Establishing a collaboration to enable effective nutritional targeting of age-related immune decline and intestinal microbial dysbiosis

建立合作,以有效地针对与年龄相关的免疫衰退和肠道微生物失调的营养目标

基本信息

  • 批准号:
    MR/T001879/1
  • 负责人:
  • 金额:
    $ 81.93万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2019
  • 资助国家:
    英国
  • 起止时间:
    2019 至 无数据
  • 项目状态:
    已结题

项目摘要

Although people are now living longer, many older people live with significant illness. We know that lifestyle factors are important in determining this risk of ill health. These lifestyle factors include both overnutrition (too much energy-dense foods being consumed) and undernutrition (too few essential nutrients being consumed). Inflammation and a poorly functioning immune system are major contributors to age-related disease. Importantly, these immune changes also limit responses to public health measures like influenza vaccinations. New research has shown that the microbes that live inside the gut, called the intestinal microbiota, have a major influence on overall health. As we age the diversity of these microbes declines and also some microbes and their components can breach the intestinal barrier and enter the bloodstream. This is a threat to older people's immune system and contributes to risk of illness. The challenge we will address, through multidisciplinary working in this project, is the poor understanding of the links between nutrition, the intestinal microbiota and inflammation/immune decline in older adults. We plan to work in a way that will provide a step-change in the UK's national research capability in this field and through our collaboration we will develop a virtual nutritional immunology research centre that will be open to anyone who wishes to participate in this research area. We will provide strong leadership to the research community through:a) hosting a series of three workshops to discuss and define key methodological issues in the area; b) the development and distribution of standard operating procedures to carry out research studying the interactions of nutrition, the immune system and the intestinal microbiota; c) the publication of three academic papers outlining best practice for research in the areas of human nutrition and human nutrition clinical trials, nutritional immunology and the intestinal microbiome. In addition, we will conduct a feasibility study to test our ability to recruit and carry out interventions in older populations with high levels of completion and compliance, to test our standard operating procedures and refine them if necessary, to process and exchange samples, to integrate and understand our findings, and to generate the robust pilot information that is needed to design more definitive trials of nutritional approaches for targeting the intestinal microbiota, inflammation and the immune system in older people. The feasibility study will involve giving participants vitamin D and probiotics, alone and together for a period of 3 months. There is a good rationale for testing both vitamin D and probiotics, because older people often have low vitamin D status and altered intestinal microbes both of which can affect inflammation and the ability of the immune system to function properly. Key outcomes of the feasibility study will be to understand the effects and impact on inflammation, immune function and intestinal microbiota diversity. We will use mathematical modelling to integrate the resulting data systematically aiding the characterisation, and enhancing the understanding, of the complex interactions among these outcomes in the contexts of older people and our interventions. We will make our samples and data available to other researchers. Further, we will plan future trials and develop a strategy to ensure sustainability of our collaboration. To broaden our influence we will link with the wider academic community, the public, industry, non-governmental organisations, and existing European projects in relevant areas.
尽管人们现在活得更长了,但许多老年人患有严重的疾病。我们知道,生活方式因素在决定这种不健康的风险方面很重要。这些生活方式因素既包括营养过剩(消耗了太多高能量食物),也包括营养不足(消耗的基本营养素太少)。炎症和功能低下的免疫系统是与年龄相关的疾病的主要因素。重要的是,这些免疫变化也限制了对流感疫苗等公共卫生措施的反应。新的研究表明,生活在肠道内的微生物,即肠道微生物区系,对整体健康有重大影响。随着我们年龄的增长,这些微生物的多样性会下降,一些微生物及其成分也会突破肠道屏障,进入血液。这对老年人的免疫系统构成了威胁,并增加了患病的风险。我们将通过这个项目的多学科合作来解决的挑战是,对老年人营养、肠道微生物区系和炎症/免疫功能下降之间的联系缺乏了解。我们计划以一种将为英国在这一领域的国家研究能力带来阶段性变化的方式开展工作,通过我们的合作,我们将开发一个虚拟的营养免疫学研究中心,向希望参与这一研究领域的任何人开放。我们将通过以下方式向研究界提供强有力的领导:a)主办一系列三次研讨会,讨论和确定该领域的关键方法学问题;b)制定和分发标准作业程序,以开展研究营养、免疫系统和肠道微生物区系相互作用的研究;c)发表三篇学术论文,概述人类营养和人类营养临床试验、营养免疫学和肠道微生物群领域研究的最佳实践。此外,我们将进行一项可行性研究,以测试我们招募并在高完成率和遵从性的老年人口中进行干预的能力,测试我们的标准操作程序并在必要时对其进行改进,处理和交换样本,整合和理解我们的研究结果,并产生必要的强大试点信息,以设计针对老年人肠道微生物区系、炎症和免疫系统的更明确的营养方法试验。可行性研究将包括给参与者单独和一起服用维生素D和益生菌,为期3个月。同时测试维生素D和益生菌是有充分理由的,因为老年人的维生素D水平通常较低,肠道微生物也会发生变化,这两者都会影响炎症和免疫系统正常运作的能力。可行性研究的主要结果将是了解对炎症、免疫功能和肠道微生物群多样性的影响和影响。我们将使用数学建模来系统地整合所产生的数据,以帮助描述和加强对老年人和我们的干预措施背景下这些结果之间复杂相互作用的理解。我们将向其他研究人员提供我们的样本和数据。此外,我们将规划未来的试验并制定战略,以确保我们合作的可持续性。为了扩大我们的影响力,我们将与更广泛的学术界、公众、行业、非政府组织和相关领域的现有欧洲项目联系起来。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Nutrition and immunity: lessons from coronavirus disease-2019.
营养和免疫:2019 年冠状病毒病的教训。
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Philip Calder其他文献

Gene Polymorphism−Fish Oil Interactions in the Context of Cardiovascular Risk
  • DOI:
    10.1016/j.jacl.2011.03.076
  • 发表时间:
    2011-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Jaqueline Madden;Christine Williams;Philip Calder;Elizabeth Miles;John Mathers;George Leitz;Heather Cordell;Anne Marie Minihane
  • 通讯作者:
    Anne Marie Minihane
A review of the biologic and pharmacological role of docosapentaenoic acid [version 1; peer review: 2 approved with reservations]
二十二碳五烯酸的生物学和药理学作用综述[第 1 版;
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    P. G. Yazdi;Philip Calder;Bruce Bistrian
  • 通讯作者:
    Bruce Bistrian

Philip Calder的其他文献

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{{ truncateString('Philip Calder', 18)}}的其他基金

BBSRC IAA University of Southampton
BBSRC IAA 南安普顿大学
  • 批准号:
    BB/X51231X/1
  • 财政年份:
    2023
  • 资助金额:
    $ 81.93万
  • 项目类别:
    Research Grant
Understanding how food and beverages deliver improved nutrition across the lifecourse
了解食品和饮料如何在整个生命周期提供改善的营养
  • 批准号:
    BB/X010821/1
  • 财政年份:
    2022
  • 资助金额:
    $ 81.93万
  • 项目类别:
    Research Grant

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