Center for Integrative Research on Childhood Adversity

童年逆境综合研究中心

• 批准号: 10697315
• 负责人: Jennifer Hays-Grudo
• 金额: $ 188.71万
• 依托单位: OSU CENTER FOR HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10697315
• 关键词: Address; Adolescent; Advisory Committees; Affect; Anterior; Behavior; Behavioral; Biological; Brain region; COVID-19 impact; Cells; Centers of Research Excellence; Collaborations; Collection; Communities; Daughter; Dendritic Cells; Development; Developmental Process; Endocrine; Equipment; Faculty; Functional Magnetic Resonance Imaging; Funding; Future; Gene Expression; Generations; Genes; Genetic; Glucocorticoids; Goals; Grant; Growth; Health; Health Promotion; Health Sciences; Healthcare; Human Development; Hydrocortisone; Immune; Immune system; Infrastructure; Institution; Investments; Knowledge; Life Cycle Stages; Link; Mental Health; Mental disorders; Mentors; Metabolic; Methylation; Mothers; NR3C1 gene; North America; Oklahoma; Organizational Affiliation; Outcome; Pathway interactions; Perinatal; Phase; Pilot Projects; Prevention; Process; Protocols documentation; Public Health; Recording of previous events; Recovery; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Science; Scientist; Substance abuse problem; System; Time; Training; Trauma; United States National Institutes of Health; Universities; adverse childhood events; behavior measurement; biobehavior; biological systems; career; childhood adversity; cost; data repository; design; early life adversity; efficacy testing; emotion regulation; epidemiologic data; experience; experimental study; healing; infancy; innovation; intergenerational; monocyte; multidisciplinary; neurobiological mechanism; neurofeedback; physical conditioning; prevent; programs; promote resilience; protective factors; recruit; resilience; stress reactivity; transmission process; vaccine efficacy

ABSTRACT The goal of this Phase 2 CoBRE application is to expand on the accomplishments of Phase 1 in establishing an interdisciplinary and translational Center for Integrative Research on Childhood Adversity (CIRCA) at Oklahoma State University (OSU). Two decades of epidemiological data document that Adverse Childhood Experiences (ACEs) are prevalent and cumulative, have enduring negative consequences for physical and mental health, and cost north America more than $758B in preventable health care. In order to reduce the costly effects of ACEs, research is increasingly focused on identifying mechanisms and processes by which ACEs impact developing nervous, endocrine, metabolic, and immune systems, and intergenerational biobehavioral pathways of transmission, as well as potential pathways for prevention, recovery, and healing. This research is interdisciplinary by design and reliant on a team science approach, requiring researchers with the capacity to collaborate in transdisciplinary teams.14, 15 The goals of CIRCA during Phase 1 were to increase institutional research infrastructure to support a cadre of collaborative investigators achieve independent funding on adversity and resilience. OSU invested approximately $10M in facilities, equipment, faculty, and staff, significantly increasing capacity for biobehavioral research on adversity. The 5 research project leaders (RPLs) and 8 pilot project leaders in Phase 1 obtained $16.3M in external grant support, with an $8.2M increase in NIH funding. Phase 2 will expand and strengthen this interdisciplinary and collaborative center of biomedical research excellence by a) building institutional and center infrastructure using a team science approach; b) supporting and mentoring early-career investigators in their programs of research; c) developing vibrant, sustainable research cores; and d) generating innovative transdisciplinary approaches focused on the synergistic impacts of genetic, biological, environmental, and developmental influences on risk and resilience over the life course. Phase 2 projects will investigate neurobiological mechanisms and developmental processes linking childhood adversity with subsequent health problems using a theoretical framework developed by CIRCA investigators during Phase 1. The proposed research projects and planned pilot projects will be supported by an Administrative Core, a Recruitment, Engagement, Collection, and Assessment (RECA) Core and a Biological Systems Core. Each project will contribute to a common set of biological and behavioral measures, establishing a sustainable CIRCA Databank for current and future research. This proposed Phase 2 CoBRE is highly innovative in that it addresses the need to prepare a new generation of scientists with the capacity to identify and target the biobehavioral and developmental processes linking early life adversity with negative health outcomes. It is significant in that it will create a sustainable center providing opportunities for collaboration and a biobehavioral databank for current and future investigators in a region characterized by high rates of ACEs and historical trauma.

摘要

项目成果

The Impact of the COVID-19 Pandemic on Adolescent Emotional, Social, and Academic Adjustment.

COVID-19 大流行对青少年情绪、社会和学业调整的影响。

• DOI: 10.1111/jora.12668
• 发表时间: 2021-09
• 期刊: Journal of research on adolescence : the official journal of the Society for Research on Adolescence
• 作者: Branje S;Morris AS
• 通讯作者: Morris AS

Infant sleep and negative reactivity: The role of maternal adversity and perinatal sleep.

• DOI: 10.1016/j.infbeh.2021.101664
• 发表时间: 2022-03
• 期刊: INFANT BEHAVIOR & DEVELOPMENT
• 影响因子: 2.1
• 作者: Ciciolla, Lucia;Addante, Samantha;Quigley, Ashley;Erato, Gina;Fields, Kristin
• 通讯作者: Fields, Kristin

Maternal Adverse Childhood Experiences and Perceived Stress During Pregnancy: The Role of Personality.

母亲不良的童年经历和怀孕期间感受到的压力：人格的作用。

• DOI: 10.1007/s40653-023-00525-1
• 发表时间: 2023
• 期刊: Journal of child & adolescent trauma
• 影响因子: 1.5
• 作者: Fields,Kristin;Ciciolla,Lucia;Addante,Samantha;Erato,Gina;Quigley,Ashley;Mullins-Sweatt,StephanieN;Shreffler,KarinaM
• 通讯作者: Shreffler,KarinaM

Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men.

抵抗运动可以减弱年轻和老年男性对高脂肪膳食的餐后代谢反应。

• DOI: 10.1016/j.nutres.2020.08.012
• 发表时间: 2020
• 期刊: Nutrition research (New York, N.Y.)
• 作者: Jenkins,NathanielDM;Banks,NileF;Rogers,EmilyM;Sciarrillo,ChristinaM;Koemel,NicholasA;Colquhoun,RyanJ;Emerson,SamR
• 通讯作者: Emerson,SamR

Trends in public interest in child abuse in the United States: An infodemiology study of Google Trends from 2004 to 2022.

美国公众对虐待儿童问题的兴趣趋势：2004 年至 2022 年 Google 趋势的信息流行病学研究。

• DOI: 10.1016/j.chiabu.2022.105868
• 发表时间: 2022
• 期刊: Child abuse & neglect
• 影响因子: 4.8
• 作者: Hartwell,Micah;Hendrix-Dicken,AmyD;Sajjadi,NicholasB;Bloom,Molly;Gooch,Trey;Conway,Lauren;Baxter,MichaelA
• 通讯作者: Baxter,MichaelA