Genetics of Inflammatory Bowel Disease

炎症性肠病的遗传学

• 批准号: 6433684
• 负责人: Joan Ellen Bailey-Wilson
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6433684
• 关键词: family genetics; genetic markers; genotype; human data; inflammatory bowel diseases; linkage mapping; molecular biology information system

This project to study the genetics of Inflammatory Bowel Disease(IBD) was initiated in this fiscal year in collaboration withDrs. Steven Brant and Theodore Bayliss of Johns HopkinsUniversity School of Medicine and with the International IBDConsortium. An international consortium of investigators who havepreviously published genome wide linkage screens for IBD wasformed and all members agreed to genotype the same markers in twocandidate regions on at least 50 highly families with bothparents and two or more affected children available forgenotyping. These data were then deposited into a common databaseat the University of Canberra, anonymized and then distributed tothe participating groups. Each group performed its own analysesof these data and presented them at a workshop in Australia inSeptember. Additional genotyping is ongoing and a manuscript isin preparation. Dr. Bailey-Wilson has been named head of theAnalysis committee for this consortium and will continue tointeract with Drs. Brant, Bayliss and the IBD Consortium onfuture analyses of the genetics of IBD. - Inflammatory bowel disease, Crohn's disease, ulcerative colitis, genetics, IBD Consortium - Human Subjects

这个研究炎症性肠病（IBD）遗传学的项目是在本财政年度与dr。约翰霍普金斯大学医学院的Steven Brant和Theodore Bayliss以及国际ibd联盟说。此前发表过IBD全基因组连锁筛选的国际研究人员组成了一个国际联盟，所有成员都同意在至少50个父母双方和两个或两个以上患病儿童可进行基因分型的高度家庭的两个候选区域对相同的标记进行基因分型。这些数据随后被存入堪培拉大学的一个公共数据库，匿名后分发给参与小组。每个小组都对这些数据进行了自己的分析，并于9月在澳大利亚的一个研讨会上发表了这些数据。额外的基因分型正在进行中，手稿正在准备中。Bailey-Wilson博士已被任命为该联盟分析委员会的负责人，并将继续与dr。Brant， Bayliss和IBD联盟对IBD遗传学的未来分析。-炎症性肠病，克罗恩病，溃疡性结肠炎，遗传学，IBD联盟-人类受试者