A Novel High Intensity Short Interval Dance Intervention for Non Communicable Disease(NCD) Prevention in Asian Indian Adolescent Girls-THANDAV

一种预防亚洲印度少女非传染性疾病 (NCD) 的新型高强度短间隔舞蹈干预措施-THANDAV

• 批准号: MR/T003626/1
• 负责人: RM Anjana
• 金额: $ 18.88万
• 依托单位: Madras Diabetes Research Foundation
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FT003626%2F1
• 关键词: Novel; Intensity; Short; Interval; Dance

A Novel High Intensity Short Interval Dance Intervention for Non Communicable Disease (NCD) Prevention in Asian Indian Adolescent Girls - THANDAV - a pilot study. This proposed developmental grant protocol will take place in India with a duration of 18 months. We will test a personalized exercise and education intervention, aided by digital technology to deliver this novel 'THANDAV' (Taking HIIT And Dance to Adolescents for Victory over NCDs) intervention. The principal research question will be - Can a culturally appropriate high intensity short duration (10 min) dance intervention become sustainable exercise in Asian Indian girls aged 10- 17 years to improve their physical fitness and prevent NCDs? The burden due to NCDs has reached explosive proportions with the largest increases happening in low and middle-income countries like India. Exercises levels are abysmally low in India with women being less active than men. The benefits of physical activity in adolescents and youth are well established, with most global guidelines recommending at least 60 minutes of moderate to vigorous physical activity per day. Evidence suggests that adolescence is the time of steepest decline in physical activity, thus making our chosen cohort high-risk age group for diabetes and other non-communicable diseases. The age of onset of type 2 diabetes in India is in the age group of 25- 34 years. Hence, efforts to promote physical activity among adolescents and youth are essential.The barriers to exercising in females include time constraints and exercise not being 'culturally acceptable'. Dance is a socially and culturally accepted form of activity in India. We hypothesize that the short duration and fun element of the THANDAV intervention, coupled with the cultural and social acceptability of dance, will aid the long-term sustainability of such an intervention, which is vital for NCD prevention. We aim to investigate the development, feasibility, acceptability of the intervention and resulting improvements in physical activity and fitness levels in adolescents. The primary outcome will thus be increases in physical activity as measured by step count leading to improvement in fitness levels as measured by heart rate of adolescent girls. After assessing the methodology and impact of the intervention through this pilot study, we plan to apply for the full trial grant wherein we will evaluate the sustainable impact of the THANDAV intervention with an improvised digital design on tangible metabolic health outcomes in a randomized controlled trial mode. The outcomes in the full trial grant will be metabolic parameters including weight, body fat, blood pressure, glucose, lipids, insulin along with important outcome measures including sustainability and scalability. MDRF has been collaborating with multi-disciplinary investigators from the University of Dundee (UoD), Scotland (UK) since 2017 as part of a 4-year NIHR Global Heath Research Unit on Global Diabetes Outcomes Research. The India-Scotland Partnership for Precision Medicine in Diabetes (INSPIRED) project aims to improve the understanding of genetic, lifestyle and environmental factors underlying the high burden of diabetes and its complications. The THANDAV proposal is an extension of this existing collaboration with Dr. Colin Palmer being the Co-Investigator from University of Dundee (UoD), Scotland (UK).

用于预防亚裔印度少女非传染性疾病 (NCD) 的新型高强度短间隔舞蹈干预措施 - THANDAV - 一项试点研究。拟议的发展拨款协议将在印度实施，为期 18 个月。我们将测试个性化的锻炼和教育干预措施，并在数字技术的帮助下提供这种新颖的“THANDAV”（为青少年进行HIIT和舞蹈以战胜非传染性疾病）干预措施。主要研究问题是：文化上适当的高强度短时（10 分钟）舞蹈干预能否成为 10-17 岁亚裔印度女孩的可持续运动，以改善她们的身体健康并预防非传染性疾病？非传染性疾病造成的负担已达到爆炸性程度，其中印度等低收入和中等收入国家的增幅最大。印度的运动水平极低，女性的运动量低于男性。体育活动对青少年的好处已得到充分证实，大多数全球指南建议每天至少进行 60 分钟的中度至剧烈体育活动。有证据表明，青春期是体力活动下降最严重的时期，因此我们选择的队列成为糖尿病和其他非传染性疾病的高风险年龄组。印度2型糖尿病的发病年龄为25-34岁。因此，努力促进青少年和年轻人的身体活动至关重要。女性锻炼的障碍包括时间限制和锻炼在“文化上不可接受”。在印度，舞蹈是一种被社会和文化接受的活动形式。我们假设 THANDAV 干预措施的持续时间短且有趣，加上舞蹈的文化和社会可接受性，将有助于这种干预措施的长期可持续性，这对于预防非传染性疾病至关重要。我们的目的是调查干预措施的发展、可行性、可接受性以及由此产生的青少年身体活动和健康水平的改善。因此，主要结果将是增加以步数衡量的体力活动，从而改善以青春期女孩的心率衡量的健康水平。通过这项试点研究评估干预措施的方法和影响后，我们计划申请全额试验拨款，其中我们将通过随机对照试验模式，通过临时数字设计对有形代谢健康结果评估 THANDAV 干预措施的可持续影响。全额试验资助的结果将是代谢参数，包括体重、体脂、血压、葡萄糖、血脂、胰岛素，以及包括可持续性和可扩展性在内的重要结果指标。自 2017 年以来，MDRF 一直与苏格兰（英国）邓迪大学 (UoD) 的多学科研究人员合作，作为为期 4 年的 NIHR 全球健康研究单位全球糖尿病结果研究的一部分。印度-苏格兰糖尿病精准医学合作伙伴关系 (INSPIRED) 项目旨在提高对糖尿病及其并发症高负担背后的遗传、生活方式和环境因素的了解。 THANDAV 提案是与来自苏格兰（英国）邓迪大学 (UoD) 联合研究员 Colin Palmer 博士现有合作的延伸。