CORE CENTER FOR SKELETAL INTEGRITY

骨骼完整性核心中心

• 批准号: 2848972
• 负责人: TIMOTHY M. WRIGHT
• 金额: $ 53.48万
• 依托单位: HOSPITAL FOR SPECIAL SURGERY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2004-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2848972
• 关键词: biomedical facility; bone development; bone metabolism; bone regeneration

The formation of a Core Center for Skeletal Integrity is proposed within the Research Division of the Hospital for Special Surgery (HSS). The Center will be supported by NIH-sponsored investigators at HSS working in the area of bone development and repair, investigators for whom skeletal integrity (the biological, chemical and mechanical influences that make bone such a unique tissue) is a fundamental part of the research. Key to all the research questions is the relation between composition, structure, and function that allows the skeleton to fulfill its unique role. These three important factors control skeletal integrity and their measurement and evaluation are important across all disciplines, from molecular biology to biomechanics, and at all levels of tissue organization, from molecules to the whole organ. The Core Center is intended, therefore, to provide investigators with tools for establishing chemical composition, ultra- and microstructural morphology, and tissue and whole bone mechanical properties and with training to use these tools in their research efforts. Equally important, the techniques and scientific expertise within the Center will serve as a focal point for multi-disciplinary research, thus inspiring researchers to expand their investigations beyond their own field. The Center will consist of three research cores, Analytical Microscopy, Infrared Imaging, and Mechanical Testing, organized under an Administrative Core. The Center will provide investigators with access to shared techniques (and the necessary equipment and facilities to utilize them) and with training and technical support to perform these techniques. The Center will also initially support two Pilot and Feasibility grants from young investigators and provide them with technical support and with mentors to help in their research career development. Finally, the Center will conduct an enrichment program aimed at encouraging interaction and collaboration between core users and at informing investigators as they become available within the research cores.

建议在以下范围内建立一个Skeleton完整性核心中心： 特殊外科医院（HSS）研究部。的 研究中心将得到NIH申办的HSS研究者的支持， 在骨发育和修复领域， 骨骼完整性（生物、化学和机械影响 使骨骼成为如此独特的组织）是 research.所有研究问题的关键是 组成，结构和功能，使骨骼能够实现 其独特的作用。这三个重要因素控制骨骼 诚信及其衡量和评价对所有人都很重要 从分子生物学到生物力学， 从分子到整个器官。核心 因此，中心旨在为研究者提供工具， 确定化学成分、超显微结构 形态学、组织和全骨机械性能， 培训他们在研究工作中使用这些工具。同样 重要的是，中心内的技术和科学专业知识 将作为多学科研究的焦点，因此， 鼓励研究人员将他们的研究扩展到他们自己的研究之外 领域该中心将由三个研究核心组成，分析 显微镜、红外成像和机械测试，由 行政核心。中心将为调查人员提供 分享技术（以及必要的设备和设施， 利用它们），并提供培训和技术支持， 技术.该中心最初还将支持两个试点项目， 从年轻的研究人员可行性赠款，并为他们提供 技术支持和导师，以帮助他们的研究生涯 发展最后，该中心将开展一项浓缩计划， 旨在鼓励核心用户之间的互动和协作 并在调查人员在 研究核心