DIETARY SOY SUPPLEMENTATION IN MENOPAUSE

更年期膳食大豆补充剂

• 批准号: 6110062
• 负责人: THOMAS B CLARKSON
• 金额: $ 23.03万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6110062
• 关键词: Macaca fascicularis; alternative medicine; atherosclerosis; blood lipoprotein; cardiovascular disorder prevention; chemoprevention; coronary disorder; dietary proteins; dietary supplements; disease /disorder model; disease /disorder proneness /risk; estrogens; female; genistein; hormone therapy; nonhuman therapy evaluation; osteoporosis; pathologic process; postmenopause; soybeans

The objective of the research proposed in this Project is to evaluate a potential nutritional alternative to CEE replacement therapy that would provide a beneficial effect on postmenopausal CHD and osteoporosis but would be free of adverse effects on the breast and uterus. We have chosen to focus on the phytoestrogens of soybeans (genistein and daidzein) because: Asian women who consume diets relatively high in the soybean estrogens (SBE) have a low occurrence of postmenopausal CHD. An extensive literature exists suggesting that genistein has important inhibitory effects at several levels of atherogenesis. Data obtained in our laboratory indicate favorable effects of SBE on plasma lipid and lipoprotein profiles. The literature to date suggests a protective effect of SBE against the development of breast cancer and a lack of effect on the endometrium. Epidemiologic and experimental evidence suggests that phytoestrogens prevent bone loss postmenopausally. Nutritional supplements rich in these phytoestrogens are available. One hundred eighty-nine surgically postmenopausal monkeys were randomized into three groups (all fed a moderately atherogenic diet): one group fed a soy isolate with only trace amounts of genistein and daidzein as the source of dietary protein (Group 1); one fed the same diet with conjugated equine estrogens added at a dose equivalent for a woman of 0.625 mg/day (Group 2); and one fed a soy isolate with the naturally occurring amounts of genistein and daidzein (1.7 mg/g) (Group 3). The aims of the research are to quantify the relative effectiveness of CEE and SBE in inhibiting the progression of postmenopausal coronary artery atherosclerosis, the effects of treatment with CEE and SBE on mammary gland and endometrial hyperplasia, the relative effectiveness of CEE and SBE in inhibiting postmenopausal bone loss, and whether CEE and SBE treatment results in a disassociation of the relationship between cardiac hyperactivity and exacerbated coronary artery atherosclerosis we have observed for estradiol.

本项目建议的研究目标是评估 CEE替代疗法的潜在营养替代品， 对绝经后CHD和骨质疏松症具有有益作用， 不会对乳房和子宫产生不良影响。 我们选择 关注大豆中的植物雌激素（染料木黄酮和大豆苷元） 因为： 饮食中大豆雌激素含量相对较高的亚洲女性 (SBE)绝经后冠心病的发生率较低。 大量文献表明染料木黄酮具有重要的 在几个水平的动脉粥样硬化形成的抑制作用。 我们实验室获得的数据表明，SBE对 血浆脂质和脂蛋白谱。 迄今为止的文献表明，SBE的保护作用， 乳腺癌的发展和对子宫内膜缺乏影响。 流行病学和实验证据表明， 预防绝经后骨质流失。 富含这些植物雌激素的营养补充剂是可用的。 189只手术绝经后的猴子被随机分组， 分为三组（均喂食中度致动脉粥样硬化饮食）：一组喂食 大豆分离物仅含有痕量的染料木黄酮和大豆苷元， 膳食蛋白质来源（第1组）;一组喂食相同的饮食， 以0.625 mg/天的女性剂量当量添加马雌激素 （组2）;和一个喂养大豆分离物与自然发生的量 染料木黄酮和大豆苷元（1.7mg/g）（组3）。 研究的目的是量化大学英语教育的相对有效性 和SBE抑制绝经后冠状动脉病变进展 CEE和SBE治疗对乳腺动脉粥样硬化的影响 腺体和子宫内膜增生，CEE的相对有效性， SBE抑制绝经后骨质流失，以及CEE和SBE是否 治疗的结果是分离的关系，心脏 多动和恶化的冠状动脉粥样硬化， 观察雌二醇。