Dietary patterns, microbiome, metabolome and cardiovascular disease risk in transitioning India

印度转型期的饮食模式、微生物组、代谢组和心血管疾病风险

基本信息

  • 批准号:
    MR/T008504/1
  • 负责人:
  • 金额:
    $ 6.29万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2019
  • 资助国家:
    英国
  • 起止时间:
    2019 至 无数据
  • 项目状态:
    已结题

项目摘要

A growing number of people living in India are suffering from heart disease. Many researchers think that this is because of changes in diet (from traditional diets rich in cereals to western diets rich in sugars, fats and meat products) that occur when countries develop economically. The dietary changes in India appear to be different from other developing countries due to a strong cultural preference for vegetarian food. Therefore, our goal is to understand how dietary changes in India may be influencing the risk of heart disease. We are particularly interested in the role of bacteria that usually live harmlessly in our gut, as new research suggests their involvement in many health conditions.For nearly two decades, we have been conducting health-related research in 29 villages on the edge of Hyderabad city in South India. Over the past decade, these villages have undergone rapid uneven development providing a unique opportunity to understand the health effects of dietary changes. In 2010-12, we collected data on diet and heart health of ~7,000 individuals from this community. We now plan to collect similar data on these individuals, including their blood and stool samples. We will use state-of-the-art technologies to identify the patterns of small molecules in the blood (i.e. metabolomics) and bacteria in the gut (i.e. microbiome). We will then analyse the data to understand how dietary patterns and gut bacteria may influence the risk of heart disease at a deeper (molecular) level. Findings from this research will inform dietary guidelines and food policy in India, and ultimately lead to a reduction in economic loss to the country from heart disease.
越来越多的印度人患有心脏病。许多研究人员认为,这是因为当国家经济发展时,饮食发生了变化(从富含谷物的传统饮食到富含糖、脂肪和肉类产品的西方饮食)。印度的饮食变化似乎与其他发展中国家不同,这是由于对素食的强烈文化偏好。因此,我们的目标是了解印度的饮食变化如何影响心脏病的风险。我们对通常无害地生活在我们肠道中的细菌的作用特别感兴趣,因为新的研究表明它们与许多健康状况有关。近二十年来,我们一直在印度南部海得拉巴市边缘的29个村庄进行健康相关研究。在过去十年中,这些村庄经历了快速的不平衡发展,为了解饮食变化对健康的影响提供了独特的机会。在2010-12年,我们收集了来自该社区的约7,000人的饮食和心脏健康数据。我们现在计划收集这些人的类似数据,包括他们的血液和粪便样本。我们将使用最先进的技术来识别血液中的小分子(即代谢组学)和肠道中的细菌(即微生物组)的模式。然后,我们将分析数据,以了解饮食模式和肠道细菌如何在更深层次(分子)水平上影响心脏病的风险。这项研究的结果将为印度的饮食指南和食品政策提供信息,并最终导致减少心脏病对该国的经济损失。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Sanjay Kinra其他文献

