Center for Integrative Research on Childhood Adversity

童年逆境综合研究中心

• 批准号: 10697315
• 负责人: Jennifer Hays-Grudo
• 金额: $ 188.71万
• 依托单位: OSU CENTER FOR HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10697315
• 关键词: Address; Adolescent; Advisory Committees; Affect; Anterior; Behavior; Behavioral; Biological; Brain region; COVID-19 impact; Cells; Centers of Research Excellence; Collaborations; Collection; Communities; Daughter; Dendritic Cells; Development; Developmental Process; Endocrine; Equipment; Faculty; Functional Magnetic Resonance Imaging; Funding; Future; Gene Expression; Generations; Genes; Genetic; Glucocorticoids; Goals; Grant; Growth; Health; Health Promotion; Health Sciences; Healthcare; Human Development; Hydrocortisone; Immune; Immune system; Infrastructure; Institution; Investments; Knowledge; Life Cycle Stages; Link; Mental Health; Mental disorders; Mentors; Metabolic; Methylation; Mothers; NR3C1 gene; North America; Oklahoma; Organizational Affiliation; Outcome; Pathway interactions; Perinatal; Phase; Pilot Projects; Prevention; Process; Protocols documentation; Public Health; Recording of previous events; Recovery; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Science; Scientist; Substance abuse problem; System; Time; Training; Trauma; United States National Institutes of Health; Universities; adverse childhood events; behavior measurement; biobehavior; biological systems; career; childhood adversity; cost; data repository; design; early life adversity; efficacy testing; emotion regulation; epidemiologic data; experience; experimental study; healing; infancy; innovation; intergenerational; monocyte; multidisciplinary; neurobiological mechanism; neurofeedback; physical conditioning; prevent; programs; promote resilience; protective factors; recruit; resilience; stress reactivity; transmission process; vaccine efficacy

ABSTRACT The goal of this Phase 2 CoBRE application is to expand on the accomplishments of Phase 1 in establishing an interdisciplinary and translational Center for Integrative Research on Childhood Adversity (CIRCA) at Oklahoma State University (OSU). Two decades of epidemiological data document that Adverse Childhood Experiences (ACEs) are prevalent and cumulative, have enduring negative consequences for physical and mental health, and cost north America more than $758B in preventable health care. In order to reduce the costly effects of ACEs, research is increasingly focused on identifying mechanisms and processes by which ACEs impact developing nervous, endocrine, metabolic, and immune systems, and intergenerational biobehavioral pathways of transmission, as well as potential pathways for prevention, recovery, and healing. This research is interdisciplinary by design and reliant on a team science approach, requiring researchers with the capacity to collaborate in transdisciplinary teams.14, 15 The goals of CIRCA during Phase 1 were to increase institutional research infrastructure to support a cadre of collaborative investigators achieve independent funding on adversity and resilience. OSU invested approximately $10M in facilities, equipment, faculty, and staff, significantly increasing capacity for biobehavioral research on adversity. The 5 research project leaders (RPLs) and 8 pilot project leaders in Phase 1 obtained $16.3M in external grant support, with an $8.2M increase in NIH funding. Phase 2 will expand and strengthen this interdisciplinary and collaborative center of biomedical research excellence by a) building institutional and center infrastructure using a team science approach; b) supporting and mentoring early-career investigators in their programs of research; c) developing vibrant, sustainable research cores; and d) generating innovative transdisciplinary approaches focused on the synergistic impacts of genetic, biological, environmental, and developmental influences on risk and resilience over the life course. Phase 2 projects will investigate neurobiological mechanisms and developmental processes linking childhood adversity with subsequent health problems using a theoretical framework developed by CIRCA investigators during Phase 1. The proposed research projects and planned pilot projects will be supported by an Administrative Core, a Recruitment, Engagement, Collection, and Assessment (RECA) Core and a Biological Systems Core. Each project will contribute to a common set of biological and behavioral measures, establishing a sustainable CIRCA Databank for current and future research. This proposed Phase 2 CoBRE is highly innovative in that it addresses the need to prepare a new generation of scientists with the capacity to identify and target the biobehavioral and developmental processes linking early life adversity with negative health outcomes. It is significant in that it will create a sustainable center providing opportunities for collaboration and a biobehavioral databank for current and future investigators in a region characterized by high rates of ACEs and historical trauma.

