A Novel High Intensity Short Interval Dance Intervention for Non Communicable Disease(NCD) Prevention in Asian Indian Adolescent Girls-THANDAV

一种新的高强度短间隔舞蹈干预对亚洲印度少女非传染性疾病（NCD）预防- THANDAV -一项试点研究。这项拟议的发展赠款协议将在印度实施，为期18个月。我们将测试一种个性化的运动和教育干预，在数字技术的帮助下，提供这种新颖的“THANDAV”（将HIIT和舞蹈带给青少年，以战胜非传染性疾病）干预。主要研究问题将是-文化上合适的高强度短时间（10分钟）舞蹈干预能否成为10- 17岁亚洲印度女孩的可持续锻炼，以提高她们的身体素质和预防非传染性疾病？非传染性疾病造成的负担已达到爆炸性的程度，其中印度等低收入和中等收入国家的增幅最大。印度的运动水平极低，女性比男性更不活跃。身体活动对青少年和青年的益处是众所周知的，大多数全球指南建议每天至少进行60分钟的中度至剧烈身体活动。有证据表明，青春期是身体活动减少最严重的时期，因此我们选择的队列是糖尿病和其他非传染性疾病的高危年龄组。印度2型糖尿病的发病年龄在25- 34岁之间。因此，努力促进青少年和青年的身体活动至关重要。女性运动的障碍包括时间限制和运动不被“文化接受”。在印度，舞蹈是一种被社会和文化接受的活动形式。我们假设THANDAV干预的短时间和乐趣元素，加上舞蹈的文化和社会可接受性，将有助于这种干预的长期可持续性，这对非传染性疾病的预防至关重要。我们的目的是调查干预的发展、可行性和可接受性，并由此改善青少年的身体活动和健康水平。因此，主要结果将是以步数衡量的体力活动增加，从而导致以心率衡量的青春期女孩健康水平的改善。在通过该试点研究评估了干预的方法和影响后，我们计划申请全额试验拨款，其中我们将在随机对照试验模式下评估THANDAV干预的可持续影响，该干预采用临时数字设计，对有形代谢健康结果产生影响。全部试验拨款的结果将包括代谢参数，包括体重、体脂、血压、葡萄糖、脂质、胰岛素，以及包括可持续性和可扩展性在内的重要结果测量。自2017年以来，MDRF一直与苏格兰（英国）邓迪大学（UoD）的多学科研究人员合作，作为为期4年的NIHR全球健康研究小组全球糖尿病结局研究的一部分。印度-苏格兰糖尿病精准医疗伙伴关系（INSPIRED）项目旨在提高对糖尿病及其并发症高负担背后的遗传、生活方式和环境因素的理解。THANDAV提案是与苏格兰（英国）邓迪大学（UoD）的Colin Palmer博士合作的现有合作的延伸。

A Novel High Intensity Short Interval Dance Intervention for Non Communicable Disease (NCD) Prevention in Asian Indian Adolescent Girls - THANDAV - a pilot study. This proposed developmental grant protocol will take place in India with a duration of 18 months. We will test a personalized exercise and education intervention, aided by digital technology to deliver this novel 'THANDAV' (Taking HIIT And Dance to Adolescents for Victory over NCDs) intervention. The principal research question will be - Can a culturally appropriate high intensity short duration (10 min) dance intervention become sustainable exercise in Asian Indian girls aged 10- 17 years to improve their physical fitness and prevent NCDs? The burden due to NCDs has reached explosive proportions with the largest increases happening in low and middle-income countries like India. Exercises levels are abysmally low in India with women being less active than men. The benefits of physical activity in adolescents and youth are well established, with most global guidelines recommending at least 60 minutes of moderate to vigorous physical activity per day. Evidence suggests that adolescence is the time of steepest decline in physical activity, thus making our chosen cohort high-risk age group for diabetes and other non-communicable diseases. The age of onset of type 2 diabetes in India is in the age group of 25- 34 years. Hence, efforts to promote physical activity among adolescents and youth are essential.The barriers to exercising in females include time constraints and exercise not being 'culturally acceptable'. Dance is a socially and culturally accepted form of activity in India. We hypothesize that the short duration and fun element of the THANDAV intervention, coupled with the cultural and social acceptability of dance, will aid the long-term sustainability of such an intervention, which is vital for NCD prevention. We aim to investigate the development, feasibility, acceptability of the intervention and resulting improvements in physical activity and fitness levels in adolescents. The primary outcome will thus be increases in physical activity as measured by step count leading to improvement in fitness levels as measured by heart rate of adolescent girls. After assessing the methodology and impact of the intervention through this pilot study, we plan to apply for the full trial grant wherein we will evaluate the sustainable impact of the THANDAV intervention with an improvised digital design on tangible metabolic health outcomes in a randomized controlled trial mode. The outcomes in the full trial grant will be metabolic parameters including weight, body fat, blood pressure, glucose, lipids, insulin along with important outcome measures including sustainability and scalability. MDRF has been collaborating with multi-disciplinary investigators from the University of Dundee (UoD), Scotland (UK) since 2017 as part of a 4-year NIHR Global Heath Research Unit on Global Diabetes Outcomes Research. The India-Scotland Partnership for Precision Medicine in Diabetes (INSPIRED) project aims to improve the understanding of genetic, lifestyle and environmental factors underlying the high burden of diabetes and its complications. The THANDAV proposal is an extension of this existing collaboration with Dr. Colin Palmer being the Co-Investigator from University of Dundee (UoD), Scotland (UK).