GENETICS OF HUMAN LUNG CANCER

人类肺癌的遗传学

• 批准号: 6290299
• 负责人: Joan Ellen Bailey-Wilson
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6290299
• 关键词: blood chemistry; cancer risk; clinical research; data collection methodology /evaluation; environmental contamination; family genetics; genetic mapping; genetic markers; genetic registry /resource /referral center; genotype; human data; human genetic material tag; linkage mapping; lung neoplasms; neoplasm /cancer genetics

During this fiscal year, this project, originally begun when Dr. Bailey-Wilson was a Professor at Louisiana State University Medical Center, has been continued. Work accomplished in thisfiscal year has included screening of cases and collection of family data collection and blood and tissue samples. The purpose of this study is to identify a gene or genes that contribute to lung cancer susceptibility. The specific aims are to 1) collect family history and environmental risk factor data about lung cancer from lung cancer patients and their families and to also collect blood and tissue samples from a subset of the families that appear informative for linkage analysis; 2) genotype the biological samples for a genome wide set of marker loci; 3) perform a genome-wide linkage analysis to attempt to localize a lung cancer susceptibility locus (loci). In this fiscal year, family history and biologic samples have been collected from both new and previously studied families. Dr. Bailey-Wilson has been instrumental in founding the Genetic Epidemiology of Lung Cancer Consortium (GELCC) for the purpose of obtaining additional family data from a large group of collaborative investigators. Genotyping has been started on three of the most informative pedigrees collected thus far. Data collection is ongoing and expected to continue for several more years. Approval for a genome-wide scan of the GELCC pedigrees by the Center for Inherited Disease Research (CIDR) has been obtained this year, and the first set of families will be sent to CIDR in January, 2000. Approximately one- fifth of this set of families will be from the Louisiana data collection effort. As head of the GELCC Analysis committee, Dr. Bailey- Wilson will be in charge of the analyses of these data. - linkage, lung cancer, genetics, smoking, pedigrees, hereditary

在本财政年度，贝利-威尔逊博士担任路易斯安那州立大学医学中心教授时开始的这个项目继续进行。本财政年度完成的工作包括病例筛查和家庭数据收集以及血液和组织样本收集。这项研究的目的是确定一个或多个基因有助于肺癌易感性。具体目标是：1)从肺癌患者及其家庭中收集有关肺癌的家族史和环境风险因素数据，并从一部分家庭中收集血液和组织样本，为关联分析提供信息；2)对生物样品进行全基因组标记位点的基因分型；3)进行全基因组连锁分析，试图定位肺癌易感位点。在本财政年度，从新的和以前研究过的家庭中收集了家族史和生物样本。Bailey-Wilson博士在建立肺癌遗传流行病学联盟（GELCC）方面发挥了重要作用，该联盟旨在从一大批合作研究人员那里获得额外的家庭数据。目前已开始对收集到的三个信息最丰富的家系进行基因分型。数据收集工作正在进行中，预计还将持续数年。遗传疾病研究中心（CIDR）今年已批准对GELCC家系进行全基因组扫描，第一批家庭将于2000年1月送到CIDR。大约五分之一的这组家庭将来自路易斯安那州的数据收集工作。作为GELCC分析委员会的负责人，贝利-威尔逊博士将负责这些数据的分析。-连锁，肺癌，遗传，吸烟，血统，遗传