A Novel High Intensity Short Interval Dance Intervention for Non Communicable Disease(NCD) Prevention in Asian Indian Adolescent Girls-THANDAV

一种新的高强度短间隔舞蹈干预亚洲印度青少年女孩非传染性疾病（NCD）预防- THANDAV -一项试点研究。这项拟议的发展赠款议定书将在印度进行，为期18个月。我们将测试一种个性化的锻炼和教育干预措施，在数字技术的帮助下，提供这种新颖的“THANDAV”（为青少年提供HIIT和舞蹈，以战胜非传染性疾病）干预措施。主要的研究问题将是-文化上适当的高强度短时间（10分钟）舞蹈干预能否成为10- 17岁亚洲印度女孩的可持续运动，以改善她们的身体健康和预防非传染性疾病？非传染性疾病造成的负担已达到爆炸性的比例，增幅最大的是印度等中低收入国家。印度的运动水平非常低，女性比男性更少活跃。青少年和青年体育活动的益处已得到充分证实，大多数全球指南建议每天至少进行60分钟的中度至剧烈体育活动。有证据表明，青春期是身体活动下降最快的时期，因此使我们所选择的队列成为糖尿病和其他非传染性疾病的高风险年龄组。印度2型糖尿病的发病年龄为25- 34岁。因此，必须努力促进青少年和青年的体育活动，女性锻炼的障碍包括时间限制和"文化上不接受“的锻炼。舞蹈是印度社会和文化上接受的活动形式。我们假设，THANDAV干预的持续时间短和有趣的元素，加上舞蹈的文化和社会可接受性，将有助于这种干预的长期可持续性，这对NCD预防至关重要。我们的目的是调查的发展，可行性，可接受的干预和改善青少年的身体活动和健身水平。因此，主要结果将是增加身体活动（以步数衡量），从而改善青春期女孩的健康水平（以心率衡量）。在通过这项试点研究评估了干预的方法和影响后，我们计划申请全额试验资助，其中我们将以随机对照试验模式，通过即兴数字设计评估THANDAV干预对有形代谢健康结果的可持续影响。全部试验补助金的结果将是代谢参数，包括体重、体脂、血压、葡萄糖、血脂、胰岛素沿着重要的结果指标，包括可持续性和可扩展性。自2017年以来，MDRF一直与苏格兰（英国）邓迪大学（UoD）的多学科研究人员合作，作为为期4年的NIHR全球糖尿病结局研究全球健康研究部门的一部分。印度-苏格兰糖尿病精准医学合作伙伴关系（INSPIRED）项目旨在提高对糖尿病及其并发症高负担背后的遗传，生活方式和环境因素的理解。THANDAV提案是现有合作的延伸，Colin Palmer博士是苏格兰（英国）邓迪大学（UoD）的共同研究者。

A Novel High Intensity Short Interval Dance Intervention for Non Communicable Disease (NCD) Prevention in Asian Indian Adolescent Girls - THANDAV - a pilot study. This proposed developmental grant protocol will take place in India with a duration of 18 months. We will test a personalized exercise and education intervention, aided by digital technology to deliver this novel 'THANDAV' (Taking HIIT And Dance to Adolescents for Victory over NCDs) intervention. The principal research question will be - Can a culturally appropriate high intensity short duration (10 min) dance intervention become sustainable exercise in Asian Indian girls aged 10- 17 years to improve their physical fitness and prevent NCDs? The burden due to NCDs has reached explosive proportions with the largest increases happening in low and middle-income countries like India. Exercises levels are abysmally low in India with women being less active than men. The benefits of physical activity in adolescents and youth are well established, with most global guidelines recommending at least 60 minutes of moderate to vigorous physical activity per day. Evidence suggests that adolescence is the time of steepest decline in physical activity, thus making our chosen cohort high-risk age group for diabetes and other non-communicable diseases. The age of onset of type 2 diabetes in India is in the age group of 25- 34 years. Hence, efforts to promote physical activity among adolescents and youth are essential.The barriers to exercising in females include time constraints and exercise not being 'culturally acceptable'. Dance is a socially and culturally accepted form of activity in India. We hypothesize that the short duration and fun element of the THANDAV intervention, coupled with the cultural and social acceptability of dance, will aid the long-term sustainability of such an intervention, which is vital for NCD prevention. We aim to investigate the development, feasibility, acceptability of the intervention and resulting improvements in physical activity and fitness levels in adolescents. The primary outcome will thus be increases in physical activity as measured by step count leading to improvement in fitness levels as measured by heart rate of adolescent girls. After assessing the methodology and impact of the intervention through this pilot study, we plan to apply for the full trial grant wherein we will evaluate the sustainable impact of the THANDAV intervention with an improvised digital design on tangible metabolic health outcomes in a randomized controlled trial mode. The outcomes in the full trial grant will be metabolic parameters including weight, body fat, blood pressure, glucose, lipids, insulin along with important outcome measures including sustainability and scalability. MDRF has been collaborating with multi-disciplinary investigators from the University of Dundee (UoD), Scotland (UK) since 2017 as part of a 4-year NIHR Global Heath Research Unit on Global Diabetes Outcomes Research. The India-Scotland Partnership for Precision Medicine in Diabetes (INSPIRED) project aims to improve the understanding of genetic, lifestyle and environmental factors underlying the high burden of diabetes and its complications. The THANDAV proposal is an extension of this existing collaboration with Dr. Colin Palmer being the Co-Investigator from University of Dundee (UoD), Scotland (UK).