Genetics of Inflammatory Bowel Disease

这个研究炎症性肠病(IBD)遗传学的项目是在本财年与DR合作启动的。约翰霍普金斯大学医学院和国际IBD联盟的史蒂文·布兰特和西奥多·贝利斯。一个先前发表过IBD全基因组连锁筛查的国际研究联盟已经成立，所有成员同意在至少50个父母双方以及两个或更多受影响的儿童可进行基因分型的高风险家庭中，在两个条件区域内对相同的标记进行基因分型。这些数据随后被存储到堪培拉大学的一个公共数据库中，进行匿名处理，然后分发给参与小组。每个小组都对这些数据进行了自己的分析，并于9月份在澳大利亚的一个研讨会上展示了这些数据。更多的基因分型正在进行中，手稿正在准备中。贝利-威尔逊博士已被任命为该联盟分析委员会的负责人，并将继续与Brant博士、Bayliss博士和IBD联盟就未来IBD的遗传学分析进行互动。-炎症性肠病、克罗恩病、溃疡性结肠炎、遗传学、IBD联盟-人类受试者

This project to study the genetics of Inflammatory Bowel Disease(IBD) was initiated in this fiscal year in collaboration withDrs. Steven Brant and Theodore Bayliss of Johns HopkinsUniversity School of Medicine and with the International IBDConsortium. An international consortium of investigators who havepreviously published genome wide linkage screens for IBD wasformed and all members agreed to genotype the same markers in twocandidate regions on at least 50 highly families with bothparents and two or more affected children available forgenotyping. These data were then deposited into a common databaseat the University of Canberra, anonymized and then distributed tothe participating groups. Each group performed its own analysesof these data and presented them at a workshop in Australia inSeptember. Additional genotyping is ongoing and a manuscript isin preparation. Dr. Bailey-Wilson has been named head of theAnalysis committee for this consortium and will continue tointeract with Drs. Brant, Bayliss and the IBD Consortium onfuture analyses of the genetics of IBD. - Inflammatory bowel disease, Crohn's disease, ulcerative colitis, genetics, IBD Consortium - Human Subjects