ACTIVE FILTERING IN THE COCHLEA

这项拟议研究的长期目标是确认外毛 细胞负责耳蜗机电放大。 并阐明这种扩增的潜在机制。这个 该提案的具体目标是确定 Corti器官负责耳蜗频率图，以 确定OHC是如何放大行波的，以确定 耳蜗区的运动与IHC立体纤毛运动相耦合， 并确定耳声发射与耳蜗区的关系 动议。为了实现这些目标，调查人员将测量 细胞和胞外元件的机械阻抗 科尔蒂器官，以成像科尔蒂器官元素的运动 作为对切除耳蜗电和机械刺激的响应， 同时测量耳蜗基底膜运动 微音学和活体动物的耳声发射。评选结果 拟议的实验与之前的实验一起由 调查人员和其他人将在计算的帮助下被解释 模特们。将使用两种类型的模型：微型机械和 巨型机械。计算模型将以物理模型为基础 可能的，并将包括机械的具体描述 Corti器、基底膜和覆盖层的特性 膜，以及毛细胞的机电转导和OHC 能动性。

The long term goal of the proposed research is to confirm that outer hair cells are responsible for electromechanical amplification in the cochlear and to clarify the underlying mechanisms of this amplification. The specific goals of the proposal are to determine which properties of the organ of Corti are responsible for the cochlear frequency map, to establish how the OHCs amplify the traveling wave, to determine how the motions of the cochlear partition is coupled to IHC stereocilia motion, and to establish how otacoustic emissions relate to the cochlea partition motion. To achieve these goals, the investigators will measure the mechanical impedance of the cellular and extracellular elements of the organ of Corti, to image the motion of the elements of the organ of Corti in response to electrical and mechanical stimulation in excised cochleas, and to simultaneously measure basilar membrane motion, cochlear microphonics, and otacoustic emissions in live animals. The results of the proposed experiments together with previous experiments by the investigators and others will be interpreted with the aid of computational models. Two types of models will be used: micromechanical and macromechanical. The computational models will be physically based as possible and will include specific descriptions of the mechanical properties of the organ of Corti, basilar membrane, and tectorial membrane, as well as hair-cell mechanoelectric transduction and OHC motility.