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EPIDEMIOLOGIC CLINICAL GENETIC FEATURES OF SYSTEMIC SCLEROSIS IN TWINS

EPIDEMIOLOGIC CLINICAL GENETIC FEATURES OF SYSTEMIC SCLEROSIS IN TWINS
双胞胎系统性硬化症的流行病学临床遗传特征
批准号：
6219242
负责人：
TIMOTHY M. WRIGHT
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6219242
关键词：
autoantibody clinical research epidemiology family genetics gene environment interaction gene expression genetic disorder human subject systemic scleroderma twin /multiplet

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英文摘要
Systemic sclerosis (SSc) or scleroderma is an autoimmune connective tissue disease of unknown etiology. Twins provide a unique opportunity to assess the role of inherited vs. acquired genetic/environmental factors in disease development and provide the ideal controls for examining changes in gene expression at the tissue level. The aims of the proposed study are: (1) examination of a cohort of twins with SSc to determine concordance for disease; (2) confirmed pairs of twins with SSc (monozygotic and dizygotic, concordant and discordant) will be further analyzed by a detailed physical and laboratory examination (including cytogenetic analysis on peripheral blood and dermal fibroblasts, analysis of differential gene expression in dermal fibroblasts).
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