CORE--DATA MANAGEMENT AND STATISTICS

1)核心单元的数据管理部分提供采集， 存储和检索中心所有单位的数据。 2)核心单位的统计科向所有人提供专业知识 调查人员对研究进行分析和解释。 数据管理股提供广泛的计算机设施，包括 与长老会医院和哥伦比亚大学主校园的链接 电脑。单位每天从医院电脑下载所有 与患者和设备有关的临床和实验室数据 对所有患者的病历进行详细总结。世界银行的一个重要目标 统计切片的核心单元是生成预后因素， 从我们自己对数百名患者的数据中，通过相关性 遗传修饰物和血液学资料与临床表现 这种疾病的危害。证明相对较低的HGB门槛 F浓度(大于或等于4%)提供防护 中风还表明，可能增加HGB F浓度的药物可能 导致预防这种和其他破坏性的镰刀并发症 细胞疾病。将产生更复杂和更全面的图景 提供详细的预后因素，可用于选择性地 计划针对特定的患者提供治疗方法。

1)The data management section of the core unit provides collection, storage and retrieval of data from all units of the center. 2) The statistical section of the core unit offers expertise to all investigators for analysis and interpretation of studies. The data management unit provides an extensive computer facility, with links to both the Presbyterian Hospital and the Columbia main campus computers. The unit downloads daily from the hospital computer all clinical and laboratory data relative to the patients and furnishes detailed summary to all patients' charts. An important goal of the statistical section of the core unit is to generate prognostic factors, from our own data on several hundred patients, by correlation of the genetic modifiers and hematological data with the clinical manifestations of the disease. The demonstration that a relatively low threshold of Hgb F concentration (greater than or equal to 4%) confers protection from stroke also suggests that drugs that may increase Hgb F concentration may result in prevention of this and other devastating complications of sickle cell diseases. A more complex and comprehensive picture will be generated to provide detailed prognostic factors that could be used to selectively program to specific patients that available therapies.