Molecular & Developmental Biology in Pediatric Research

西奈山学校儿童健康研究职业发展奖(CHRCDA)计划 旨在提供为期2-3年的指导、密集的基础研究经验 为儿科医生在生物医学研究和独立职业生涯中多产和独立做准备 学院派儿科。这项提案的主题是“儿科学中的分子和发育生物学”， 与儿童时期最常见的疾病有独特的相关性。它包含了正常的发育 生物学以及胎儿和儿童对个体发育过程中的侮辱的适应。这个 该计划的多学科性质--借鉴世界上著名科学家的经验 儿科、人类遗传学、内科、分子、细胞和发育学系 生物学、免疫生物学、药理学和生物化学，以及生理学和生物物理学 从共同的兴趣、频繁的互动、过去对儿科科学家的培训和几个领域演变而来 教职员工正在进行的合作研究。该方案将提供严谨和灵活的基本 通过大学为儿科青年科学家提供研究经验！与中心教职员工互动，通过 由新项目开发奖提供的启动资金，并通过该计划的教育 核心。方案执行委员会将高度重视新项目开发学者的遴选工作 具有竞争力，只有那些具有特殊资历或潜力的个人才会被 该计划的执行委员会。一项招募代表人数不足的少数族裔参加该计划的新战略将 将会得到实施。将为每个学者准备一份职业计划，考虑具体的长期和短期- 学期研究的职业目标和能力将有助于作为一个独立的 调查员。该计划的教职员工在儿科和基础科学系的实验室 院系将作为儿科研究人员发展的场所。CHRCDA计划将利用 西奈山医学院的共享核心实验室，如最先进的方法学 细胞和整个动物成像，用于生产转基因和基因敲除小鼠模型，以及用于高度... 吞吐量基因筛选和基因表达谱分析。所有CHRCDA学者将参加说教 旨在加强他们的指导计划的会议。定期举办研究研讨会和定期实验室 研讨会还将促进年轻研究人员和项目教职员工之间的互动。总体而言， 该计划通过集中实验室设施和教师、现有的 机构内部的研究计划，许多核心实验室资源随时可以用来 研究人员和高素质申请者的招聘基础已经吸引到了 西奈山的临床科室和基础科学。

The Child Health Research Career Development Award (CHRCDA) Program at the Mount Sinai School of Medicine is designed to provide mentored, intensive basic research experience for a period of 2-3 years necessary to prepare pediatricians for productive and independent careers in biomedical research and academic pediatrics. The theme of this proposal, "Molecular and Developmental Biology in Pediatrics," has unique relevance to the most common disorders seen in childhood. It encompasses normal developmental biology as well as adaptation of the fetus and child to insults occurring during ontogenesis. The multidisciplinary nature of the program - drawing from the experience of established scientists inthe Department of Pediatrics, Human Genetics, Internal Medicine, Molecular, Cellular and Developmental Biology, Immunobiology, Pharmacology and Biological Chemistry, and Physiology and Biophysics - has evolved from common interests, frequent interactions, past training of pediatric scientists, and several areas of ongoing collaborative research of the faculty. The program will provide rigorous and flexible basic research experience for young pediatric scientists through collegia! interaction with Center faculty, through startup funding as provided by new project development awards, and through the program's educational core. The selection of new project development scholars by the Program Executive Committee will be highly competitive and only those individuals with exceptional credentials or potential will be accepted by the program's Executive Committee. A novel strategy to recruit under-represented minorities to the program will be implemented. A career plan will be prepared for each scholar that will consider specific long and short- term research career goals and the competencies that will contribute to development as an independent investigator. The laboratories of the program's faculty in the Department of Pediatrics and in basic science departments will serve as sites for pediatric research faculty development. The CHRCDA program will utilize the Shared Core Laboratories at Mount Sinai School of Medicine such as state of the art methodology for cell and whole animal imaging, for production of transgenic and knockout mouse models, and for high- throughput gene screening and gene expression profiling. All CHRCDA scholars will participate in didactic sessions designed to enhance their mentored program. Regular research seminars and periodic laboratory workshops will also promote interactions among young investigators and program faculty. Overall, the program is enhanced by centralization of laboratory facilities and faculty, the existing interactions amongst research programs within the institution, the many core laboratory resources which are readily available to researchers, and the recruitment base of highly qualified applicants already attracted to the excellence of Mount Sinai's clinical departments and basic sciences.