GENETICS OF HUMAN LUNG CANCER

在本财年，这个最初在贝利-威尔逊博士担任路易斯安那州立大学医学中心教授时开始的项目一直在继续。本财政年度完成的工作包括筛查病例和收集家庭数据、收集血液和组织样本。这项研究的目的是确定一个或多个与肺癌易感性有关的基因。其具体目的是1)收集肺癌患者及其家人的肺癌家族史和环境危险因素数据，并从似乎为连锁分析提供信息的家系子集收集血液和组织样本；2)对基因组范围内的一组标记基因座的生物样本进行基因分型；3)进行全基因组连锁分析，试图定位肺癌易感基因座。在本财政年度，从新的和以前研究的家庭收集了家族史和生物样本。贝利-威尔逊博士在建立肺癌遗传流行病学协会(GELCC)方面发挥了重要作用，目的是从一大群合作研究人员那里获得更多的家庭数据。到目前为止，已经开始对收集到的三个信息量最大的家系进行基因分型。数据收集工作正在进行中，预计还将持续数年。遗传病研究中心(CIDR)今年已批准对GELCC家系进行全基因组扫描，第一组家系将于2000年1月送交CIDR。这组家庭中约有五分之一将来自路易斯安那州的数据收集工作。作为GELCC分析委员会的负责人，贝利-威尔逊博士将负责这些数据的分析。-连锁、肺癌、遗传学、吸烟、家系、遗传性

During this fiscal year, this project, originally begun when Dr. Bailey-Wilson was a Professor at Louisiana State University Medical Center, has been continued. Work accomplished in thisfiscal year has included screening of cases and collection of family data collection and blood and tissue samples. The purpose of this study is to identify a gene or genes that contribute to lung cancer susceptibility. The specific aims are to 1) collect family history and environmental risk factor data about lung cancer from lung cancer patients and their families and to also collect blood and tissue samples from a subset of the families that appear informative for linkage analysis; 2) genotype the biological samples for a genome wide set of marker loci; 3) perform a genome-wide linkage analysis to attempt to localize a lung cancer susceptibility locus (loci). In this fiscal year, family history and biologic samples have been collected from both new and previously studied families. Dr. Bailey-Wilson has been instrumental in founding the Genetic Epidemiology of Lung Cancer Consortium (GELCC) for the purpose of obtaining additional family data from a large group of collaborative investigators. Genotyping has been started on three of the most informative pedigrees collected thus far. Data collection is ongoing and expected to continue for several more years. Approval for a genome-wide scan of the GELCC pedigrees by the Center for Inherited Disease Research (CIDR) has been obtained this year, and the first set of families will be sent to CIDR in January, 2000. Approximately one- fifth of this set of families will be from the Louisiana data collection effort. As head of the GELCC Analysis committee, Dr. Bailey- Wilson will be in charge of the analyses of these data. - linkage, lung cancer, genetics, smoking, pedigrees, hereditary