COMPREHENSIVE SICKLE CELL CENTER

哥伦比亚大学综合镰状细胞中心包括 内科医生和外科医生学院的科学资源， 其3家主要医院的临床资源：长老会医院、圣。 卢克/罗斯福和哈莱姆医院 该中心将继续提供优质的临床护理，筛查， 遗传咨询、产前诊断和教育， 在曼哈顿的上半区，病人最集中的地方 患有镰状细胞病（SCD）的人和他们的家人。 该中心将包括8个研究单位，3个临床单位（各一个 医院和2个核心单位。 研究单位将专门 致力于研究;临床单位还将提供临床 护理、筛查和教育。 研究领域如下： β-珠蛋白基因的转移， HgbS转基因小鼠的制备与研究 HgbS分子的相互作用和聚集， SCD中的红细胞生成前体， SCD中的微血管功能， SCD中的脑血管循环， SCD的神经系统受累， 骨髓移植治疗SCD 两个核心单位还将提供分子生物学分析，产前 诊断、血液学检测、数据管理、统计和 局 该中心的目标是促进在该领域的知识， 镰状细胞病，并提供一个环境， 各种研究项目所产生的领域可能会带来 立即给病人。

The Comprehensive Sickle Cell Center of Columbia University includes the scientific resources of the College of Physicians and Surgeons and the clinical resources of its 3 main hospitals: Presbyterian, St. Luke's/Roosevelt and Harlem Hospital. The Center will continue to provide excellent clinical care, screening, genetic counseling, prenatal diagnosis and education to the community of the upper part of Manhattan, where the largest concentration of patients with sickle cell diseases (SCD) and their families live. The Center will include 8 research units, 3 clinical units (one at each hospital) and 2 core units. The research units will be exclusively dedicated to research; the clinical units will also provide clinical care, screening and education. The areas of research will be the following: Transfer of the beta-globin gene, Production and study of transgenic mice containing HgbS, Interactions and aggregation of HgbS molecules, Erythropoietic precursors in SCD, Microvascular function in SCD, Cerebro-vascular circulation in SCD, Neurological involvement in SCD, Bone marrow transplantation in SCD. Two core units will also provide molecular biology analysis, prenatal diagnosis, hematological testing, data management, statistics and administration. The goal of the Center is to foster improved knowledge in the area of sickle cell diseases and to provide an environment where the advances in the field generated by the various research projects may be brought immediately to the patients.