COMPREHENSIVE SICKLE CELL CENTER OF MANHATTAN

曼哈顿的综合镰状细胞中心是一个由2个 医学院（哥伦比亚和Mt.西奈）和4家医院（长老会， 圣路克-罗斯福，哈莱姆和山。Sinai）。患者人群 服务对象为900人，几乎是岛上所有的患者 患有镰状细胞病的曼哈顿居民。 该中心的临床单位提供“最先进的”个性化 临床护理的病人，谁，反过来，参与各种 研究项目。 中心研究活动的一个主要目标是： 从分子生物学角度研究疾病 基因转移的目标是在动物和体外进行的， 血红蛋白转换的控制和作为转基因小鼠的创建 疾病的动物模型作为平行的方法。病人 通过DNA分析和基因型进行详细的遗传分类 与临床表现和血液学数据相关， 可用于靶向治疗的预后因素。 该中心的另一个领域侧重于治疗：使用间歇性 丁酸盐疗法提供了增加Hgb F的希望（已经显示 该中心的另一个单位认为，HgbF百分比低至>4%， 防止中风）。另一种治疗方法是 慢性输血病人口服铁螯合剂。研究 神经心理损伤与体液研究相关， 反映内皮损伤的分子和整合的 微循环的“体内”研究。 该中心旨在为所有项目提供凝聚力和协同作用。中心 是由一个行政和统计核心，我的分子， 生物学和血液学实验室核心，并通过红细胞生成 实验室核心

The Comprehensive Sickle Cell Center of Manhattan is a consortium of 2 medical schools (Columbia and Mt. Sinai) and 4 hospitals (Presbyterian, St. Luke's-Roosevelt, Harlem and Mt. Sinai). The population of patients served consists of 900 individuals, nearly all the patients in the island of Manhattan with sickle cell diseases. The clinical units of the Center provide "state-of-the art" personalized clinical care to the patients, who, in turn, participate in a variety of research projects. One main goal of research activities of the Center focuses on the molecular biology approach to the disease The gene transfer goal is pursued in animals and in vitro, with the control of hemoglobin switching and the creation of transgenic mice as an animal model of the disease as parallel approaches. The patients are genetically classified in detail by DNA analysis and their genotype correlated with clinical manifestation and hematological data to derive prognostic factors that could be used to target therapy. Another area of the Center focuses on therapy: the use of intermittent butyrate therapy offers the promise of increasing Hgb F (it has been shown by another unit of the Center that a HgbF percentage as low as >4% is protective against stroke). Another therapeutic approach is the trial of oral Fe chelator for the patients on chronic transfusion. Studies of neuropsychological damage are correlated with humoral studies of coagulation and of molecules reflecting endothelial damage and integrated with "in vivo" studies of microcirculation. The Center aims to provide cohesion and synergy to all project. The center is assisted by an administrative and statistical core, my a molecular biology and hematological laboratory core, and by an erythropoiesis laboratory core.