APPLICATION OF FLOW CYTOMETRY TO CELL BIOLOGY

实验免疫学分支流式细胞术实验室目前 支持40多名研究人员的多个研究项目。 这些研究涉及多参数定量单细胞 参数分析和基于参数的电子细胞分离 与从不同物种新鲜制备的细胞相关，和/或 组织，以及体外培养的细胞谱。基本 研究支持提供给欧洲投资银行的成员和其他 DBS内部的研究人员。目前支持的项目包括，但 不限于以下研究领域：a）体内和体外 通过T细胞表面分子的细胞内信号传导的分析; B） 分析遗传病动物的细胞过程和/或缺陷 修改; c）研究移植物抗宿主的发病机制 d）分析细胞的协调细胞表面表达; e）T细胞库生成的研究; g）分析移植抗原的表达; 参与抗原提呈过程的机制;和i） 分析了骨髓移植排斥反应的机制， 验收

The Experimental Immunology Branch flow cytometry laboratory currently supports multiple research projects for more than 40 investigators. These investigations involve multiparametric quantitative single cell analysis of, and electronic cell separation based upon, parameters associated with cells freshly prepared from different species and/or tissues, as well as a spectrum of in vitro cultured cells. Basic research support is provided to members of the EIB and to other investigators within DBS. Currently supported projects include, but are not limited to, the following areas of study: a) in vivo and in vitro analyses of intra-cellular signaling via T cell surface molecules; b) analyses of cellular processes and/or defects in animals with genetic modifications; c) studies of the pathogenesis of graft-versus host disease; d) analyses of the coordinate cell surface expression of cell adhesion molecules; e) investigations of T cell repertoire generation; g) analyses of expression of transplantation antigens; h) investigations of mechanisms involved in antigen presentation processes; and i) analyses of the mechanisms involved in marrow graft rejection versus acceptance.