Molecular & Developmental Biology in Pediatric Research

分子

• 批准号: 7224278
• 负责人: FREDERICK J SUCHY
• 金额: $ 41.04万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7224278
• 关键词: Animals; Area; Arts; Award; Basic Science; Biochemistry; Biomedical Research; Biophysics; Cells; Child; Child health care; Childhood; Clinical; Credentialing; Development; Developmental Biology; Disease; Educational workshop; Faculty; Fetus; Funding; Gene Expression Profiling; Genes; Goals; Human Genetics; Image; Immunobiology; Individual; Institution; Internal Medicine; K-Series Research Career Programs; Knock-out; Laboratories; Mentors; Methodology; Molecular; NCI Scholars Program; Nature; Pediatric Research; Pediatrics; Pharmacology; Physiology; Production; Qualifying; Recruitment Activity; Research; Research Personnel; Resources; Scientist; Screening procedure; Site; Training; Transgenic Organisms; Underrepresented Minority; base; career; design; experience; interest; laboratory facility; medical schools; mouse model; multidisciplinary; novel strategies; pediatric department; pediatrician; programs

DESCRIPTION (provided by applicant): The Child Health Research Career Development Award (CHRCDA) Program at the Mount Sinai School of Medicine is designed to provide mentored, intensive basic research experience for a period of 2-3 years necessary to prepare pediatricians for productive and independent careers in biomedical research and academic pediatrics. The theme of this proposal, "Molecular and Developmental Biology in Pediatrics," has unique relevance to the most common disorders seen in childhood. It encompasses normal developmental biology as well as adaptation of the fetus and child to insults occurring during ontogenesis. The multidisciplinary nature of the program - drawing from the experience of established scientists in the Department of Pediatrics, Human Genetics, Internal Medicine, Molecular, Cellular and Developmental Biology, Immunobiology, Pharmacology and Biological Chemistry, and Physiology and Biophysics - has evolved from common interests, frequent interactions, past training of pediatric scientists, and several areas of ongoing collaborative research of the faculty. The program will provide rigorous and flexible basic research experience for young pediatric scientists through collegial interaction with Center faculty, through startup funding as provided by new project development awards, and through the program's educational core. The selection of new project development scholars by the Program Executive Committee will be highly competitive and only those individuals with exceptional credentials or potential will be accepted by the program's Executive Committee. A novel strategy to recruit under-represented minorities to the program will be implemented. A career plan will be prepared for each scholar that will consider specific long and short-term research career goals and the competencies that will contribute to development as an independent investigator. The laboratories of the program's faculty in the Department of Pediatrics and in basic science departments will serve as sites for pediatric research faculty development. The CHRCDA program will utilize the Shared Core Laboratories at Mount Sinai School of Medicine such as state of the art methodology for cell and whole animal imaging, for production of transgenic and knockout mouse models, and for high throughput gene screening and gene expression profiling. All CHRCDA scholars will participate in didactic sessions designed to enhance their mentored program. Regular research seminars and periodic laboratory workshops will also promote interactions among young investigators and program faculty. Overall, the program is enhanced by centralization of laboratory facilities and faculty, the existing interactions amongst research programs within the institution, the many core laboratory resources which are readily available to researchers, and the recruitment base of highly qualified applicants already attracted to the excellence of Mount Sinai's clinical departments and basic sciences.

描述（由申请人提供）：西奈山医学院的儿童健康研究职业发展奖（CHRCDA）计划旨在提供为期2-3年的指导，密集的基础研究经验，为儿科医生在生物医学研究和学术儿科学方面的生产和独立职业做好准备。本提案的主题是“儿科分子和发育生物学”，与儿童期最常见的疾病具有独特的相关性。它包括正常的发育生物学以及胎儿和儿童对个体发育过程中发生的损伤的适应。该计划的多学科性质-从儿科学，人类遗传学，内科学，分子，细胞和发育生物学，免疫生物学，药理学和生物化学，生理学和生物物理学系的成熟科学家的经验中汲取-已经从共同利益，频繁的互动，儿科科学家的过去培训以及教师正在进行的合作研究的几个领域发展而来。该计划将通过与中心教师的合议互动，通过新项目开发奖提供的启动资金，以及通过该计划的教育核心，为年轻的儿科科学家提供严格和灵活的基础研究经验。新的项目开发学者的选择由计划执行委员会将是高度竞争性的，只有那些具有特殊证书或潜力的个人将被该计划的执行委员会接受。将实施一项新的战略，招募代表性不足的少数民族参加该方案。将为每位学者制定职业计划，考虑具体的长期和短期研究职业目标以及作为独立调查员有助于发展的能力。该计划的儿科系和基础科学系的教师实验室将作为儿科研究教师发展的场所。CHRCDA计划将利用西奈山医学院的共享核心实验室，例如细胞和整个动物成像的最先进方法，用于生产转基因和敲除小鼠模型，以及高通量基因筛选和基因表达谱分析。所有CHRCDA学者将参加教学会议，旨在加强他们的辅导计划。定期的研究研讨会和定期的实验室研讨会也将促进年轻研究人员和项目教师之间的互动。总体而言，该计划通过实验室设施和教师的集中化，机构内研究计划之间的现有互动，研究人员可以随时获得的许多核心实验室资源以及已经吸引到西奈山临床部门和基础科学卓越的高素质申请人的招聘基础来增强。