MOLECULAR PEDIATRICS AND CHILD HEALTH

山顶儿童健康研究中心的总体目标 西奈医学院将为选定的年轻儿科医生 拥有智力和核心实验室设施的调查人员 发展以分子儿科为主题的基础科学研究项目 这将有助于他们作为独立的职业发展 医生/科学家。在首席调查员的指导下 和项目总监，一组来自 儿科、生物化学、细胞生物学和解剖学系 遗传学、医学、微生物学、分子生物学、神经生物学和 生理学和生物物理学将提供基础科学研究 年轻儿科研究人员的机会与此相关 为儿科医学和未来自主提供示范体系 研究项目。其中包括1)分子方面的研究机会 溶酶体贮藏疾病的遗传学，2)逆转录病毒介导的基因 镰状细胞病和β-地中海贫血的治疗，3)组织特异性 珠蛋白和血红素的基因调控及遗传性研究 4)子宫干细胞移植和基因转移 Glanzmann‘s血小板减少症粘膜中的造血干细胞 人B细胞的免疫调节和淋巴因子调节 分化，6)流感病毒的基因操作，用作 疫苗和载体，9)转基因小鼠在人类遗传学中的应用，11) 过氧化物体组装和过氧化物体病的分子研究，12) 开发新疫苗的分子途径，分子 生长发育中的胶原蛋白遗传学，14)神经内分泌学 应激和生殖作为研究发展的模式系统， 以及15)在动物模型系统中发展基因治疗策略。 共享的核心实验室将提供寡核苷酸合成， 测序和组织培养系统，以及建立基因敲除 为年轻研究人员的努力提供便利的老鼠模型。高- 将为该计划招聘高质量、新培训的儿科医生 从地方和国家池中选出，将由顾问 委员会审议阶段。年轻的儿科研究员和老牌儿科医生 调查人员将参加周刊俱乐部和月刊俱乐部 研讨会和一年一度的研究研讨会。这个卓越的中心将 提供智力环境和核心实验室设施 促进年轻儿科研究员的发展，他们将成为 独立并将他们的分子专业知识应用于当前和未来 儿科医学中的问题。

The overall objective of the Child Health Research Center at the Mount Sinai School of Medicine is to provide selected Young Pediatric Investigators with an intellectual and core laboratory facilities to develop basic science research programs with a molecular pediatrics theme that will facilitate their career development as independent physician/scientists. Under the direction of the Principal Investigator and the Program Director, a group of Established Investigators from the Departments of Pediatrics, Biochemistry, Cell Biology and Anatomy, Human Genetics, Medicine, Microbiology, Molecular Biology, Neurobiology, and Physiology and Biophysics will provide basic science research opportunities for the Young Pediatric Investigators which have relevance to Pediatric medicine and provide model systems for future independent research projects. Among these are research opportunities in 1) molecular genetics of lysosomal storage diseases, 2) retroviral-mediated gene therapy of sickle cell disease and beta-thalassemia, 3) tissue specific gene regulation of globin and heme, and studies of the inherited porphyrias, 4) in utero stem cell transplantation and gene transfer into hematopoietic stem cells in Glanzmann's thrombasthenia, 5) mucosal immunoregulation and lymphokine regulation of human B cell differentiation, 6) genetic manipulation of influenza viruses for use as vaccines and vectors, 9) use of transgenic mice in human genetics, 11) molecular studies of peroxisomal assembly and peroxisomal disorders, 12) molecular approaches to the development of new vaccines, 13) molecular genetics of collagen in growth and development, 14) the neuroendocrinology of stress and reproduction as a model system for the study of development, and 15) development of gene therapy strategies in animal model systems. Shared core laboratories will provide oligonucleotides synthesis, sequencing and tissue culture systems, and the establishment of knock-out mouse models to facilitate the efforts of young investigators. High- quality , newly trained pediatricians will be recruited for this program from local and national pools and will be selected by an Advisory Committee. The Young Pediatric Investigators and the Established Investigators will participate in weekly Journal Club, and in monthly seminar, and an annual Research Symposium. This center of excellence will provide the intellectual environment and core laboratory facilities to enhance the development of Young Pediatric Investigators who will become independent and apply their molecular expertise to current and future problems in pediatric medicine.