CORE--DATA MANAGEMENT AND STATISTICS

核心——数据管理与统计

• 批准号: 6109608
• 负责人: SERGIO S PIOMELLI
• 金额: $ 13.55万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-06 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6109608
• 关键词: biomedical facility; data collection methodology /evaluation; data management; human data; information systems; sickle cell anemia; statistics /biometry

1)The data management section of the core unit provides collection, storage and retrieval of data from all units of the center. 2) The statistical section of the core unit offers expertise to all investigators for analysis and interpretation of studies. The data management unit provides an extensive computer facility, with links to both the Presbyterian Hospital and the Columbia main campus computers. The unit downloads daily from the hospital computer all clinical and laboratory data relative to the patients and furnishes detailed summary to all patients' charts. An important goal of the statistical section of the core unit is to generate prognostic factors, from our own data on several hundred patients, by correlation of the genetic modifiers and hematological data with the clinical manifestations of the disease. The demonstration that a relatively low threshold of Hgb F concentration (greater than or equal to 4%) confers protection from stroke also suggests that drugs that may increase Hgb F concentration may result in prevention of this and other devastating complications of sickle cell diseases. A more complex and comprehensive picture will be generated to provide detailed prognostic factors that could be used to selectively program to specific patients that available therapies.

1）核心单元的数据管理部分提供采集、 存储和检索中心所有单位的数据。 2) 核心单位的统计部分为所有人提供专业知识 研究人员对研究进行分析和解释。 数据管理单元提供了广泛的计算机设施， 连接长老会医院和哥伦比亚主校区 电脑。该装置每天从医院计算机下载所有 与患者相关的临床和实验室数据并提供 所有患者图表的详细摘要。该组织的一个重要目标是 统计部分的核心单元是生成预后因素， 根据我们自己对数百名患者的数据，通过相关性 遗传修饰和血液学数据与临床表现 的疾病。证明 Hgb 阈值相对较低 F 浓度（大于或等于 4%）可提供保护 中风还表明，可能增加 Hgb F 浓度的药物可能 从而预防镰状细胞病的这种和其他破坏性并发症 细胞疾病。将生成更复杂、更全面的图景 提供详细的预后因素，可用于选择性地 为特定患者制定可用疗法的计划。