress reports to the EC, EAC, and IAC. The CHESC will support and train three promising emerging investigators and transition them into independent status. The CHESC is significant; its focus on identifying solutions for children's health inequities addresses a critical barrier to achieving a national priority. The CHESC is innovative. Research centers focused on health disparities and inequities exist throughout the country; however, none of these centers focus specifically on children's health inequities.

 描述（由申请人提供）：拟议的生物医学研究卓越中心（CoBRE）将建立儿童健康公平解决方案中心（CHESC）。CHESC的长期目标是通过有效的转化科学消除儿童健康因种族、族裔和社会经济地位而存在的不公正差异。CHESC的近期目标是建立俄克拉荷马州塔尔萨州立大学的研究环境，重点是发现儿童健康不平等的根源，并将科学成果转化为消除儿童健康不平等的解决方案。CHESC的近期目标将通过实现三个具体目标来实现，CHESC将：1）培养一支独立的研究人员队伍，专注于发现儿童健康不公平的基础和解决方案; 2）建立必要的基础和初始流程，以实现专注于消除儿童健康不公平的转化研究;以及3）建立科学基础设施，以利用日益增长的可用生物标志物和分析技术，以描述将儿童健康不平等的起源和结果联系起来的生物行为机制。CHESC将被放置在塔尔萨，OK：全国第46大城市-但缺乏一个综合性的研究型大学或主要的学术医疗中心，一个社区有显着的儿童健康差距，并在一个国家，一直得分在美国10个最差的国家在儿童健康结果方面。CHESC将由一个行政核心和一个方法核心组成，由一名既定的NIH研究者和导师领导，以及一个由四名额外的既定研究者或训练有素的导师组成的执行委员会（EC）。委员会将每年从一个示范性的外部咨询委员会（EAC）征求意见，并（至少）每季度从一个内部咨询委员会（IAC）征求意见。一名外部专家评估员将向EC、EAC和IAC提供半年度和年度进展报告。CHESC将支持和培训三名有前途的新兴研究人员，并将他们转变为独立的研究人员。CHESC意义重大;它的重点是确定解决儿童健康不平等问题的办法，这解决了实现国家优先事项的一个关键障碍。CHESC是创新的。全国各地都有关注健康差距和不平等的研究中心;然而，这些中心都没有专门关注儿童的健康不平等。