Center for Integrative Research on Childhood Adversity

童年逆境综合研究中心

• 批准号: 10697315
• 负责人: Jennifer Hays-Grudo
• 金额: $ 188.71万
• 依托单位: OSU CENTER FOR HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10697315
• 关键词: Address; Adolescent; Advisory Committees; Affect; Anterior; Behavior; Behavioral; Biological; Brain region; COVID-19 impact; Cells; Centers of Research Excellence; Collaborations; Collection; Communities; Daughter; Dendritic Cells; Development; Developmental Process; Endocrine; Equipment; Faculty; Functional Magnetic Resonance Imaging; Funding; Future; Gene Expression; Generations; Genes; Genetic; Glucocorticoids; Goals; Grant; Growth; Health; Health Promotion; Health Sciences; Healthcare; Human Development; Hydrocortisone; Immune; Immune system; Infrastructure; Institution; Investments; Knowledge; Life Cycle Stages; Link; Mental Health; Mental disorders; Mentors; Metabolic; Methylation; Mothers; NR3C1 gene; North America; Oklahoma; Organizational Affiliation; Outcome; Pathway interactions; Perinatal; Phase; Pilot Projects; Prevention; Process; Protocols documentation; Public Health; Recording of previous events; Recovery; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Science; Scientist; Substance abuse problem; System; Time; Training; Trauma; United States National Institutes of Health; Universities; adverse childhood events; behavior measurement; biobehavior; biological systems; career; childhood adversity; cost; data repository; design; early life adversity; efficacy testing; emotion regulation; epidemiologic data; experience; experimental study; healing; infancy; innovation; intergenerational; monocyte; multidisciplinary; neurobiological mechanism; neurofeedback; physical conditioning; prevent; programs; promote resilience; protective factors; recruit; resilience; stress reactivity; transmission process; vaccine efficacy

ABSTRACT The goal of this Phase 2 CoBRE application is to expand on the accomplishments of Phase 1 in establishing an interdisciplinary and translational Center for Integrative Research on Childhood Adversity (CIRCA) at Oklahoma State University (OSU). Two decades of epidemiological data document that Adverse Childhood Experiences (ACEs) are prevalent and cumulative, have enduring negative consequences for physical and mental health, and cost north America more than $758B in preventable health care. In order to reduce the costly effects of ACEs, research is increasingly focused on identifying mechanisms and processes by which ACEs impact developing nervous, endocrine, metabolic, and immune systems, and intergenerational biobehavioral pathways of transmission, as well as potential pathways for prevention, recovery, and healing. This research is interdisciplinary by design and reliant on a team science approach, requiring researchers with the capacity to collaborate in transdisciplinary teams.14, 15 The goals of CIRCA during Phase 1 were to increase institutional research infrastructure to support a cadre of collaborative investigators achieve independent funding on adversity and resilience. OSU invested approximately $10M in facilities, equipment, faculty, and staff, significantly increasing capacity for biobehavioral research on adversity. The 5 research project leaders (RPLs) and 8 pilot project leaders in Phase 1 obtained $16.3M in external grant support, with an $8.2M increase in NIH funding. Phase 2 will expand and strengthen this interdisciplinary and collaborative center of biomedical research excellence by a) building institutional and center infrastructure using a team science approach; b) supporting and mentoring early-career investigators in their programs of research; c) developing vibrant, sustainable research cores; and d) generating innovative transdisciplinary approaches focused on the synergistic impacts of genetic, biological, environmental, and developmental influences on risk and resilience over the life course. Phase 2 projects will investigate neurobiological mechanisms and developmental processes linking childhood adversity with subsequent health problems using a theoretical framework developed by CIRCA investigators during Phase 1. The proposed research projects and planned pilot projects will be supported by an Administrative Core, a Recruitment, Engagement, Collection, and Assessment (RECA) Core and a Biological Systems Core. Each project will contribute to a common set of biological and behavioral measures, establishing a sustainable CIRCA Databank for current and future research. This proposed Phase 2 CoBRE is highly innovative in that it addresses the need to prepare a new generation of scientists with the capacity to identify and target the biobehavioral and developmental processes linking early life adversity with negative health outcomes. It is significant in that it will create a sustainable center providing opportunities for collaboration and a biobehavioral databank for current and future investigators in a region characterized by high rates of ACEs and historical trauma.