抽象的 该第2阶段毛线应用的目的是扩大建立阶段1的成就 关于儿童逆境综合研究（大约）的跨学科和转化中心 俄克拉荷马州立大学（OSU）。二十年的流行病学数据文档不利的童年 经验（ACE）普遍且累积，对身体和身体产生负面影响 心理健康，北美耗资超过$ 758B的可预防医疗保健。为了减少 ACE的昂贵影响，研究越来越集中于确定机制和过程 ACE会影响发展神经，内分泌，代谢和免疫系统以及代际 传播的生物行为途径以及预防，恢复和康复的潜在途径。 这项研究是通过设计跨学科的，并依赖于团队科学方法，要求研究人员 在跨学科团队中合作的能力。14，15阶段15的目标是 增加机构研究基础设施，以支持一大批合作研究者 逆境和韧性的独立资金。 OSU投资了约1000万美元的设施，设备， 教职员工和教职员工大大提高了逆境研究生物行为研究的能力。 5个研究 第1阶段的项目负责人（RPLS）和8位试点项目负责人获得了1630万美元的外部赠款支持，并带有 NIH资金增加了820万美元。第2阶段将扩展和加强这种跨学科和协作 a）使用团队建立机构和中心基础设施的生物医学研究中心 科学方法； b）支持和指导早期研究人员的研究计划； c） 发展充满活力的可持续研究核心； d）产生创新的跨学科方法 专注于遗传，生物学，环境和发育对风险的协同影响 以及对生活过程中的韧性。第二阶段项目将研究神经生物学机制和 使用理论的发展过程将儿童逆境与随后的健康问题联系起来 大约研究人员在第1阶段开发的框架。拟议的研究项目并计划 试点项目将得到行政核心的支持，招聘，参与，收集和 评估（RECA）核心和生物系统核心。每个项目都会有助于一组 生物学和行为措施，为当前和未来建立可持续的大约数据库 研究。该提议的第2阶段毛线具有很高的创新性，因为它解决了准备新的需求 产生具有识别和针对生物行为和发育过程的能力的科学家 将早期逆境与负面健康结果联系起来。这很重要，因为它将创造一个可持续的 中心为当前和未来提供合作的机会和生物行为数据库 以高速杆和历史创伤为特征的地区的研究人员。

项目成果

Infant sleep and negative reactivity: The role of maternal adversity and perinatal sleep.

• DOI: 10.1016/j.infbeh.2021.101664
• 发表时间: 2022-03
• 期刊: INFANT BEHAVIOR & DEVELOPMENT
• 影响因子: 2.1
• 作者: Ciciolla, Lucia;Addante, Samantha;Quigley, Ashley;Erato, Gina;Fields, Kristin
• 通讯作者: Fields, Kristin

Maternal Adverse Childhood Experiences and Perceived Stress During Pregnancy: The Role of Personality.

母亲不良的童年经历和怀孕期间感受到的压力：人格的作用。

• DOI: 10.1007/s40653-023-00525-1
• 发表时间: 2023
• 期刊: Journal of child & adolescent trauma
• 影响因子: 1.5
• 作者: Fields,Kristin;Ciciolla,Lucia;Addante,Samantha;Erato,Gina;Quigley,Ashley;Mullins-Sweatt,StephanieN;Shreffler,KarinaM
• 通讯作者: Shreffler,KarinaM

Trends in public interest in child abuse in the United States: An infodemiology study of Google Trends from 2004 to 2022.

美国公众对虐待儿童问题的兴趣趋势：2004 年至 2022 年 Google 趋势的信息流行病学研究。

• DOI: 10.1016/j.chiabu.2022.105868
• 发表时间: 2022
• 期刊: Child abuse & neglect
• 影响因子: 4.8
• 作者: Hartwell,Micah;Hendrix-Dicken,AmyD;Sajjadi,NicholasB;Bloom,Molly;Gooch,Trey;Conway,Lauren;Baxter,MichaelA
• 通讯作者: Baxter,MichaelA

Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men.

抵抗运动可以减弱年轻和老年男性对高脂肪膳食的餐后代谢反应。

• DOI: 10.1016/j.nutres.2020.08.012
• 发表时间: 2020
• 期刊: Nutrition research (New York, N.Y.)
• 作者: Jenkins,NathanielDM;Banks,NileF;Rogers,EmilyM;Sciarrillo,ChristinaM;Koemel,NicholasA;Colquhoun,RyanJ;Emerson,SamR
• 通讯作者: Emerson,SamR

The Impact of the COVID-19 Pandemic on Adolescent Emotional, Social, and Academic Adjustment.

COVID-19 大流行对青少年情绪、社会和学业调整的影响。

• DOI: 10.1111/jora.12668
• 发表时间: 2021-09
• 期刊: Journal of research on adolescence : the official journal of the Society for Research on Adolescence
• 作者: Branje S;Morris AS
• 通讯作者: Morris AS