Molecular & Developmental Biology in Pediatric Research

西奈山学校的儿童健康研究职业发展奖（CHRCDA）计划 医学的目的是提供指导，密集的基础研究经验，为期2-3年 为儿科医生在生物医学研究中的生产和独立职业做好准备， 学术儿科学该提案的主题是“儿科的分子和发育生物学”， 与儿童时期最常见的疾病有着独特的相关性。它包括正常的发育 生物学以及胎儿和儿童对个体发育过程中发生的伤害的适应。的 该计划的多学科性质-从建立科学家的经验， 儿科、人类遗传学、内科、分子、细胞和发育学系 生物学，免疫生物学，药理学和生物化学，生理学和生物物理学-有 从共同的兴趣，频繁的互动，儿科科学家过去的培训和几个领域发展而来， 教师正在进行的合作研究。该计划将提供严格和灵活的基本 通过collegia为年轻的儿科科学家提供研究经验！与中心教师的互动，通过 启动资金由新项目开发奖提供，并通过该计划的教育 核心项目执行委员会对新项目开发学者的选择将高度重视 竞争力，只有那些具有特殊证书或潜力的个人才会被接受。 方案的执行委员会。一项新的战略，以招募代表性不足的少数民族的计划将 实行将为每个学者准备一份职业规划，考虑具体的长期和短期- 长期研究的职业目标和能力，这将有助于发展作为一个独立的 调查员该计划在儿科系和基础科学的教师的实验室 各部门将作为儿科研究人员发展的场所。CHRCDA计划将利用 西奈山医学院的共享核心实验室，如最先进的方法， 细胞和整个动物成像，用于生产转基因和基因敲除小鼠模型，以及用于高 通量基因筛选和基因表达谱分析。所有CHRCDA学者将参加教学 旨在加强其辅导计划的会议。定期研究研讨会和定期实验室 研讨会还将促进年轻研究人员和项目教师之间的互动。总体看 该计划通过实验室设施和教师的集中化，现有的相互作用， 研究机构内的研究计划，许多核心实验室资源，这是现成的， 研究人员，和高素质的申请人的招聘基地已经吸引了卓越的 西奈山的临床部门和基础科学。

The Child Health Research Career Development Award (CHRCDA) Program at the Mount Sinai School of Medicine is designed to provide mentored, intensive basic research experience for a period of 2-3 years necessary to prepare pediatricians for productive and independent careers in biomedical research and academic pediatrics. The theme of this proposal, "Molecular and Developmental Biology in Pediatrics," has unique relevance to the most common disorders seen in childhood. It encompasses normal developmental biology as well as adaptation of the fetus and child to insults occurring during ontogenesis. The multidisciplinary nature of the program - drawing from the experience of established scientists inthe Department of Pediatrics, Human Genetics, Internal Medicine, Molecular, Cellular and Developmental Biology, Immunobiology, Pharmacology and Biological Chemistry, and Physiology and Biophysics - has evolved from common interests, frequent interactions, past training of pediatric scientists, and several areas of ongoing collaborative research of the faculty. The program will provide rigorous and flexible basic research experience for young pediatric scientists through collegia! interaction with Center faculty, through startup funding as provided by new project development awards, and through the program's educational core. The selection of new project development scholars by the Program Executive Committee will be highly competitive and only those individuals with exceptional credentials or potential will be accepted by the program's Executive Committee. A novel strategy to recruit under-represented minorities to the program will be implemented. A career plan will be prepared for each scholar that will consider specific long and short- term research career goals and the competencies that will contribute to development as an independent investigator. The laboratories of the program's faculty in the Department of Pediatrics and in basic science departments will serve as sites for pediatric research faculty development. The CHRCDA program will utilize the Shared Core Laboratories at Mount Sinai School of Medicine such as state of the art methodology for cell and whole animal imaging, for production of transgenic and knockout mouse models, and for high- throughput gene screening and gene expression profiling. All CHRCDA scholars will participate in didactic sessions designed to enhance their mentored program. Regular research seminars and periodic laboratory workshops will also promote interactions among young investigators and program faculty. Overall, the program is enhanced by centralization of laboratory facilities and faculty, the existing interactions amongst research programs within the institution, the many core laboratory resources which are readily available to researchers, and the recruitment base of highly qualified applicants already attracted to the excellence of Mount Sinai's clinical departments and basic sciences.