Genetics of ADHD

多动症的遗传学

• 批准号: 6681677
• 负责人: Joan Ellen Bailey-Wilson
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6681677
• 关键词: attention deficit disorder; behavioral genetics; clinical research; computer simulation; cooperative study; experimental designs; family genetics; gene expression; genetic disorder; genetic screening; human genetic material tag; human subject; linkage mapping; phenotype; statistics /biometry

Dr. Bailey-Wilson is a member of a collaborative study of Attention Deficit Hyperactivity Disorder, collaborating with Drs. Max Muenke and Kate Berg of NHGRI and Dr. Mauricio Arcos-Burgos of Columbia. Dr. Bailey-Wilson's role is to help with study design and to serve as statistical geneticist on the project. In the past, we have performed power studies of many large pedigrees from Columbia, showing that there will be adequate power in a linkage study to detect genes of moderate to large effect, even in the presence of heterogeneity. Dr. Bailey-Wilson also advises the other collaborators about the types of pedigree structures that are particularly informative for linkage studies. A paper detailing the study design and the simulation has been submitted. In this fiscal year, linkage and association studies have been performed on the first set of large pedigrees from Columbia for markers in several candidate loci. A manuscript reporting these results is in preparation.

贝利-威尔逊博士是注意力缺陷多动障碍合作研究的成员，与NHGRI的马克斯-穆恩克博士和凯特-贝格博士以及哥伦比亚的毛里西奥-阿科斯-布尔戈斯博士合作。Bailey-Wilson博士的角色是帮助研究设计，并担任该项目的统计遗传学家。在过去，我们对来自哥伦比亚的许多大家系进行了功效研究，表明即使存在异质性，连锁研究也有足够的功效来检测中到大效应的基因。贝利-威尔逊博士还建议其他合作者关于系谱结构的类型，特别是连锁研究的信息。已经提交了一份详细介绍研究设计和模拟的文件。在本财政年度，连锁和关联研究已经进行了第一套大型家系从哥伦比亚的标记在几个候选位点。报告这些结果的手稿正在编写中。