CORE--MRS/MRI Core

自1985年成立以来，耶鲁大学磁共振研究中心(MRRC)在研究胰岛素抵抗中碳水化合物和脂肪代谢的MRS技术和13C同位素标记策略的开发和应用方面一直处于领先地位。对MRRC核心研究计划发展的大部分初始支持来自NIDDK。最近，MRRC搬进了一座新的30,000平方英尺的建筑，并增加了一台新的4.0T人体MRS/MRI系统，专门用于研究新陈代谢。MRS/MRI核心的主要目标将是在该系统上为项目临床核心提供全面的MRS和MRI支持。提供的核心服务是I)用于研究脑、肝脏和肌肉线粒体功能的4.0T的MRS和MRI方法II)代谢建模以从MRS获得代谢流 三)MRS/MR系统操作和数据分析；以及四)定期质量控制措施，以确保MRS和MRI的可靠性。除了对计划项目的成功至关重要，CORE实施的MRS和MRI方法以及质量控制程序将使所有使用该设施的NIDDK研究人员(包括耶鲁大学内外)受益。

Since its establishment in 1985 the Yale Magnetic Resonance Research Center (MRRC) has been a leader in the development and application of MRS technology and 13C isotopic labeling strategies for studying carbohydrate and lipid metabolism in insulin resistance. Much of the initial support for the development of the MRRC core research program came from NIDDK. Recently the MRRC has moved to a new 30,000 square foot building and has added a new 4.0T human MRS/MRI system dedicated to studying metabolism. The primary aim of the MRS/MRI Core will be to provide comprehensive MRS and MRI support on this system for the projects clinical core. Core services provided are i) MRS and MRI methodology at 4.0T for studying brain liver and muscle mitochondrial function ii) metabolic modeling to obtain metabolic fluxes from MRS measurements, iii) MRS/MR system operation and data analysis, and iv) regular quality control measures to ensure the reliability of the MRS and MRI. In addition to being critical for the success of the program project, the MRS and MRI methodology and quality control procedures implemented by the core will benefit all NIDDK investigators (both within and outside Yale) using the facility.