CORE--MRS/MRI Core

CORE--MRS/MRI 核心

• 批准号: 6844970
• 负责人: Douglas Lyle Rothman
• 金额: $ 20.81万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6844970
• 关键词: bioimaging /biomedical imaging; biomedical facility; carbohydrate metabolism; insulin sensitivity /resistance; lipid metabolism; mitochondria; noninsulin dependent diabetes mellitus; nuclear magnetic resonance spectroscopy

Since its establishment in 1985 the Yale Magnetic Resonance Research Center (MRRC) has been a leader in the development and application of MRS technology and 13C isotopic labeling strategies for studying carbohydrate and lipid metabolism in insulin resistance. Much of the initial support for the development of the MRRC core research program came from NIDDK. Recently the MRRC has moved to a new 30,000 square foot building and has added a new 4.0T human MRS/MRI system dedicated to studying metabolism. The primary aim of the MRS/MRI Core will be to provide comprehensive MRS and MRI support on this system for the projects clinical core. Core services provided are i) MRS and MRI methodology at 4.0T for studying brain liver and muscle mitochondrial function ii) metabolic modeling to obtain metabolic fluxes from MRS measurements, iii) MRS/MR system operation and data analysis, and iv) regular quality control measures to ensure the reliability of the MRS and MRI. In addition to being critical for the success of the program project, the MRS and MRI methodology and quality control procedures implemented by the core will benefit all NIDDK investigators (both within and outside Yale) using the facility.

自1985年成立以来，耶鲁磁共振研究中心（MRRC）一直是MRS技术和13 C同位素标记策略的开发和应用的领导者，用于研究胰岛素抵抗中的碳水化合物和脂质代谢。对MRRC核心研究计划的开发的大部分最初支持来自NIDDK。最近，MRRC搬到了一个新的30，000平方英尺的建筑，并增加了一个新的4.0T人类MRS/MRI系统，致力于研究代谢。MRS/MRI核心的主要目的是在该系统上为项目临床核心提供全面的MRS和MRI支持。提供的核心服务包括i）4.0T的MRS和MRI方法学，用于研究大脑、肝脏和肌肉线粒体功能ii）代谢建模，以获得MRS的代谢通量 测量，iii）MRS/MR系统操作和数据分析，以及iv）定期质量控制措施，以确保MRS和MRI的可靠性。除了对项目的成功至关重要外，MRS和MRI方法以及核心实施的质量控制程序将使使用该设施的所有NIDDK研究人员（耶鲁内外）受益。