LINKAGE ANALYSIS OF PROSTATE CANCER

前列腺癌的连锁分析

• 批准号: 6109033
• 负责人: Joan Ellen Bailey-Wilson
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6109033
• 关键词: clinical research; family genetics; gene expression; genetic markers; genotype; human subject; linkage mapping; molecular cloning; neoplasm /cancer genetics; prostate neoplasms

This study is a linkage analysis of families with human prostate cancer. A paper published in Science in 1996 by this group indicates the possibility of linkage of a locus for prostate cancer to a region of chromosome 1. This has been followed up this year by intensive linkage analyses of additional families to markers in this region and in other regions that showed some mild evidence of linkage in the initial genome scan. Families have been obtained and genotyped from several regions of the United States, Finland and Sweden. Efforts are also underway to develop additional family resources for this project. A second locus on the X chromosome has been mapped by linkage analysis in this fiscal year with results published in Nature Genetics, 20:175-179 (1998). These investigators have also joined a national Prostate Cancer Linkage Consortium to try to localize prostate cancerloci more rapidly. This project to identify and clone genes for prostate cancer is ongoing.

这项研究是一个家庭的连锁分析， 人类前列腺癌。1996年发表在《科学》杂志上的一篇论文， 这一组表明前列腺的一个位点连锁的可能性， 癌症转移到1号染色体的区域。这一点已被跟进， 通过对额外家庭与标记的密集连锁分析，今年 在这个地区和其他地区， 在最初的基因组扫描中发现了关联。家庭已经获得了 并对来自美国、芬兰、 和瑞典还在努力发展更多的家庭 这个项目的资源。X染色体上的第二个位点 在本财政年度通过关联分析绘制了 发表于Nature Genetics，20：175-179（1998）。这些 研究人员还加入了一个全国性的前列腺癌联系 联盟试图更快地定位前列腺癌的位置。这 鉴定和克隆前列腺癌基因的项目正在进行中。