SPECTROSCOPY CONSOLE AND GRADIENTS FOR 7T NMR SYSTEM

我们正在申请购买Bruker Avarice DBX核磁共振的资金 光谱/成像控制台和带有射频线圈的屏蔽梯度设置 放置在位于耶鲁磁铁的7.OT 20厘米口径磁铁上 共鸣中心。7.OT系统一直走在 磁共振波谱和磁共振成像方法的发展和应用 新陈代谢的调节以及新陈代谢如何在病理学上改变。 在项目部分中描述的研究正在处理 基础生物化学/生理学和临床前沿问题 科学包括大脑功能活动的能量需求， 抗癫痫药物与GABA代谢的相互作用 新生儿大脑皮质对低氧的功能、代谢适应 肌肉和肝脏碳水化合物代谢的改变在 糖尿病的发病机制以及代谢在其中的调节作用 神经递质谷氨酸和GABA池。对以下方面的见解 从这些研究中获得的代谢调节指导我们 相似方法在人体病理学研究中的应用 患者使用我们的2.1T全身系统，该系统目前配备了 Avance游戏机。目前，我们进一步提高MR的能力 方法受到过时的控制台和梯度设置的阻碍。这个 所要求的设备将允许我们继续开发和应用状态 将ART核磁共振方法学应用于本文件中描述的研究问题 求婚。在许多实验中，新设备将导致2-4倍的 提高了敏感度和空间分辨率。这个 由请求的设备提供的MRS和MRI的改进将允许 耶鲁大学研究人员将走在基础和临床研究的前沿 新陈代谢和生理学。

We are requesting funds to purchase a Bruker Avarice DBX NMR spectroscopy/imaging console and shielded gradient set with rf coil to be placed on a 7.OT 20 cm bore magnet located in the Yale Magnetic Resonance Center. The 7.OT system has been in the forefront in the development and application of MRS and MRI methods to understand the regulation of metabolism and how metabolism is altered in pathology. The studies which are described in the project section are addressing cutting edge issues in basic biochemistry/physiology and clinical science including the energy requirements of brain functional activity, the interaction between anti epileptic compounds and GABA metabolism and function, metabolic adaptations of the neonatal cortex to hypoxia, the role of altered muscle and liver carbohydrate metabolism in the pathogenesis of diabetes, and the role of metabolism in the regulation of neurotransmitter glutamate and GABA pools. The insights into metabolic regulation obtained from these studies has guided us in the application of similar methods in the study of pathology in human patients on our 2.1T whole body system which is presently equipped with an Avance console. Presently our ability to further improve the MR methodology is hampered by an obsolete console and gradient set. The requested equipment will allow us to continue to develop and apply state of the art NMR methodology to the research problems described in this proposal. In many experiments the new equipment will lead to a 2-4 fold improvement in sensitivity and spatial resolution improvement. The improvements in MRS and MRI provided by requested equipment will allow Yale researchers to stay in the forefront of basic and clinical studies of metabolism and physiology.