CORONARY ATHEROSCLEROSIS IN FEMALE MONKEYS

雌性猴子的冠状动脉粥样硬化

• 批准号: 2717275
• 负责人: THOMAS B CLARKSON
• 金额: $ 184.27万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2717275
• 关键词: alternative medicine; atherosclerosis; cardiovascular disorder prevention; coronary disorder; estrogens; female; hormone therapy; postmenopause; soybeans

There is a well-established association between postmenopausal estrogen replacement and decreased rates of coronary heart disease among women. Estimates of reduction range from about 50% to as much as 70%. Poor compliance with estrogen replacement therapy by postmenopausal women has prevented a major impact on the public health since only about 8% of women continue the treatment over the years in which prevention of coronary heart disease and osteoporosis are important. We have sought to identify an alternative regimen that would be more acceptable to women and still provide protection against coronary heart disease and osteoporosis. Specifically, we propose to compare the therapeutic/prophylactic benefits of conjugated equine estrogens and soybean estrogens in the prevention of postmenopausal coronary artery atherosclerosis/dysfunction, osteoporosis, and mammary gland and endometrial hyperplasia/dysplasia (monkey studies) and compare their effects on progression of carotid artery atherosclerosis, changes in bone density, and quality of life/compliance issues (human studies). The rationale is based upon the putative protective effect of these compounds against the development of breast cancer and osteoporosis, the likely lack of a harmful effect on the uterus, and an experimental basis for assuming probable favorable effects on coronary artery atherosclerosis. The Program Project takes advantage of the capabilities of our institution in conducting randomized trials in both human and nonhuman primates and the capabilities for exploring mechanisms of mammalian and plant estrogen effects on atherogenesis and vascular function.

绝经后的雌激素与 更新换代和降低妇女的冠心病发病率。 估计的降幅从大约50%到多达70%不等。穷 绝经后妇女对雌激素替代疗法的依从性 防止了对公共健康的重大影响，因为只有大约8%的女性 在预防冠心病的多年来继续治疗 心脏病和骨质疏松症很重要。 我们已经寻求找到一种替代方案，它将比 为女性所接受，但仍可预防冠心病 疾病和骨质疏松症。具体地说，我们建议将 马结合雌激素的治疗/预防益处和 大豆雌激素对绝经后冠状动脉病变的预防作用 动脉粥样硬化/功能障碍，骨质疏松症，乳腺和 子宫内膜增生症/异型增生(猴子研究) 对颈动脉粥样硬化进展、骨质改变的影响 密度和生活质量/遵从性问题(人体研究)。这个 基本原理是基于这些化合物假定的保护作用。 针对乳腺癌和骨质疏松症的发展，可能缺乏 对子宫的有害影响，以及假设的实验基础 可能对冠状动脉粥样硬化有有利作用。 该计划项目利用了我们机构的能力 在人类和非人类灵长类动物中进行随机试验 探索哺乳动物和植物雌激素作用机制的能力 对动脉粥样硬化形成和血管功能的影响。