Generation Malawi: A study of family, maternal and childhood mental health

马拉维一代：家庭、孕产妇和儿童心理健康研究

• 批准号: MR/S035818/1
• 负责人: Andrew McIntosh
• 金额: $ 573.24万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FS035818%2F1
• 关键词: Generation; Malawi; study; family; maternal

A lack of research training, resources, infrastructure and data in Low- and Middle-Income Countries (LMIC) greatly limits their ability to conduct studies of common mental health conditions. Nowhere is this more true than in Africa generally and in Malawi specifically, where sparse mental health care alone limits not only clinical research capacity, but also the ability to attract inward investment. In a partnership between UK and Malawian institutions, we propose to directly address this challenge by building clinical research capacity through the coordinated appointment of new researchers and research assistants, a programme of education and dissemination, and the development of a population mental health dataset focussed on an area of great unmet need - the mental heath of mothers and their children. After a period of piloting our research assessments and obtaining the necessary approvals, we will recruit 5000 mothers prior to delivery of their child from antenatal clinics in Lilongwe and Karonga districts, selected to represent urban and rural populations respectively. We will assess the mental health of mothers before and after birth, and the mental health of their spouses and other family members with a view to identifying the major risk factors for mental health disorders and mitigating variables that promote resilience. We will then examine the impact of maternal and, where possible, paternal mental health on the neurodevelopment of their offspring. In addition to creating new and highly valuable data, we will also create the bioresources needed for future genetics and 'omics based research. We believe this is essential to prevent the current imbalance in genetic research favouring rich countries of predominantly European ancestries leading to greater entrenchment of global health inequalities.As part of the proposed work, we will develop internationally competitive research capacity and datasets in Malawi, augment standard of care treatment, develop research training and the availability of affordable and effective interventions for depression and other common mental disorders, such as the "Friendship Bench" intervention. Our research will be multidisciplinary, involving experts from psychiatry, clinical psychology, nursing, reproductive and child health, and social sciences in both UK and Malawi. Throughout the project, we will carefully monitor our progress and impact on the participants and their communities. The project, if funded, will lead to a step change in mental health research capacity in Malawi, paving the way for new inward investment and the development of evidence based interventions and policies.

低收入和中等收入国家 (LMIC) 缺乏研究培训、资源、基础设施和数据，极大限制了他们对常见心理健康状况进行研究的能力。非洲尤其是马拉维尤其如此，那里精神卫生保健的匮乏不仅限制了临床研究能力，也限制了吸引外来投资的能力。在英国和马拉维机构之间的合作中，我们建议通过协调任命新的研究人员和研究助理、教育和传播计划以及开发人口心理健康数据集来直接应对这一挑战，方法是通过协调任命新的研究人员和研究助理，以及开发人口心理健康数据集，重点关注未满足的巨大需求领域——母亲及其子女的心理健康。经过一段时间的研究评估试点并获得必要的批准后，我们​​将从利隆圭和卡龙加地区的产前诊所招募 5000 名产前母亲，分别代表城市和农村人口。我们将评估母亲产前和产后的心理健康状况，以及其配偶和其他家庭成员的心理健康状况，以期找出导致心理健康障碍的主要危险因素，并缓解促进心理复原力的变量。然后，我们将研究母亲和（如果可能的话）父亲心理健康对其后代神经发育的影响。除了创建新的、高价值的数据外，我们还将创建未来遗传学和“组学研究”所需的生物资源。我们认为，这对于防止目前基因研究的不平衡现象有利于以欧洲血统为主的富裕国家，从而导致全球健康不平等现象更加严重。作为拟议工作的一部分，我们将在马拉维发展具有国际竞争力的研究能力和数据集，提高护理治疗标准，开展研究培训，并为抑郁症和其他常见精神疾病提供负担得起且有效的干预措施，例如“友谊长凳”干预措施。我们的研究将是多学科的，涉及来自英国和马拉维的精神病学、临床心理学、护理、生殖和儿童健康以及社会科学的专家。在整个项目过程中，我们将仔细监控我们的进展以及对参与者及其社区的影响。该项目如果获得资助，将导致马拉维精神卫生研究能力发生重大变化，为新的外来投资以及制定基于证据的干预措施和政策铺平道路。

项目成果

Epigenetic prediction of major depressive disorder.

