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CORE--TRANSGENES AND GENE DISRUPTION IN MURINE MODELS

CORE--TRANSGENES AND GENE DISRUPTION IN MURINE MODELS
核心——小鼠模型中的转基因和基因破坏
批准号：
6269772
负责人：
GERARD C GROSVELD
金额：
$19.16万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-06-01 至 1999-05-31
来源：
https://reporter.nih.gov/project-details/6269772
关键词：
animal breeding animal colony biomedical facility genetically modified animals laboratory mouse tissue mosaicism

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中文摘要
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英文摘要
The purpose of this core is to provide genetically modified animals, employing transgenic methodologies, for use in Projects 1-5. Mice will be obtained either via DNA injection of fertilized eggs or via injection of embryonic stem cells (ES cells) into blastocysts. The ES-cells carry targeted mutations obtained via homologous recombination. The core receives injection-ready DNA or ES-cells carrying targeted mutations from the different investigators and provides them with transgenic or chimeric mice for further breeding. In addition, the core will coordinate the injections and provide cell lines, guidance, advice and training to investigators to ensure efficient generation of the transgenic strains with a high success rate.
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CORE--TRANSGENIC AND GENE DISRUPTION LABORATORY
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