GENETIC ANALYSIS OF HEREDITARY NONSYNDROMIC ORAL CLEFTS

这个项目是在上一财年开始的。它 涉及收集临床信息和血液样本，以 叙利亚高度近亲交配家庭的基因分型 许多成员都患有唇腭裂。与中国的合作 叙利亚当地调查人员和穆沙拉夫对叙利亚长达一个月的访问。 Wyszynski收集了20多个大型家系 适用于纯合子技术的连锁分析 映射。数据收集工作正在进行中。10厘米纯合子 测绘基因组扫描已完成，但没有阳性结果。 与JHUSPH的特里·比蒂博士的合作已经启动 以增加力量。我们来自叙利亚的样本将在 CIDR和比蒂？S博士从其他几个地点和 协作性链接分析将在 即将到来的财年。

This project was begun in the previous fiscal year. It involves collection of clinical information and blood samples for genotyping in highly inbred families in Syria from families with many members affected with cleft lip and palate. Cooperation with Syrian local investigators and a month long visit to Syria by Dr. Wyszynski have resulted in collection of over 20 large pedigrees suitable for linkage analysis by the technique of homozygosity mapping. Data collection is ongoing. A 10 cM homozygosity mapping genome scan has been completed with no positive results. A collaboration with Dr. Terri Beaty of JHUSPH has been initiated to increase power. Our samples from Syria will be genotyped at CIDR along with Dr. Beaty?s samples from several other sites and collaborative linkage analyses will be performed during the upcoming fiscal year.