• DOI: 10.1038/s41380-020-0808-3
• 发表时间: 2021-09
• 期刊: Molecular psychiatry
• 影响因子: 11
• 作者: Barbu MC;Shen X;Walker RM;Howard DM;Evans KL;Whalley HC;Porteous DJ;Morris SW;Deary IJ;Zeng Y;Marioni RE;Clarke TK;McIntosh AM
• 通讯作者: McIntosh AM

Epigenome-wide association study of global cortical volumes in generation Scotland: Scottish family health study.

• DOI: 10.1080/15592294.2021.1997404
• 发表时间: 2022-10
• 期刊: EPIGENETICS
• 影响因子: 3.7
• 作者: Barbu, Miruna Carmen;Harris, Mat;Shen, Xueyi;Aleks, Stolicyn;Green, Claire;Amador, Carmen;Walker, Rosie;Morris, Stewart;Adams, Mark;Sandu, Anca;McNeil, Christopher;Waiter, Gordon;Evans, Kathryn;Campbell, Archie;Wardlaw, Joanna;Steele, Douglas;Murray, Alison;Porteous, David;McIntosh, Andrew;Whalley, Heather
• 通讯作者: Whalley, Heather

What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.

• DOI: 10.1002/hbm.25098
• 发表时间: 2022-01
• 期刊: Human brain mapping
• 影响因子: 4.8
• 作者: Ching CRK;Hibar DP;Gurholt TP;Nunes A;Thomopoulos SI;Abé C;Agartz I;Brouwer RM;Cannon DM;de Zwarte SMC;Eyler LT;Favre P;Hajek T;Haukvik UK;Houenou J;Landén M;Lett TA;McDonald C;Nabulsi L;Patel Y;Pauling ME;Paus T;Radua J;Soeiro-de-Souza MG;Tronchin G;van Haren NEM;Vieta E;Walter H;Zeng LL;Alda M;Almeida J;Alnaes D;Alonso-Lana S;Altimus C;Bauer M;Baune BT;Bearden CE;Bellani M;Benedetti F;Berk M;Bilderbeck AC;Blumberg HP;Bøen E;Bollettini I;Del Mar Bonnin C;Brambilla P;Canales-Rodríguez EJ;Caseras X;Dandash O;Dannlowski U;Delvecchio G;Díaz-Zuluaga AM;Dima D;Duchesnay É;Elvsåshagen T;Fears SC;Frangou S;Fullerton JM;Glahn DC;Goikolea JM;Green MJ;Grotegerd D;Gruber O;Haarman BCM;Henry C;Howells FM;Ives-Deliperi V;Jansen A;Kircher TTJ;Knöchel C;Kramer B;Lafer B;López-Jaramillo C;Machado-Vieira R;MacIntosh BJ;Melloni EMT;Mitchell PB;Nenadic I;Nery F;Nugent AC;Oertel V;Ophoff RA;Ota M;Overs BJ;Pham DL;Phillips ML;Pineda-Zapata JA;Poletti S;Polosan M;Pomarol-Clotet E;Pouchon A;Quidé Y;Rive MM;Roberts G;Ruhe HG;Salvador R;Sarró S;Satterthwaite TD;Schene AH;Sim K;Soares JC;Stäblein M;Stein DJ;Tamnes CK;Thomaidis GV;Upegui CV;Veltman DJ;Wessa M;Westlye LT;Whalley HC;Wolf DH;Wu MJ;Yatham LN;Zarate CA;Thompson PM;Andreassen OA;ENIGMA Bipolar Disorder Working Group
• 通讯作者: ENIGMA Bipolar Disorder Working Group

Temporal imaginaries in accounts of parenting practices: negotiations of time, advice, and expertise

育儿实践中的时间想象：时间、建议和专业知识的谈判

• 发表时间: 2022
• 期刊: Feminism, Theory, Technoscience
• 作者: Broer, T.

Evaluating the Brain Disease Model of Addiction

评估成瘾的脑疾病模型

• DOI: 10.4324/9781003032762-30
• 发表时间: 2022
• 作者: Barnett A