DIETARY SOY SUPPLEMENTATION IN MENOPAUSE

本项目建议的研究目的是评估一个 CEE替代疗法的潜在营养替代品将 对绝经后冠心病和骨质疏松症有有益的作用，但 将不会对乳房和子宫产生不良影响。我们已经选择了 关注大豆中的植物雌激素(染料木素和大豆苷元) 因为： 饮食中大豆雌激素含量相对较高的亚洲女性 (SBE)绝经后冠心病发生率较低。 大量文献表明，染料木素具有重要的 在动脉粥样硬化形成的多个水平上的抑制作用。 我们实验室获得的数据表明，SBE对 血浆脂质和脂蛋白图谱。 到目前为止的文献表明，SBE对 乳腺癌的发生和对子宫内膜的影响不足。 流行病学和实验证据表明，植物雌激素 防止绝经后骨质流失。 富含这些植物雌激素的营养补充剂是可用的。 189只接受手术治疗的绝经后猴子被随机分配 分成三组(均喂以中度致动脉粥样硬化的饮食)：一组喂食 一种只含有微量染料木素和大豆苷元的大豆分离株 膳食蛋白质来源(第1组)；饲喂相同食物的人 马雌激素的添加剂量相当于女性每天0.625毫克 (第2组)；另一组喂食含有自然产生的量的大豆分离物 染料木素和大豆苷元(1.7 mg/g)(第3组)。 研究的目的是量化高考的相对有效性。 和SBE对绝经后冠状动脉进展的抑制作用 动脉粥样硬化，CEE和SBE对乳腺的影响 CEE与子宫内膜增生症的相对疗效 SBE抑制绝经后骨丢失及CEE和SBE 治疗导致心脏和心脏之间关系的分离 过度活跃和加剧的冠状动脉粥样硬化 观察雌二醇值。

The objective of the research proposed in this Project is to evaluate a potential nutritional alternative to CEE replacement therapy that would provide a beneficial effect on postmenopausal CHD and osteoporosis but would be free of adverse effects on the breast and uterus. We have chosen to focus on the phytoestrogens of soybeans (genistein and daidzein) because: Asian women who consume diets relatively high in the soybean estrogens (SBE) have a low occurrence of postmenopausal CHD. An extensive literature exists suggesting that genistein has important inhibitory effects at several levels of atherogenesis. Data obtained in our laboratory indicate favorable effects of SBE on plasma lipid and lipoprotein profiles. The literature to date suggests a protective effect of SBE against the development of breast cancer and a lack of effect on the endometrium. Epidemiologic and experimental evidence suggests that phytoestrogens prevent bone loss postmenopausally. Nutritional supplements rich in these phytoestrogens are available. One hundred eighty-nine surgically postmenopausal monkeys were randomized into three groups (all fed a moderately atherogenic diet): one group fed a soy isolate with only trace amounts of genistein and daidzein as the source of dietary protein (Group 1); one fed the same diet with conjugated equine estrogens added at a dose equivalent for a woman of 0.625 mg/day (Group 2); and one fed a soy isolate with the naturally occurring amounts of genistein and daidzein (1.7 mg/g) (Group 3). The aims of the research are to quantify the relative effectiveness of CEE and SBE in inhibiting the progression of postmenopausal coronary artery atherosclerosis, the effects of treatment with CEE and SBE on mammary gland and endometrial hyperplasia, the relative effectiveness of CEE and SBE in inhibiting postmenopausal bone loss, and whether CEE and SBE treatment results in a disassociation of the relationship between cardiac hyperactivity and exacerbated coronary artery atherosclerosis we have observed for estradiol.