Genetics of ADHD

贝利-威尔逊博士是一项关于注意力缺陷多动障碍的合作研究的成员，该研究与NHGRI的Max Muenke博士和Kate Berg博士以及哥伦比亚大学的Mauricio Arcos-Burgos博士合作。贝利-威尔逊博士的角色是帮助研究设计，并在该项目中担任统计遗传学家。过去，我们对哥伦比亚大学的许多大型家系进行了POWER研究，结果表明，即使在存在异质性的情况下，连锁研究也有足够的能力检测中到大效应的基因。贝利-威尔逊博士还向其他合作者提供建议，说明对连锁研究特别有用的谱系结构类型。已提交了详细说明研究设计和模拟的论文。在本财政年度，对来自哥伦比亚大学的第一组大型家系进行了连锁和关联研究，以寻找几个候选基因座的标记。一份报告这些结果的手稿正在准备中。

Dr. Bailey-Wilson is a member of a collaborative study of Attention Deficit Hyperactivity Disorder, collaborating with Drs. Max Muenke and Kate Berg of NHGRI and Dr. Mauricio Arcos-Burgos of Columbia. Dr. Bailey-Wilson's role is to help with study design and to serve as statistical geneticist on the project. In the past, we have performed power studies of many large pedigrees from Columbia, showing that there will be adequate power in a linkage study to detect genes of moderate to large effect, even in the presence of heterogeneity. Dr. Bailey-Wilson also advises the other collaborators about the types of pedigree structures that are particularly informative for linkage studies. A paper detailing the study design and the simulation has been submitted. In this fiscal year, linkage and association studies have been performed on the first set of large pedigrees from Columbia for markers in several candidate loci. A manuscript reporting these results is in preparation.