LINKAGE ANALYSIS OF PROSTATE CANCER

这项研究是一项连锁分析，对有 人类前列腺癌。1996年发表在《科学》杂志上的一篇论文 这一组表明了前列腺癌基因座连锁的可能性 癌症发生在1号染色体的一个区域。这已经被追踪到了 通过对额外家系与标记的密集连锁分析 在这一地区和其他地区，显示出一些温和的证据 在最初的基因组扫描中存在连锁。已经获得了家庭 和来自美国、芬兰几个地区的基因分型 还有瑞典。此外，还在努力发展更多的家庭 此项目的资源。X染色体上的第二个基因座 在本财年通过关联分析绘制了结果图 发表于《自然遗传学》，20：175-179(1998)。这些 调查人员还加入了一项全国性的前列腺癌联系 该联盟试图更快地定位前列腺癌部位。这 识别和克隆前列腺癌基因的项目正在进行中。

This study is a linkage analysis of families with human prostate cancer. A paper published in Science in 1996 by this group indicates the possibility of linkage of a locus for prostate cancer to a region of chromosome 1. This has been followed up this year by intensive linkage analyses of additional families to markers in this region and in other regions that showed some mild evidence of linkage in the initial genome scan. Families have been obtained and genotyped from several regions of the United States, Finland and Sweden. Efforts are also underway to develop additional family resources for this project. A second locus on the X chromosome has been mapped by linkage analysis in this fiscal year with results published in Nature Genetics, 20:175-179 (1998). These investigators have also joined a national Prostate Cancer Linkage Consortium to try to localize prostate cancerloci more rapidly. This project to identify and clone genes for prostate cancer is ongoing.