[Body image is associated with anthropometric status in adolescents, but not with lifestyle].
[身体形象与青少年的人体测量状况相关,但与生活方式无关]。
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Lorena Rocha Andrade;Mônica Leila Portela de Santana;Priscila Ribas Farias Costa;A. M. Assis;Sanjay Kinra
  • 通讯作者:
    Sanjay Kinra
35. Does a Motivational Lifestyle Intervention (the Healthy Eating and Lifestyle Programme (HELP)) Work for Obese Young People
  • DOI:
    10.1016/j.jadohealth.2014.10.038
  • 发表时间:
    2015-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Deborah Christie;Lee D. Hudson;Sanjay Kinra;Irwin Nazareth;Rebecca Holt;Anthony Kessel;Ian Wong;Tim Cole;Steve Morris;Silvia Costa;Russell M. Viner
  • 通讯作者:
    Russell M. Viner
Erratum to: Interaction between FTO gene variants and lifestyle factors on metabolic traits in an Asian Indian population
  • DOI:
    10.1186/s12986-016-0100-3
  • 发表时间:
    2016-06-13
  • 期刊:
  • 影响因子:
    4.100
  • 作者:
    Karani S. Vimaleswaran;Dhanasekaran Bodhini;N. Lakshmipriya;K. Ramya;R. Mohan Anjana;Vasudevan Sudha;Julie A. Lovegrove;Sanjay Kinra;Viswanathan Mohan;Venkatesan Radha
  • 通讯作者:
    Venkatesan Radha
Effect of Yoga-Based Cardiac Rehabilitation Program on Endothelial Function, Oxidative Stress, and Inflammatory Markers in Acute Myocardial Infarction: A Randomized Controlled Trial
基于瑜伽的心脏康复计划对急性心肌梗死内皮功能、氧化应激和炎症标志物的影响:随机对照试验
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    1.6
  • 作者:
    Satish G Patil;Edmin Christa Sobitharaj;A. Chandrasekaran;Shankar S. Patil;Kalpana Singh;Ruby Gupta;Kishore K. Deepak;A. Jaryal;Dinu S. Chandran;Sanjay Kinra;Ambuj Roy;Dorairaj Prabhakaran
  • 通讯作者:
    Dorairaj Prabhakaran
Development of a tool to estimate sugar and caloric contents in alcoholic beverages for a diabetes self-management program in Thailand.
  • DOI:
    10.1016/j.heliyon.2023.e21162
  • 发表时间:
    2023-11
  • 期刊:
  • 影响因子:
    4
  • 作者:
    Thin Nyein Nyein Aung;Kanittha Thaikla;Nutchar Wiwatkunupakarn;Chanchanok Aramrat;Kanokporn Pinyopornpanish;Wichuda Jiraporncharoen;Orawan Quansri;Iliatha Papachristou Nadal;Sanjay Kinra;Chaisiri Angkurawaranon
  • 通讯作者:
    Chaisiri Angkurawaranon

Sanjay Kinra的其他文献

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{{ truncateString('Sanjay Kinra', 18)}}的其他基金

Explaining the differential severity of COVID-19 between Indians in India and the UK
解释印度和英国印度人之间的 COVID-19 严重程度差异
  • 批准号:
    MR/V040235/1
  • 财政年份:
    2021
  • 资助金额:
    $ 6.29万
  • 项目类别:
    Research Grant
Dietary ompatterns, microbiome, metabole and cardiovascular disease risk in transitioning India
印度转型期的饮食模式、微生物组、代谢和心血管疾病风险
  • 批准号:
    MR/V001221/1
  • 财政年份:
    2021
  • 资助金额:
    $ 6.29万
  • 项目类别:
    Research Grant
Extending an inter-generational cohort to develop a multimorbidity research platform in rural and urbanising India
扩大代际队列,在印度农村和城市化地区开发多病研究平台
  • 批准号:
    MC_PC_MR/T038292/1
  • 财政年份:
    2020
  • 资助金额:
    $ 6.29万
  • 项目类别:
    Research Grant
A scalable solution for supporting informal stroke caregivers in Malaysia: systematic development and feasibility study
支持马来西亚非正式中风护理人员的可扩展解决方案:系统开发和可行性研究
  • 批准号:
    MR/T018968/1
  • 财政年份:
    2019
  • 资助金额:
    $ 6.29万
  • 项目类别:
    Research Grant
A scalable solution for delivery of Diabetes Self-Management Education in Thailand
用于在泰国提供糖尿病自我管理教育的可扩展解决方案
  • 批准号:
    MR/R020876/1
  • 财政年份:
    2018
  • 资助金额:
    $ 6.29万
  • 项目类别:
    Research Grant
Gestational diabetes in Uganda and India: Design and Evaluation of Educational Films for improving Screening and Self-management (GUIDES)
乌干达和印度的妊娠糖尿病:用于改善筛查和自我管理的教育电影的设计和评估(指南)
  • 批准号:
    MR/R021392/1
  • 财政年份:
    2018
  • 资助金额:
    $ 6.29万
  • 项目类别:
    Research Grant
Development and evaluation of a yoga-based cardiac rehabilitation programme (Yoga-CaRe) for secondary prevention of myocardial infarction
用于心肌梗死二级预防的基于瑜伽的心脏康复计划(Yoga-CaRe)的开发和评估
  • 批准号:
    MR/J000175/1
  • 财政年份:
    2013
  • 资助金额:
    $ 6.29万
  • 项目类别:
    Research Grant

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  • 批准号:
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