摘要 第二阶段的目标是在第一阶段的基础上， 一个跨学科和翻译中心的综合研究儿童逆境（CIRCA）在 俄克拉荷马州州立大学（OSU）。20年的流行病学数据表明， 经验（ACE）是普遍的和累积的，对身体和精神健康具有持久的负面影响。 心理健康，并花费了北美超过7580亿美元的可预防医疗保健。为了减少 ACE的昂贵影响，研究越来越多地集中在确定机制和过程， ACE影响发育中的神经、内分泌、代谢和免疫系统， 传播的生物行为途径，以及预防，恢复和愈合的潜在途径。 这项研究是跨学科的设计和依赖于团队科学的方法，需要研究人员与 在跨学科团队中合作的能力。14，15 CIRCA在第一阶段的目标是 增加机构研究基础设施，以支持一批合作调查人员， 逆境和复原力的独立资助。俄勒冈州立大学在设施，设备， 教师和工作人员，显着提高逆境生物行为研究的能力。5研究 第一阶段的项目负责人（RPL）和8名试点项目负责人获得了1630万美元的外部赠款支持， 增加了820万美元的NIH资金。第二阶段将扩大和加强这一跨学科和合作 卓越的生物医学研究中心，通过a）使用团队建立机构和中心基础设施 科学方法; B）支持和指导早期职业调查人员的研究计划; c） 发展充满活力的、可持续的研究核心;以及d）产生创新的跨学科方法 重点关注遗传、生物、环境和发育对风险的协同影响 和恢复力。第二阶段项目将研究神经生物学机制， 发展过程联系童年逆境与随后的健康问题，使用理论 CIRCA研究人员在第1阶段制定的框架。拟议的研究项目和计划 试点项目将由一个行政核心，一个招聘，参与，收集，和 评估（RECA）核心和生物系统核心。每个项目都将有助于一套共同的 生物和行为措施，建立一个可持续的CIRCA数据库，为当前和未来 research.这个提议的第二阶段CoBRE是高度创新的，因为它解决了准备一个新的 培养有能力识别和瞄准生物行为和发育过程的科学家 将早期生活逆境与负面健康结果联系起来。它的重要性在于它将创造一个可持续的 中心提供合作的机会和生物行为数据库，为当前和未来 研究人员在一个地区的特点是高利率的ACE和历史创伤。

项目成果

The Impact of the COVID-19 Pandemic on Adolescent Emotional, Social, and Academic Adjustment.

COVID-19 大流行对青少年情绪、社会和学业调整的影响。

• DOI: 10.1111/jora.12668
• 发表时间: 2021-09
• 期刊: Journal of research on adolescence : the official journal of the Society for Research on Adolescence
• 作者: Branje S;Morris AS
• 通讯作者: Morris AS

Infant sleep and negative reactivity: The role of maternal adversity and perinatal sleep.

• DOI: 10.1016/j.infbeh.2021.101664
• 发表时间: 2022-03
• 期刊: INFANT BEHAVIOR & DEVELOPMENT
• 影响因子: 2.1
• 作者: Ciciolla, Lucia;Addante, Samantha;Quigley, Ashley;Erato, Gina;Fields, Kristin
• 通讯作者: Fields, Kristin

Maternal Adverse Childhood Experiences and Perceived Stress During Pregnancy: The Role of Personality.

母亲不良的童年经历和怀孕期间感受到的压力：人格的作用。

• DOI: 10.1007/s40653-023-00525-1
• 发表时间: 2023
• 期刊: Journal of child & adolescent trauma
• 影响因子: 1.5
• 作者: Fields,Kristin;Ciciolla,Lucia;Addante,Samantha;Erato,Gina;Quigley,Ashley;Mullins-Sweatt,StephanieN;Shreffler,KarinaM
• 通讯作者: Shreffler,KarinaM

Trends in public interest in child abuse in the United States: An infodemiology study of Google Trends from 2004 to 2022.

美国公众对虐待儿童问题的兴趣趋势：2004 年至 2022 年 Google 趋势的信息流行病学研究。

• DOI: 10.1016/j.chiabu.2022.105868
• 发表时间: 2022
• 期刊: Child abuse & neglect
• 影响因子: 4.8
• 作者: Hartwell,Micah;Hendrix-Dicken,AmyD;Sajjadi,NicholasB;Bloom,Molly;Gooch,Trey;Conway,Lauren;Baxter,MichaelA
• 通讯作者: Baxter,MichaelA

Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men.

抵抗运动可以减弱年轻和老年男性对高脂肪膳食的餐后代谢反应。

• DOI: 10.1016/j.nutres.2020.08.012
• 发表时间: 2020
• 期刊: Nutrition research (New York, N.Y.)
• 作者: Jenkins,NathanielDM;Banks,NileF;Rogers,EmilyM;Sciarrillo,ChristinaM;Koemel,NicholasA;Colquhoun,RyanJ;Emerson,SamR
• 通讯作者: Emerson,SamR