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CORE--TRANSGENIC AND GENE DISRUPTION LABORATORY

CORE--TRANSGENIC AND GENE DISRUPTION LABORATORY
核心——转基因和基因破坏实验室
批准号：
6595010
负责人：
GERARD C GROSVELD
金额：
$24.14万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
已结题
起止时间：
2002-06-01 至 2003-05-31
来源：
https://reporter.nih.gov/project-details/6595010
关键词：
animal breeding animal colony biomedical facility gene mutation genetically modified animals laboratory mouse

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中文摘要
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英文摘要
The purpose of this core is to provide genetically modified animals, employing transgenic methodologies, for use in Projects 1-4. Mice will be obtained either via DNA infection of fertilized eggs or via injection of embryonic stem cells (ES cells) into blastocysts. The ES-cells carry targeted mutations obtained via homologous recombination. The core receives injection-ready DNA or ES-cells carrying targeted mutations from the different investigators and provide them with transgenic or chimeric mice for further breeding. In addition, the core will coordinate the injections and provide cell lines, guidance, and advice to investigators to ensure efficient generation of the transgenic strains.
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CORE--TRANSGENIC/GENE KNOCKOUT SHARED RESOURCE
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